Robert C Reid

US Patent:

7033608, Apr 25, 2006

Filed:

Jun 22, 1999

Appl. No.:

09/337945

Inventors:

John E. Van Hamont - Fort Meade MD, US
Phil Friden - Bedford MA, US
Robert H. Reid - Fairfield PA, US
F. Donald Roberts - Dover MA, US
Charles E. McQueen - Olney MD, US
Jean A. Setterstrom - Silver Spring MD, US

Assignee:

The United States of America as represented by the Secretary of the Army - Washington DC

International Classification:

A61K 9/14
A61K 9/16
A61K 9/50

US Classification:

424490, 424489, 424491, 424493, 424496, 424501

Abstract:

Novel burst-free, sustained release biocompatible and biodegrable microcapsules which can be programmed to release their active core for variable durations ranging from 1–100 days in an aqueous physiological environment. The microcapsules are comprised of a core of polypeptide or other biologically active agent encapsulated in a matrix of poly(lactide/glycolide) copolymer as a blend of uncapped (free carboxyl end group) and end-capped forms ranging in ratios from 100/0 to 1/99.

US Patent:

RE40786, Jun 23, 2009

Filed:

Jun 2, 2000

Appl. No.:

09/586747

Inventors:

Paul R. Burnett - Silver Spring MD, US
John E. van Hamont - West Point NY, US
Robert H. Reid - Kensington MD, US
Jean A. Setterstrom - Alpharetta GA, US
Thomas C. Van Cott - Brookeville MD, US
Deborah L. Birx - Potomac MD, US

Assignee:

The United States of America as represented by the Secretary of the Army - Washington DC

International Classification:

A61K 38/00
A61K 9/00
A61K 9/16
A61K 9/50
C07K 14/195
C07K 14/245

US Classification:

424499, 424422, 424426, 424455, 424486, 424488

Abstract:

This invention relates to parenteral and mucosal vaccines against diseases caused by intercellular pathogens using antigens encapsulated within a biodegradable-biocompatible microspheres(matrix).

US Patent:

RE41157, Mar 2, 2010

Filed:

Nov 30, 1999

Appl. No.:

09/451321

Inventors:

Robert H. Reid - Kensington MD, US
John E. VanHamont - Universal City TX, US
William R. Brown - Denver CO, US
Edgar C. Boedeker - Placitas NM, US
Curt Thies - Ballwin MO, US

Assignee:

The United States of America as represented by the Secretary of the Army - Washington DC

International Classification:

A61K 9/16
A61K 9/50
A61K 9/14
A61K 47/30

US Classification:

424491, 424493, 424486, 424497, 424499, 424501, 5147881, 514965

US Patent:

20030161889, Aug 28, 2003

Filed:

Aug 20, 2002

Appl. No.:

10/224125

Inventors:

Robert Reid - Kensington MD, US
Jean Setterstrom - Alpharetta GA, US
Edgar Boedeker - Crownsville MD, US
John VanHamont - Fort Meade MD, US
Charles McQueen - Olney MD, US
Frederick Cassels - Ellicott City MD, US

International Classification:

A61K039/00
A61K009/50

US Classification:

424/491000, 424/184100

Abstract:

This invention relates to an immunostimulating composition comprising encapsulating microspheres, which may contain a pharmaceutically-acceptable adjuvant, wherein said microspheres having a diameter between 1 nanometer (nm) to 10 microns (um) are comprised of (a) a biodegradable-biocompatible poly(DL-lactide-co-glycolide) as the bulk matrix, wherein the relative ratio between the amount of lactide and glycolide components are within the range of 40:60 to 0:100 and wherein said poly (DL-lactide-co-glycolide) is present in an uncapped form and an end-capped form wherin a ratio of uncapped to end-capped forms is 99/1 to 1/99, and (b) an immunogenic substance comprising Colony Factor Antigen (CFA/II), hepatitis B surface antigen (HbsAg), or a physiologically similar antigen that serves to elicit the producton of antibodies in animal subjects. The preparation of its composition and its use as a vaccine is also disclosed.

US Patent:

54179866, May 23, 1995

Filed:

Apr 10, 1992

Appl. No.:

7/867301

Inventors:

Robert H. Reid - Kensington MD
Edgar C. Boedeker - Chevy Chase MD
John E. van Hamont - Shape, BE
Jean A. Setterstrom - Takoma Park MD

Assignee:

The United States of America as represented by the Secretary of the Army - Washington DC

International Classification:

A61K 950
A61K 966
A61K 926

US Classification:

424499

Abstract:

This invention is directed to oral parenteral and intestinal vaccines and eir use against diseases caused by enteropathogenic organisms using antigens encapsulated within biodegradable-biocompatible microspheres.

US Patent:

56933436, Dec 2, 1997

Filed:

May 16, 1994

Appl. No.:

8/242960

Inventors:

Robert H. Reid - Kensington MD
John E. van Hamont - Fort Meade MD
William R. Brown - Denver CO
Egar C. Boedeker - Chevy Chase MD
Curt Thies - Ballwin MO

Assignee:

The United States of America as represented by the Secretary of the Army - Washington DC

International Classification:

A61K 916
A61K 950
A61K 4730

US Classification:

424491

Abstract:

In a solvent extraction process for preparing microspheres of a biodegrade polymer, the improvement comprising: preparing a homogenized antigen-sucrose matrix and adding a solvent to the sucrose-antigen matrix to form a solution; preparing a solution of a biodegradable polymer by adding a solvent to the polymer; adding the biodegradable polymer solution to the antigen-sucrose solution; adding an oil to the polymer-sucrose-antigen solution to form an emulsion having a controlled viscosity that corresponds to a predetermined average particle size of distributions of microspheres of biodegradable polymers; centrifuging the emulsion of controlled viscosity and removing the supernatant to obtain microspheres of a predetermined range of particle size distributions of from about 0. 5 to about 7. 0 micrometers.

US Patent:

57629650, Jun 9, 1998

Filed:

Feb 9, 1996

Appl. No.:

8/598874

Inventors:

Paul R. Burnett - Silver Spring MD
John E. Van Hamont - Ft. Meade MD
Robert H. Reid - Kensington MD
Jean A. Setterstrom - Alpharetta GA
Thomas C. Van Cott - Brookeville MD
Debrah L. Birx - Potomac MD

Assignee:

The United States of America as represented by the Secretary of the Army - Washington DC

International Classification:

A61K 900
A61K 966
A61K 914
A61F 1300

US Classification:

424499

Abstract:

This invention relates to parenteral and mucosal vaccines against diseases aused by intracellular pathogens using antigens encapsulated within a biodegradable-biocompatible microspheres(matrix).