Robert V Reddick

US Patent:

59938048, Nov 30, 1999

Filed:

Dec 31, 1996

Appl. No.:

8/775413

Inventors:

Marjorie S. Read - Durham NC
Robert L. Reddick - Durham NC
Arthur P. Bode - Greenville NC

Assignee:

The University of North Carolina at Chapel Hill - Chapel Hill NC
East Caroline University - Greenville NC

International Classification:

A61K 3518

US Classification:

424 9372

Abstract:

Fixed-dried human blood platelets and processes for preparing the same are disclosed. The platelets, upon reconstitution: adhere to thrombogenic surfaces; do not adhere to non-thrombogenic surfaces; undergo shape change (spreading) upon adhering to a thrombogenic surface; adhere to one another to form a hemostatic plug upon adhering to a thrombogenic surface; and release their granular contents. Pharmaceutical formulations containing the same are also disclosed. The platelets are preferably fixed by means of a fixative such as formaldehyde, paraformaldehyde, or glutaraldehyde, or fixed by means of a permanganate fixate. The platelets are preferably dried by lyophilization.

US Patent:

59026081, May 11, 1999

Filed:

Dec 31, 1996

Appl. No.:

8/775287

Inventors:

Marjorie S. Read - Durham NC
Robert L. Reddick - Durham NC
Arthur P. Bode - Greenville NC

Assignee:

University of North Carolina at Chapel Hill - Chapel Hill NC
East Carolina University - Greenville NC

International Classification:

A61K35/14;35/18

US Classification:

424532

Abstract:

Fixed-dried human blood platelets and processes for preparing them are disclosed. The platelets, upon reconstitution: adhere to thrombogenic surfaces; do not adhere to non-thrombogenic surfaces; undergo shape change (spreading) upon adhering to a thrombogenic surface; adhere to one another to form a hemostatic plug upon adhering to a thrombogenic surface; and release their granular contents. Surgical aids containing such platelets are also disclosed. The platelets are preferably fixed by a fixative such as formaldehyde, paraformaldehyde, or glutaraldehyde, or fixed by a permanganate fixate. The platelets are preferably dried by lyophilization.

US Patent:

56519664, Jul 29, 1997

Filed:

Nov 28, 1994

Appl. No.:

8/325424

Inventors:

Marjorie S. Read - Durham NC
Robert L. Reddick - Durham NC
Arthur P. Bode - Greenville NC

Assignee:

The University of North Carolina at Chapel Hill - Chapel Hill NC

International Classification:

A61K 3518
A61K 3514

US Classification:

424 9372

Abstract:

Fixed-dried human blood platelets and processes for preparing the same are disclosed. The platelets, upon reconstitution: adhere to thrombogenic surfaces; do not adhere to non-thrombogenic surfaces; undergo shape change (spreading) upon adhering to a thrombogenic surface; adhere to one another to form a hemostatic plug upon adhering to a thrombogenic surface; and release their granular contents. Pharmaceutical formulations containing the same are also disclosed. The platelets are preferably fixed by means of a fixative such as formaldehyde, paraformaldehyde, or glutaraldehyde, or fixed by means of a permanganate fixate. The platelets are preferably dried by lyophilization.