Robert E Pearson

US Patent:

20090174551, Jul 9, 2009

Filed:

Jan 7, 2008

Appl. No.:

12/008099

Inventors:

William Vincent Quinn - Crofton MD, US
Christopher Joseph Clark - North Potomac MD, US
Robert William Pearson - Rockville MD, US
Andrey Sergeevich Mikhalchuk - Germantown MD, US

International Classification:

G08B 21/00
G06F 15/16
H04L 9/32
G06Q 30/00

US Classification:

340540, 709224, 726 1, 705 1

Abstract:

Methods and apparatus for evaluating Internet activity are disclosed. One embodiment of the invention pertains to a child using the Internet and a parent inspecting said child's activity on the Internet, which enables said parent to intervene if said child's Internet activity is inappropriate.

US Patent:

20110275061, Nov 10, 2011

Filed:

Mar 20, 2008

Appl. No.:

12/531508

Inventors:

Kristin Weidemaier - Raleigh NC, US
Christian Sandmann - Raleigh NC, US
W. Shannon Dillmore - Raleigh NC, US
James L. Schram - Knightdale NC, US
W. William Stewart - Cary NC, US
Robert E. Pearson - Durham NC, US
Helen Hsieh - Durham NC, US
Steven Keith - Chapel Hill NC, US
Rajendra R. Bhat - Raleight NC, US
Andrea Liebmann-Vinson - Wake Forest NC, US
Adam Craig Curry - Raleigh NC, US
Alexander G. Lastovich - Raleigh NC, US

International Classification:

G01N 21/65
C12Q 1/68
C12Q 1/02
G01N 21/75
C07F 19/00
C07K 17/00
C07F 1/12
G01N 30/00
B29C 35/08
C12Q 1/00
G01N 33/53
B82Y 15/00

US Classification:

435 61, 436501, 435 405, 435 29, 556 9, 5303913, 546 2, 422 69, 425 3, 264460, 977773, 977902, 977810

Abstract:

Disclosed herein are diagnostic assays using surface enhanced Raman spectroscopy (SERS)-active particles, including liquid-based assays; magnetic capture assays; microparticle-nanoparticle satellite structures for signal amplification in an assay; composite SERS-active particles useful for enhanced detection of targets; and sample tubes and processes for using the same.

US Patent:

59167793, Jun 29, 1999

Filed:

May 8, 1997

Appl. No.:

8/854041

Inventors:

Robert E. Pearson - Durham NC
Julie A. Dickson - Raleigh NC
Majid Mehrpouyan - San Jose CA

Assignee:

Becton, Dickinson and Company - Franklin Lakes NJ

International Classification:

C12P 1934
C07H 2100

US Classification:

435 912

Abstract:

Strand Displacement Amplification has been adapted to reverse transcription amplification of RNA targets. The method of the invention is referred to as reverse transcription SDA (rtSDA) and may be performed as a two-step process or as a one-step process in which cDNA copies of an RNA target sequence are generated and amplified concurrently. In the one-step process, rtSDA reaction conditions are such that a conventional reverse transcriptase and a DNA-dependent polymerase function together in a single reaction to produce cDNA and amplify it.

US Patent:

54767687, Dec 19, 1995

Filed:

Mar 10, 1995

Appl. No.:

8/402282

Inventors:

Robert E. Pearson - Durham NC
Julie A. Dickson - Raleigh NC
Paul T. Hamilton - Cary NC
Michael C. Little - Raleigh NC
Wayne F. Beyer - Bahama NC

Assignee:

Becton, Dickinson and Company - Franklin Lakes NJ

International Classification:

C12Q 168
C12P 1934
C07H 2102
C07H 2104

US Classification:

435 6

Abstract:

Mycobacteriophage DS6A has been characterized and found to specifically infect all species of the TB complex, without any detectable infection of mycobacteria species other than those of the TB complex. DNA sequence analysis revealed several potential open reading frames, including one encoding a protein analogous to gp37 of mycobacteriophage L5 and a second encoding a protein with significant homology to the S. coelicolor DNA polymerase. beta. subunit. Based on the DNA sequence analysis, cloning sites can be identified for insertion of reporter genes, making DS6A useful as a reporter phage for specific detection and identification of species of the TB complex.

US Patent:

56121822, Mar 18, 1997

Filed:

Mar 10, 1995

Appl. No.:

8/402066

Inventors:

Robert E. Pearson - Durham NC
Julie A. Dickson - Raleigh NC
Paul T. Hamilton - Cary NC
Michael C. Little - Raleigh NC
Wayne F. Beyer - Bahama NC

Assignee:

Becton, Dickinson and Company - Franklin Lakes NJ

International Classification:

C07K 1600
C12Q 168
A61K 3902

US Classification:

435 6

Abstract:

Mycobacteriophage DS6A has been characterized and found to specifically infect all species of the TB complex, without any detectable infection of mycobacteria species other than those of the TB complex. DNA sequence analysis revealed several potential open reading frames, including one encoding a protein analogous to gp37 of mycobacteriophage L5 and a second encoding a protein with significant homology to the S. coelicolor DNA polymerase. beta. subunit. Based on the DNA sequence analysis, cloning sites can be identified for insertion of reporter genes, making DS6A useful as a reporter phage for specific detection and identification of species of the TB complex.

US Patent:

55829694, Dec 10, 1996

Filed:

Jul 27, 1995

Appl. No.:

8/508004

Inventors:

Robert E. Pearson - Durham NC
Julie A. Dickson - Raleigh NC
Paul T. Hamilton - Cary NC
Michael C. Little - Raleigh NC
Wayne F. Beyer - Bahama NC

Assignee:

Becton, Dickinson and Company - Franklin Lakes NJ

International Classification:

C12Q 170
C12Q 168
C12Q 116
C12N 1533

US Classification:

435 5

Abstract:

Mycobacteriophage DS6A has been characterized and found to specifically infect all species of the TB complex, without any detectable infection of mycobacteria species other than those of the TB complex. DNA sequence analysis revealed several potential open reading frames, including one encoding a protein analogous to gp37 of mycobacteriophage L5 and a second encoding a protein with significant homology to the S. coelicolor DNA polymerase. beta. subunit. Based on the DNA sequence analysis, cloning sites can be identified for insertion of reporter genes, making DS6A useful as a reporter phage for specific detection and identification of species of the TB complex.

US Patent:

56331592, May 27, 1997

Filed:

Mar 10, 1995

Appl. No.:

8/402068

Inventors:

Robert E. Pearson - Durham NC
Julie A. Dickson - Raleigh NC
Paul T. Hamilton - Cary NC
Michael C. Little - Raleigh NC
Wayne F. Beyer - Bahama NC

Assignee:

Becton, Dickinson and Company - Franklin Lakes NJ

International Classification:

C12N 912

US Classification:

435194

Abstract:

Mycobacteriophage DS6A has been characterized and found to specifically infect all species of the TB complex, without any detectable infection of mycobacteria species other than those of the TB complex. DNA sequence analysis revealed several potential open reading frames, including one encoding a protein analogous to gp37 of mycobacteriophage L5 and a second encoding a protein with significant homology to the S. coelicolor DNA polymerase. beta. subunit. Based on the DNA sequence analysis, cloning sites can be identified for insertion of reporter genes, making DS6A useful as a reporter phage for specific detection and identification of species of the TB complex.

US Patent:

20180059118, Mar 1, 2018

Filed:

Sep 22, 2017

Appl. No.:

15/712972

Inventors:

- Franklin Lakes NJ, US
Christian Sandmann - Wayne NJ, US
William Shannon Dillmore - Raleigh NC, US
James L. Schram - Knightdale NC, US
W. William Stewart - Cary NC, US
Robert E. Pearson - Durham NC, US
Helen Hsieh - Durham NC, US
Steven Keith - Chapel Hill NC, US
Rajendra R. Bhat - Raleigh NC, US
Andrea Liebmann-Vinson - Wake Forest NC, US
Adam Craig Curry - Raleigh NC, US
Alexander G. Lastovich - Raleigh NC, US

Assignee:

BECTON DICKINSON AND COMPANY - Franklin Lakes NJ

International Classification:

G01N 33/58
G01N 21/65
G01N 33/543

Abstract:

Disclosed herein are diagnostic assays using surface enhanced Raman spectroscopy (SERS)-active particles, including liquid-based assays; magnetic capture assays; microparticle-nanoparticle satellite structures for signal amplification in an assay; composite SERS-active particles useful for enhanced detection of targets; and sample tubes and processes for using the same.