Robert J Powers

US Patent:

20010046684, Nov 29, 2001

Filed:

Feb 21, 2001

Appl. No.:

09/789345

Inventors:

Robert Powers - Westford MA, US
Franklin Moy - Arlington MA, US
Marshall Siegel - Fair Lawn NJ, US
Dominick Mobilio - Warren NJ, US

International Classification:

G01N033/53
G06F019/00

US Classification:

435/007100, 702/019000

Abstract:

The present invention provides methods of structure-based drug design using mass spectrometry/NMR.

US Patent:

20020046394, Apr 18, 2002

Filed:

Dec 6, 2000

Appl. No.:

09/731678

Inventors:

Sung-Hee Do - Lexington MA, US
Nam suh - Sudbury MA, US
Robert Powers - Boston MA, US
Derrick Tate - Somerville MA, US

International Classification:

G06F009/44

US Classification:

717/108000

Abstract:

A system and method for producing software code is provided. In particular, a new software design methodology is provided that is based on axiomatic design theory. In one aspect, axiomatic design theory is adapted for use in designing object-oriented software programs. This methodology overcomes the shortcomings of various software design strategies including extensive software development and debugging time and the need for extensive maintenance. Because traditional software design strategies are not heuristic and do not provide basic principles for the development of good software systems, bad design habits produce poor quality software. A design framework using axiomatic design for software overcomes many of the shortcomings of current software design techniques: high maintenance costs, limited reusability, the need for extensive debugging and testing, poor documentation, and limited extensibility of the software, all of which result in high development cost of software.

US Patent:

20030013851, Jan 16, 2003

Filed:

May 16, 2002

Appl. No.:

10/150874

Inventors:

Robert Powers - Westfield MA, US
Michelle Catino - Medford MA, US
Chu-Lai Hsiao - Waltham MA, US
Karl Malakian - Boxborough MA, US
Franklin Moy - Arlington MA, US
James Wilhelm - Boston MA, US

International Classification:

G06F019/00
G01N033/48
G01N033/50
C07K014/54

US Classification:

530/351000, 702/019000

Abstract:

The present invention relates to the three dimensional solution structure of interleukin-13 (IL-13), as well as the identification and characterization of various binding active sites of IL-13. Also provided for by the present invention are methods of utilizing the three dimensional structure for the design and selection of potent and selective agents that interact with IL-13.

US Patent:

20030186413, Oct 2, 2003

Filed:

Aug 29, 2001

Appl. No.:

09/942055

Inventors:

Robert Powers - Westford MA, US
Franklin Moy - Arlington MA, US

Assignee:

American Home Products Corporation - Madison NJ

International Classification:

C12N009/10
G06F019/00
G01N033/48
G01N033/50

US Classification:

435/193000, 702/019000

Abstract:

The present invention provides a solution structure of free RGS4 determined using NMR techniques. The structure includes a G binding site and an allosteric binding site. The structural information provided can be employed to identify, select or design agonists and antagonists of RGS4 activity. The invention includes two dimensional and three dimensional models and representations of the structure of free RGS4 based upon structural coordinates that are provided that are useful in the methods described.

US Patent:

20040082075, Apr 29, 2004

Filed:

Oct 25, 2002

Appl. No.:

10/280899

Inventors:

Robert Powers - Westford MA, US

International Classification:

G01N024/00
G01N033/68

US Classification:

436/173000, 436/086000, 435/007100, 435/006000

Abstract:

Provided are methods of evaluating binding or a compound to a biomolecule. The methods utilize 1D NMR of the compound and 1D or 2D NMR of the biomolecule-compound mixture, along with 2D HSQC or TROSY methodology if a biomolecule-compound complex is formed. These methods are useful for evaluating biomolecule binding with more than one compound, e.g., a library of compounds, either individually or in mixtures. The methods are also useful for NMR evaluation of the effects of competition between a compound and a known binder such as an inhibitor of biomolecule activity.

US Patent:

D2798727, Jul 30, 1985

Filed:

Aug 22, 1983

Appl. No.:

6/524874

Inventors:

Hugh P. Thornton - Acton MA
Robert B. Powers - Norwell MA

Assignee:

American District Telegraph Company - Jersey City NJ

US Classification:

D10106

US Patent:

43397484, Jul 13, 1982

Filed:

Apr 8, 1980

Appl. No.:

6/138311

Inventors:

John K. Guscott - Lynnfield MA
Robert Powers - Norwell MA

Assignee:

American District Telegraph Company - New York NY

International Classification:

G02B 510
G08B 1318

US Classification:

340555

Abstract:

A passive infrared detection system which exhibits a consistent optical aperture and sensitivity over different operating ranges. The system includes a mirror assembly having a plurality of spherical segments arranged in two or more ranks, each corresponding to a different operating range. Each mirror segment is disposed at its respective focal length from a detector, and is of a size and configuration to provide an intended optical aperture to achieve uniform detection sensitivity irrespective of the range of the target.

US Patent:

51685248, Dec 1, 1992

Filed:

Aug 17, 1989

Appl. No.:

7/395449

Inventors:

John P. Kroeker - Beverly MA
Robert L. Powers - Topsfield MA

Assignee:

Eliza Corporation - Beverly MA

International Classification:

G10L 500

US Classification:

381 43

Abstract:

A phoneme estimator in a speech-recognition system includes energy detect circuitry for detecting the segments of a speech signal that should be analyzed for phoneme content. Speech-element processors then process the speech signal segments, calculating nonlinear (powers and products) representations of the segments. The nonlinear representation data is applied to speech-element modeling circuitry which reduces the data through speech element specific modeling. The reduced data are then subjected to further nonlinear processing. The results of the further nonlinear processing are again applied to speech-element modeling circuitry, producing phoneme isotype estimates. The phoneme isotype estimates are rearranged and consolidated, that is, the estimates are uniformly labeled and duplicate estimates are consolidated, forming estimates of words or phrases containing minimal numbers of phonemes. The estimates may then be compared with stored words or phrases to determine what was spoken.