Robert G O'Brien

US Patent:

8552242, Oct 8, 2013

Filed:

Feb 8, 2011

Appl. No.:

13/023400

Inventors:

Amir H. Hoveyda - Lincoln MA, US
Simon J. Meek - Newtonville MA, US
Robert V. O'Brien - Brighton MA, US
Josep Llaveria Cros - Tarragona, ES
Richard R. Schrock - Winchester MA, US

Assignee:

Massachusetts Institute of Technology - Cambridge MA
Trustees of Boston College - Chestnut Hill MA

International Classification:

C07C 6/04
C07C 6/02

US Classification:

585646, 564509, 548473, 548477, 548479

Abstract:

The present invention generally relates to methods for performing metathesis reactions, including cross-metathesis reactions. Methods described herein exhibit enhanced activity and stereoselectivity, relative to known methods, and are useful in the synthesis of a large assortment of biologically and therapeutically significant agents.

US Patent:

8598400, Dec 3, 2013

Filed:

Feb 8, 2011

Appl. No.:

13/023400

Inventors:

Amir H. Hoveyda - Lincoln MA, US
Simon J. Meek - Newtonville MA, US
Robert V. O'Brien - Brighton MA, US
Josep Llaveria Cros - Tarragona, ES
Richard R. Schrock - Winchester MA, US

Assignee:

Massachusetts Institute of Technology - Cambridge MA
Trustees of Boston College - Chestnut Hill MA

International Classification:

C07C 6/04
C07C 6/02

US Classification:

585646, 564509, 548473, 548477, 548479

Abstract:

The present invention generally relates to methods for performing metathesis reactions, including cross-metathesis reactions. Methods described herein exhibit enhanced activity and stereoselectivity, relative to known methods, and are useful in the synthesis of a large assortment of biologically and therapeutically significant agents.

US Patent:

43584012, Nov 9, 1982

Filed:

Mar 31, 1980

Appl. No.:

6/135763

Inventors:

Robert E. O'Brien - Belmont MA
Jeanne K. Krieger - Lexington MA

Assignee:

New England Nuclear Corporation - Boston MA

International Classification:

G21F 916
G21F 914

US Classification:

252628

Abstract:

A liquid organic scintillation cocktail which is readily converted to a solid for disposal after use. Also disclosed are a method of disposal of radwaste employing the cocktail and a kit useful for practicing the method.

US Patent:

43584349, Nov 9, 1982

Filed:

Dec 19, 1979

Appl. No.:

6/105272

Inventors:

Nathan R. Tzodikov - Milton MA
Robert E. O'Brien - Belmont MA

Assignee:

New England Nuclear Corporation - Boston MA

International Classification:

A61K 4300
A61K 4900

US Classification:

424 1

Abstract:

A method and kit for stabilizing solutions of radiolabelled compound by the use of insoluble quaternary ammonium containing compounds. Also described are novel insoluble compounds having quaternary ammonium and sulfide groups for use in the present invention.

US Patent:

43905170, Jun 28, 1983

Filed:

Aug 15, 1980

Appl. No.:

6/178609

Inventors:

Robert E. O'Brien - Belmont MA
Nathan R. Tzodikov - Milton MA

Assignee:

New England Nuclear Corporation - Boston MA

International Classification:

A61K 4300
A61K 4900
B65D 7100

US Classification:

424 1

Abstract:

A method of stabilizing a solution of a radiolabeled compound comprising adding to such solution a compound having a substantially insoluble backbone, to which has been bound a quaternary ammonium group; or a water soluble primary, secondary or tertiary aliphatic amine. The present invention also includes a solution of a radiolabeled compound maintained in contact with such a compound, and as an article of manufacture, a sealed vial containing such a solution.

US Patent:

58657215, Feb 2, 1999

Filed:

Jun 5, 1996

Appl. No.:

8/658386

Inventors:

Robert R. Andrews - Norfolk MA
William Edelman - Sharon MA
Joseph A. Levendusky - Groton MA
Robert L. O'Brien - Rindge NH

Assignee:

C. R. Bard, Inc. - Murray Hill NJ

International Classification:

A61N 1362

US Classification:

600 18

Abstract:

An intra-aortic balloon pump catheter includes an inner lumen formed by a thin walled superelastic metal alloy tube, namely of nitinol, with an inside diameter sufficient for a guidewire and a small outside diameter which allows reduction of the outer lumen and related components by at least one size French while providing gas shuttle capacity between the lumens for conventional intra-aortic balloon pump operation. The outer lumen is a tube formed of co-extruded plastics to enhance the size reduction and capacity goals, with an inner nylon portion for strength and a relatively thin polyurethane outer portion for biocompatability, flexibility and compatibility for bonding to a thin polyurethane balloon. The proximal end sleeve of the balloon is stretched and then stress-relieved by heating with an internal heater on a mounting mandrel to effect a desired small diameter sizing. A radiopaque metal marker ring of nitinol also is provided to improve imaging capabilities while being compatible with the lumen materials.

US Patent:

57188610, Feb 17, 1998

Filed:

Jun 7, 1995

Appl. No.:

8/484894

Inventors:

Robert R. Andrews - Norfolk MA
William Edelman - Sharon MA
Joseph A. Levendusky - Groton MA
Peter T. Majeski - Cambridge MA
Robert L. O'Brien - Rindge NH

Assignee:

C. R. Bard, Incorporated - Murray Hill NJ

International Classification:

B29C 4114
B29C 7102

US Classification:

264235

Abstract:

A method of forming intra-aortic balloons includes forming a balloon blank having a sleeve section at its proximal end. To reduce the diameter of the sleeve section of the balloon, the sleeve section is stretched longitudinally by gripping a first portion of the balloon blank at the distal end of the sleeve section, gripping a second portion of the balloon blank at the opposite end of the sleeve section and moving at least one of the gripped portions away from the other so as to reduce the diameter of the sleeve section. A heating element is positioned within the sleeve section to relieve the stress in the sleeve after stretching, by heating the sleeve section. The sleeve section is then cooled in order to preserve the sleeve section in its reduced diameter state thereby forming an intra-aortic balloon having a balloon blank with a reduced diameter sleeve section.

US Patent:

45227420, Jun 11, 1985

Filed:

Feb 25, 1982

Appl. No.:

6/352209

Inventors:

Duk H. Lee - Wellesley MA
Susan Feierberg - Watertown MA
Robert E. O'Brien - Belmont MA

Assignee:

E. I. Du Pont de Nemours and Company Inc. - Wilmington DE

International Classification:

B01D 1302
B01J 3102
C09K 1106
G21H 502

US Classification:

25230116

Abstract:

Water soluble fluors useful in enhancing images obtained in autoradiography have the general formula: [F]. sub. x [B]. sub. y [S]. sub. z F is a moiety which acts as a fluor, e. g. , a dehydro derivative of a compound which is a fluor; preferred examples include 4-(2,5-diphenyloxazolyl), 1-naphthylmethyl, 2-naphthyl, and 4-[5-(2-phenyloxazolyl)]phenyl. S is a surfactant moiety which makes the molecule hydrophilic, e. g. , dehydro derivatives of surfactants; preferred examples include polyethylene glycol derivatives, sulfonic acids or salts thereof, aryl sulfonates, amines and quaternary ammonium compounds. B is a binding moiety which chemically binds the fluor moiety F with the surfactant S, and may be a chemical bond, or a disubstituted moiety such as an alkylene, e. g. , methylene group. The variables x, y and z are integers which can generally vary from 1 to 10.