Robert T O'Neil

US Patent:

6852522, Feb 8, 2005

Filed:

Nov 28, 2000

Appl. No.:

09/724419

Inventors:

Peter Palese - Leonia NJ, US
Adolfo Garcia-Sastre - New York NY, US
Robert O'Neil - New York NY, US

Assignee:

Mount Sinai School of Medicine of New York University - New York NY

International Classification:

C12N007/00

US Classification:

435239, 4352351, 435237, 435325

Abstract:

The present invention relates, to novel methods and substrates for the propagation of viruses. The invention relates to IFN-deficient substrates and methods for propagating viruses in these unconventional substrates. In particular, the invention relates to methods of propagating viruses in immature embryonated eggs, preferably six- to nine-day-old chicken eggs. The methods of the invention are particularly attractive for growing viruses suitable for use in vaccine and pharmaceutical formulations.

US Patent:

7494808, Feb 24, 2009

Filed:

Sep 20, 2004

Appl. No.:

10/945718

Inventors:

Peter Palese - Leonia NJ, US
Robert O'Neil - New York NY, US

Assignee:

Mount Sinai School of Medicine of New York University - New York NY

International Classification:

C12N 5/00

US Classification:

435325, 4352351

Abstract:

The present invention relates, to novel methods and substrates for the propagation of viruses. The invention relates to IFN-deficient substrates and methods for propagating viruses in these unconventional substrates. In particular, the invention relates to methods of propagating viruses in immature embryonated eggs, preferably six- to nine-day-old chicken eggs. The methods of the invention are particularly attractive for growing viruses suitable for use in vaccine and pharmaceutical formulations.

US Patent:

20090203114, Aug 13, 2009

Filed:

Feb 2, 2009

Appl. No.:

12/364243

Inventors:

Peter Palese - Leonia NJ, US
Adolfo Garcia-Sastre - New York NY, US
Robert E. O'Neil - New York NY, US

International Classification:

C12N 7/00

US Classification:

4352351

Abstract:

The present invention relates, to novel methods and substrates for the propagation of viruses. The invention relates to IFN-deficient substrates and methods for propagating viruses in these unconventional substrates. In particular, the invention relates to methods of propagating viruses in immature embryonated eggs, preferably six- to nine-day-old chicken eggs. The methods of the invention are particularly attractive for growing viruses suitable for use in vaccine and pharmaceutical formulations.

US Patent:

20100233785, Sep 16, 2010

Filed:

Feb 23, 2009

Appl. No.:

12/391172

Inventors:

Sabine Brandt - Illmitz, AT
Thomas Muster - Vienna, AT
Robert O'Neil - Pearl River NY, US
Andrej Egorov - Vienna, AT
Peter Palese - Leonia NJ, US
Adolfo Garcia-Sastre - New York NY, US

International Classification:

C12N 7/04

US Classification:

435236

Abstract:

The present invention relates, to novel methods and substrates for the propagation of viruses. The invention relates to IFN-deficient substrates and methods for propagating viruses in these unconventional substrates. In particular, the invention relates to methods of propagating viruses in immature embryonated eggs, preferably six- to nine-day-old chicken eggs. The methods of the invention are particularly attractive for growing viruses suitable for use in vaccine and pharmaceutical formulations.

US Patent:

20210096306, Apr 1, 2021

Filed:

Dec 10, 2020

Appl. No.:

17/118430

Inventors:

- Cheshire CT, US
Boby Joseph - Shrewsbury MA, US
David G. Stone - Irvine CA, US
Aristito Lorenzo - Plantsville CT, US
Ronald M. Plante - Prospect CT, US
Phuc Minh Ly - Waterbury CT, US
Robert O'Neil - Bethel CT, US
John R. Lagana - West Nyack NY, US

International Classification:

G02B 6/38
H04L 12/24
G02B 6/44

Abstract:

A connectivity appliance that can interconnect, optical fiber communication paths of one fiber density to optical fiber communication paths of a different density, for either breakout or aggregation functionality is provided. The connectivity appliance that can interconnect high density connectors, e.g., multi-fiber connectors, to a plurality of low density connectors, e.g., single fiber optic connectors. The connectivity appliance can determine the presence of connectors inserted into the connectivity appliance adapters, determine the characteristics of the cables and connectors inserted into the connectivity appliance and/or in close proximity to the connectivity appliance. Each connector on the connectivity appliances can have one or more associated indicators, e.g., LEDs, on either the front panel or the rear panel that is in close proximity to the relevant adapter and that provides visual indications associated with the connectors.

US Patent:

20180259722, Sep 13, 2018

Filed:

Mar 7, 2018

Appl. No.:

15/914918

Inventors:

- Cheshire CT, US
Boby Joseph - Shrewsbury MA, US
David G. Stone - Irvine CA, US
Aristito Lorenzo - Plantsville CT, US
Ronald M. Plante - Prospect CT, US
Phuc Minh Ly - Waterbury CT, US
Robert O'Neil - Bethel CT, US
John R. Lagana - West Nyack NY, US

International Classification:

G02B 6/38
G02B 6/44

Abstract:

A connectivity appliance that can interconnect, optical fiber communication paths of one fiber density to optical fiber communication paths of a different density, for either breakout or aggregation functionality is provided. The connectivity appliance that can interconnect high density connectors, e.g., multi-fiber connectors, to a plurality of low density connectors, e.g., single fiber optic connectors. The connectivity appliance can determine the presence of connectors inserted into the connectivity appliance adapters, determine the characteristics of the cables and connectors inserted into the connectivity appliance and/or in close proximity to the connectivity appliance. Each connector on the connectivity appliances can have one or more associated indicators, e.g., LEDs, on either the front panel or the rear panel that is in close proximity to the relevant adapter and that provides visual indications associated with the connectors.