Robert F O'Brien

US Patent:

8552242, Oct 8, 2013

Filed:

Feb 8, 2011

Appl. No.:

13/023400

Inventors:

Amir H. Hoveyda - Lincoln MA, US
Simon J. Meek - Newtonville MA, US
Robert V. O'Brien - Brighton MA, US
Josep Llaveria Cros - Tarragona, ES
Richard R. Schrock - Winchester MA, US

Assignee:

Massachusetts Institute of Technology - Cambridge MA
Trustees of Boston College - Chestnut Hill MA

International Classification:

C07C 6/04
C07C 6/02

US Classification:

585646, 564509, 548473, 548477, 548479

Abstract:

The present invention generally relates to methods for performing metathesis reactions, including cross-metathesis reactions. Methods described herein exhibit enhanced activity and stereoselectivity, relative to known methods, and are useful in the synthesis of a large assortment of biologically and therapeutically significant agents.

US Patent:

8598400, Dec 3, 2013

Filed:

Feb 8, 2011

Appl. No.:

13/023400

Inventors:

Amir H. Hoveyda - Lincoln MA, US
Simon J. Meek - Newtonville MA, US
Robert V. O'Brien - Brighton MA, US
Josep Llaveria Cros - Tarragona, ES
Richard R. Schrock - Winchester MA, US

Assignee:

Massachusetts Institute of Technology - Cambridge MA
Trustees of Boston College - Chestnut Hill MA

International Classification:

C07C 6/04
C07C 6/02

US Classification:

585646, 564509, 548473, 548477, 548479

Abstract:

The present invention generally relates to methods for performing metathesis reactions, including cross-metathesis reactions. Methods described herein exhibit enhanced activity and stereoselectivity, relative to known methods, and are useful in the synthesis of a large assortment of biologically and therapeutically significant agents.

US Patent:

43584012, Nov 9, 1982

Filed:

Mar 31, 1980

Appl. No.:

6/135763

Inventors:

Robert E. O'Brien - Belmont MA
Jeanne K. Krieger - Lexington MA

Assignee:

New England Nuclear Corporation - Boston MA

International Classification:

G21F 916
G21F 914

US Classification:

252628

Abstract:

A liquid organic scintillation cocktail which is readily converted to a solid for disposal after use. Also disclosed are a method of disposal of radwaste employing the cocktail and a kit useful for practicing the method.

US Patent:

43905170, Jun 28, 1983

Filed:

Aug 15, 1980

Appl. No.:

6/178609

Inventors:

Robert E. O'Brien - Belmont MA
Nathan R. Tzodikov - Milton MA

Assignee:

New England Nuclear Corporation - Boston MA

International Classification:

A61K 4300
A61K 4900
B65D 7100

US Classification:

424 1

Abstract:

A method of stabilizing a solution of a radiolabeled compound comprising adding to such solution a compound having a substantially insoluble backbone, to which has been bound a quaternary ammonium group; or a water soluble primary, secondary or tertiary aliphatic amine. The present invention also includes a solution of a radiolabeled compound maintained in contact with such a compound, and as an article of manufacture, a sealed vial containing such a solution.

US Patent:

45227420, Jun 11, 1985

Filed:

Feb 25, 1982

Appl. No.:

6/352209

Inventors:

Duk H. Lee - Wellesley MA
Susan Feierberg - Watertown MA
Robert E. O'Brien - Belmont MA

Assignee:

E. I. Du Pont de Nemours and Company Inc. - Wilmington DE

International Classification:

B01D 1302
B01J 3102
C09K 1106
G21H 502

US Classification:

25230116

Abstract:

Water soluble fluors useful in enhancing images obtained in autoradiography have the general formula: [F]. sub. x [B]. sub. y [S]. sub. z F is a moiety which acts as a fluor, e. g. , a dehydro derivative of a compound which is a fluor; preferred examples include 4-(2,5-diphenyloxazolyl), 1-naphthylmethyl, 2-naphthyl, and 4-[5-(2-phenyloxazolyl)]phenyl. S is a surfactant moiety which makes the molecule hydrophilic, e. g. , dehydro derivatives of surfactants; preferred examples include polyethylene glycol derivatives, sulfonic acids or salts thereof, aryl sulfonates, amines and quaternary ammonium compounds. B is a binding moiety which chemically binds the fluor moiety F with the surfactant S, and may be a chemical bond, or a disubstituted moiety such as an alkylene, e. g. , methylene group. The variables x, y and z are integers which can generally vary from 1 to 10.

US Patent:

46456180, Feb 24, 1987

Filed:

Nov 1, 1985

Appl. No.:

6/794257

Inventors:

Duk H. Lee - Wellesley MA
Susan Feierberg - Watertown MA
Robert E. O'Brien - Belmont MA

Assignee:

E. I. Du Pont de Nemours and Company - Wilmington DE

International Classification:

C09K 1106

US Classification:

25230117

Abstract:

Water soluble fluors useful in enhancing images obtained in autoradiography have the general formula: [F]. sub. x [B]. sub. y [S]. sub. z F is a moiety which acts as a fluor, e. g. , a dehydro derivative of a compound which is a fluor; preferred examples include 4-(2,5-diphenyloxazolyl), 1-napththylmethyl, 2-napththyl, and 4-[5-(2-phenyloxazolyl)]phenyl. S is a surfactant moiety which makes the molecule hydrophilic, e. g. , dehydro derivatives of surfactants; preferred examples include polyethylene glycol derivatives, sulfonic acids or salts thereof, aryl sulfonates amines and quaternary ammonium compounds. B is a binding moiety which chemically binds the fluor moiety F with the surfactant S, and may be a chemical bond, or a disubstituted moiety such as an alkylene, e. g. , methylene group. The variables x, y and z are integers which can generally vary from 1 to 10.