Robert M O'Brien

US Patent:

8552242, Oct 8, 2013

Filed:

Feb 8, 2011

Appl. No.:

13/023400

Inventors:

Amir H. Hoveyda - Lincoln MA, US
Simon J. Meek - Newtonville MA, US
Robert V. O'Brien - Brighton MA, US
Josep Llaveria Cros - Tarragona, ES
Richard R. Schrock - Winchester MA, US

Assignee:

Massachusetts Institute of Technology - Cambridge MA
Trustees of Boston College - Chestnut Hill MA

International Classification:

C07C 6/04
C07C 6/02

US Classification:

585646, 564509, 548473, 548477, 548479

Abstract:

The present invention generally relates to methods for performing metathesis reactions, including cross-metathesis reactions. Methods described herein exhibit enhanced activity and stereoselectivity, relative to known methods, and are useful in the synthesis of a large assortment of biologically and therapeutically significant agents.

US Patent:

8598400, Dec 3, 2013

Filed:

Feb 8, 2011

Appl. No.:

13/023400

Inventors:

Amir H. Hoveyda - Lincoln MA, US
Simon J. Meek - Newtonville MA, US
Robert V. O'Brien - Brighton MA, US
Josep Llaveria Cros - Tarragona, ES
Richard R. Schrock - Winchester MA, US

Assignee:

Massachusetts Institute of Technology - Cambridge MA
Trustees of Boston College - Chestnut Hill MA

International Classification:

C07C 6/04
C07C 6/02

US Classification:

585646, 564509, 548473, 548477, 548479

Abstract:

The present invention generally relates to methods for performing metathesis reactions, including cross-metathesis reactions. Methods described herein exhibit enhanced activity and stereoselectivity, relative to known methods, and are useful in the synthesis of a large assortment of biologically and therapeutically significant agents.

US Patent:

43584012, Nov 9, 1982

Filed:

Mar 31, 1980

Appl. No.:

6/135763

Inventors:

Robert E. O'Brien - Belmont MA
Jeanne K. Krieger - Lexington MA

Assignee:

New England Nuclear Corporation - Boston MA

International Classification:

G21F 916
G21F 914

US Classification:

252628

Abstract:

A liquid organic scintillation cocktail which is readily converted to a solid for disposal after use. Also disclosed are a method of disposal of radwaste employing the cocktail and a kit useful for practicing the method.

US Patent:

43584349, Nov 9, 1982

Filed:

Dec 19, 1979

Appl. No.:

6/105272

Inventors:

Nathan R. Tzodikov - Milton MA
Robert E. O'Brien - Belmont MA

Assignee:

New England Nuclear Corporation - Boston MA

International Classification:

A61K 4300
A61K 4900

US Classification:

424 1

Abstract:

A method and kit for stabilizing solutions of radiolabelled compound by the use of insoluble quaternary ammonium containing compounds. Also described are novel insoluble compounds having quaternary ammonium and sulfide groups for use in the present invention.

US Patent:

43905170, Jun 28, 1983

Filed:

Aug 15, 1980

Appl. No.:

6/178609

Inventors:

Robert E. O'Brien - Belmont MA
Nathan R. Tzodikov - Milton MA

Assignee:

New England Nuclear Corporation - Boston MA

International Classification:

A61K 4300
A61K 4900
B65D 7100

US Classification:

424 1

Abstract:

A method of stabilizing a solution of a radiolabeled compound comprising adding to such solution a compound having a substantially insoluble backbone, to which has been bound a quaternary ammonium group; or a water soluble primary, secondary or tertiary aliphatic amine. The present invention also includes a solution of a radiolabeled compound maintained in contact with such a compound, and as an article of manufacture, a sealed vial containing such a solution.

US Patent:

45227420, Jun 11, 1985

Filed:

Feb 25, 1982

Appl. No.:

6/352209

Inventors:

Duk H. Lee - Wellesley MA
Susan Feierberg - Watertown MA
Robert E. O'Brien - Belmont MA

Assignee:

E. I. Du Pont de Nemours and Company Inc. - Wilmington DE

International Classification:

B01D 1302
B01J 3102
C09K 1106
G21H 502

US Classification:

25230116

Abstract:

Water soluble fluors useful in enhancing images obtained in autoradiography have the general formula: [F]. sub. x [B]. sub. y [S]. sub. z F is a moiety which acts as a fluor, e. g. , a dehydro derivative of a compound which is a fluor; preferred examples include 4-(2,5-diphenyloxazolyl), 1-naphthylmethyl, 2-naphthyl, and 4-[5-(2-phenyloxazolyl)]phenyl. S is a surfactant moiety which makes the molecule hydrophilic, e. g. , dehydro derivatives of surfactants; preferred examples include polyethylene glycol derivatives, sulfonic acids or salts thereof, aryl sulfonates, amines and quaternary ammonium compounds. B is a binding moiety which chemically binds the fluor moiety F with the surfactant S, and may be a chemical bond, or a disubstituted moiety such as an alkylene, e. g. , methylene group. The variables x, y and z are integers which can generally vary from 1 to 10.

US Patent:

46456180, Feb 24, 1987

Filed:

Nov 1, 1985

Appl. No.:

6/794257

Inventors:

Duk H. Lee - Wellesley MA
Susan Feierberg - Watertown MA
Robert E. O'Brien - Belmont MA

Assignee:

E. I. Du Pont de Nemours and Company - Wilmington DE

International Classification:

C09K 1106

US Classification:

25230117

Abstract:

Water soluble fluors useful in enhancing images obtained in autoradiography have the general formula: [F]. sub. x [B]. sub. y [S]. sub. z F is a moiety which acts as a fluor, e. g. , a dehydro derivative of a compound which is a fluor; preferred examples include 4-(2,5-diphenyloxazolyl), 1-napththylmethyl, 2-napththyl, and 4-[5-(2-phenyloxazolyl)]phenyl. S is a surfactant moiety which makes the molecule hydrophilic, e. g. , dehydro derivatives of surfactants; preferred examples include polyethylene glycol derivatives, sulfonic acids or salts thereof, aryl sulfonates amines and quaternary ammonium compounds. B is a binding moiety which chemically binds the fluor moiety F with the surfactant S, and may be a chemical bond, or a disubstituted moiety such as an alkylene, e. g. , methylene group. The variables x, y and z are integers which can generally vary from 1 to 10.