Robert Alan Reese

US Patent:

47466120, May 24, 1988

Filed:

Oct 12, 1984

Appl. No.:

6/660478

Inventors:

Harold A. Stanley - La Jolla CA
Robert T. Reese - San Diego CA

Assignee:

Scripps Clinic & Research Foundation - La Jolla CA

International Classification:

C12N 500
C12N 1500
C07K 1504

US Classification:

43524027

Abstract:

Aotus trivirgatus interspecies hybridomas, their monoclonal receptors and methods of preparation and use are disclosed. The hybridomas are prepared by fusion of Aotus antibody-producing cells with myeloma cells containing about an equal number of chromosomes per cell. The resulting hybridomas are stable and secrete Aotus receptors. Particular receptors that immunoreact with antigenic proteins of Plasmodium falciparum shizonts and merozoites are disclosed.

US Patent:

48352594, May 30, 1989

Filed:

Sep 14, 1984

Appl. No.:

6/650810

Inventors:

Robert T. Reese - San Diego CA
Randall F. Howard - San Diego CA
Harold A. Stanley - La Jolla CA

Assignee:

Scripps Clinic and Research Foundation - La Jolla CA

International Classification:

C07K 1514

US Classification:

530395

Abstract:

The invention comprises antigenic glycoproteins substantially similar to antigenic glycoproteins present on the surface of the merozoite form of Plasmodium falciparum, including glycoproteins of molecular weights of about 56,000 and about 50,000. The invention also comprises monoclonal antibodies which bind to the glycoproteins of the invention, hybridoma cell lines which are capable of producing these monoclonal antibodies, and vaccines and vaccine compositions comprising these glycoproteins or epitopes substantially similar to or cross reactive with these glycoproteins or genes or gene fragments encoding such epitopes.

US Patent:

50195115, May 28, 1991

Filed:

Apr 14, 1988

Appl. No.:

7/183456

Inventors:

Robert T. Reese - San Diego CA
Harold A. Stanley - La Jolla CA

International Classification:

C12N 500
A61K 3514
C07K 300
C07K 1300

US Classification:

43524027

Abstract:

Monoclonal antibodies are disclosed that react with an antigenic polypeptide having a molecular weight of approximately 45,000 that is expressed in the cell membrane of P. falciparun-infected erythrocytes. The antibodies were raised using the Honduras CDC isolate, and can be used for diagnostic purposes. The hybridoma producing the monoclonal antibodies is also disclosed.

US Patent:

49786210, Dec 18, 1990

Filed:

Jun 1, 1989

Appl. No.:

7/366191

Inventors:

Feroza Ardeshir - San Diego CA
Janette E. Flint - Del Mar CA
Robert T. Reese - La Jolla CA

Assignee:

Scripps Clinic and Research Foundation - La Jolla CA

International Classification:

C12N 100
C12N 1500
C12N 122
C12P 2106

US Classification:

435243

Abstract:

DNA sequences are described which encode Plasmodium falciparum merozoite antigenic surface proteins and protein fragments. Corresponding recombinant plasmids and transformed bacterial strains are described. The proteins and fragments have utility for immunological and diagnostic purposes.

US Patent:

50081985, Apr 16, 1991

Filed:

May 30, 1989

Appl. No.:

7/358663

Inventors:

Robert T. Reese - San Diego CA
Harold A. Stanley - La Jolla CA

Assignee:

Scripps Clinic and Research Foundation - La Jolla CA

International Classification:

C12N 500
A61K 3514
C07K 300
C07K 1300

US Classification:

43524027

Abstract:

The invention comprises antigenic glycoproteins substantially similar to antigenic glycoproteins present on the surface of the merozoite form of Plasmodium falciparum, including glycoproteins of molecular weights of about 56,000 present in the Geneva and FVO isolates and about 50,000 that is present in the Honduras I/CDC, Indochina 1, Kenya and Tanzania I isolates. The invention also comprises monoclonal antibodies 4-8-5D (HB 8938) which bind to the 56,000 glycoprotein of the invention, a hybridoma cell line that is capable of producing these monoclonal antibodies, and vaccines and vaccine compositions comprising these glycoproteins or epitopes substantially similar to or cross reactive with these glycoproteins or genes or gene fragments encoding such epitopes.