Robert J Powers

US Patent:

6684162, Jan 27, 2004

Filed:

Jan 25, 2001

Appl. No.:

09/770834

Inventors:

Kevin Delos Parris - Auburndale MA
William Stuart Somers - Cambridge MA
Amy Szepui Tam - Framingham MA
Laura Long Lin - Weston MA
Mark Lloyd Stahl - Lexington MA
Robert Powers - Westford MA

Assignee:

Wyeth - Madison NY
Millennium Pharmaceuticals, Inc. - Cambridge MA

International Classification:

G06F 1900

US Classification:

702 27, 436 4, 435 71, 435 72

Abstract:

This invention is directed to the crystal structure of Acyl Carrier Protein Synthase (ACPS) complexed with Acyl Carrier Protein (ACP), the solution structure of ACP, and to the use of these structures in rational drug design methods to identify agents that may interact with active sites of ACPS and ACP, and to the testing of these agents to identify agents that may represent novel antibiotics.

US Patent:

20010046684, Nov 29, 2001

Filed:

Feb 21, 2001

Appl. No.:

09/789345

Inventors:

Robert Powers - Westford MA, US
Franklin Moy - Arlington MA, US
Marshall Siegel - Fair Lawn NJ, US
Dominick Mobilio - Warren NJ, US

International Classification:

G01N033/53
G06F019/00

US Classification:

435/007100, 702/019000

Abstract:

The present invention provides methods of structure-based drug design using mass spectrometry/NMR.

US Patent:

20020046394, Apr 18, 2002

Filed:

Dec 6, 2000

Appl. No.:

09/731678

Inventors:

Sung-Hee Do - Lexington MA, US
Nam suh - Sudbury MA, US
Robert Powers - Boston MA, US
Derrick Tate - Somerville MA, US

International Classification:

G06F009/44

US Classification:

717/108000

Abstract:

A system and method for producing software code is provided. In particular, a new software design methodology is provided that is based on axiomatic design theory. In one aspect, axiomatic design theory is adapted for use in designing object-oriented software programs. This methodology overcomes the shortcomings of various software design strategies including extensive software development and debugging time and the need for extensive maintenance. Because traditional software design strategies are not heuristic and do not provide basic principles for the development of good software systems, bad design habits produce poor quality software. A design framework using axiomatic design for software overcomes many of the shortcomings of current software design techniques: high maintenance costs, limited reusability, the need for extensive debugging and testing, poor documentation, and limited extensibility of the software, all of which result in high development cost of software.

US Patent:

20030186413, Oct 2, 2003

Filed:

Aug 29, 2001

Appl. No.:

09/942055

Inventors:

Robert Powers - Westford MA, US
Franklin Moy - Arlington MA, US

Assignee:

American Home Products Corporation - Madison NJ

International Classification:

C12N009/10
G06F019/00
G01N033/48
G01N033/50

US Classification:

435/193000, 702/019000

Abstract:

The present invention provides a solution structure of free RGS4 determined using NMR techniques. The structure includes a G binding site and an allosteric binding site. The structural information provided can be employed to identify, select or design agonists and antagonists of RGS4 activity. The invention includes two dimensional and three dimensional models and representations of the structure of free RGS4 based upon structural coordinates that are provided that are useful in the methods described.

US Patent:

20040078147, Apr 22, 2004

Filed:

Nov 19, 2003

Appl. No.:

10/717138

Inventors:

Kevin Parris - Auburndale MA, US
William Somers - Cambridge MA, US
Amy Tam - Medford MA, US
Laura Lin - Weston MA, US
Mark Stahl - Lexington MA, US
Robert Powers - Westford MA, US

International Classification:

G06F019/00
G01N033/48
G01N033/50
C12N009/10

US Classification:

702/019000, 435/193000

Abstract:

This invention is directed to the crystal structure of Acyl Carrier Protein Synthase (ACPS) complexed with Acyl Carrier Protein (ACP), the solution structure of ACP, and to the use of these structures in rational drug design methods to identify agents that may interact with active sites of ACPS and ACP, and to the testing of these agents to identify agents that may represent novel antibiotics.

US Patent:

20040082075, Apr 29, 2004

Filed:

Oct 25, 2002

Appl. No.:

10/280899

Inventors:

Robert Powers - Westford MA, US

International Classification:

G01N024/00
G01N033/68

US Classification:

436/173000, 436/086000, 435/007100, 435/006000

Abstract:

Provided are methods of evaluating binding or a compound to a biomolecule. The methods utilize 1D NMR of the compound and 1D or 2D NMR of the biomolecule-compound mixture, along with 2D HSQC or TROSY methodology if a biomolecule-compound complex is formed. These methods are useful for evaluating biomolecule binding with more than one compound, e.g., a library of compounds, either individually or in mixtures. The methods are also useful for NMR evaluation of the effects of competition between a compound and a known binder such as an inhibitor of biomolecule activity.

US Patent:

D2798727, Jul 30, 1985

Filed:

Aug 22, 1983

Appl. No.:

6/524874

Inventors:

Hugh P. Thornton - Acton MA
Robert B. Powers - Norwell MA

Assignee:

American District Telegraph Company - Jersey City NJ

US Classification:

D10106

US Patent:

D2797690, Jul 23, 1985

Filed:

Aug 19, 1983

Appl. No.:

6/524589

Inventors:

Hugh P. Thornton - Acton MA
Robert B. Powers - Norwell MA

Assignee:

American District Telegraph Company - Jersey City NJ

US Classification:

D10106