Robert W Robey

US Patent:

6521635, Feb 18, 2003

Filed:

Jan 22, 2001

Appl. No.:

09/767594

Inventors:

Susan Bates - Bethesda MD
Robert Robey - Laurel MD

Assignee:

The United States of America as represented by the Department of Health and Human Services - Washington DC

International Classification:

A61K 31435

US Classification:

514297, 514287, 514 33

Abstract:

This invention provides methods that are useful for inhibiting a MXR transporter in a cell overexpressing a MXR gene but not overexpressing a Pgp gene by contacting the cell with an acridine derivative. The invention also provides for a method of treating a mammal suffering from a cancer, which overexpressing a MXR gene but not overexpress a Pgp gene, by the co-administration of a chemotherapeutic and an acridine derivative.

US Patent:

8470888, Jun 25, 2013

Filed:

Dec 29, 2008

Appl. No.:

12/811144

Inventors:

Curtis J. Henrich - Rockville MD, US
Heidi R. Bokesch - Frederick MD, US
Laura K. Cartner - Middletown MD, US
Richard W. Fuller - Fairfield PA, US
Kirk R. Gustafson - Frederick MD, US
Kentaro Takada - Yokohama, JP
James B. McMahon - Frederick MD, US
Susan E. Bates - Bethesda MD, US
Robert W. Robey - Laurel MD, US
Suneet Shukla - Rockville MD, US
Suresh V. Ambudkar - Gaithersburg MD, US
Michael C. Dean - Frederick MD, US

Assignee:

The United States of America, as represented by the Secretary, Department of Health and Human Services - Washington DC

International Classification:

A61K 31/12
C07C 59/86

US Classification:

514679, 562459

Abstract:

Disclosed are methods of enhancing the chemotherapeutic treatment of tumor cells, reducing resistance of a cancer cell to a chemotherapeutic agent, a method of inhibiting ABCG2, Pgp, or MRP1 in a mammal afflicted with cancer, and a method of increasing the bioavailability of an ABCG2 substrate drug in a mammal. The methods comprise administering effective amounts of certain compounds to the mammal, for example, a compound of the formula (I): Formula (I), wherein R, R, R, X, X, X, a, and b are as described herein. Uses of these compounds in the preparation of a medicament are also disclosed. Also disclosed are compounds of formula (II), pharmaceutical compositions comprising such compounds and uses thereof.

US Patent:

20100267652, Oct 21, 2010

Filed:

Nov 5, 2008

Appl. No.:

12/742039

Inventors:

Curtis J. Henrich - Rockville MD, US
Heidi R. Bokesch - Frederick MD, US
Susan E. Bates - Bethesda MD, US
Robert W. Robey - Laurel MD, US
Suneet Shukla - Rockville MD, US
Suresh V. Ambudkar - Gaithersburg MD, US
Michael C. Dean - Frederick MD, US
James B. McMahon - Frederick MD, US

International Classification:

A61K 31/7042
A61K 31/4985
A61K 31/519
A61K 31/4439
A61K 31/40
A61K 31/295
A61P 35/04

US Classification:

514 26, 514250, 5142621, 514341, 514418, 514501

Abstract:

Disclosed are methods of enhancing the chemotherapeutic treatment of tumor cells, reducing resistance of a cancer cell to a chemotherapeutic agent, a method of inhibiting ABCG2 or MRP1 in a mammal afflicted with cancer, and a method of increasing the bioavailability of an ABCG2 substrate drug in a mammal. The methods comprise administering peliomycin and other compounds described herein.

US Patent:

20130274323, Oct 17, 2013

Filed:

Jun 5, 2013

Appl. No.:

13/910238

Inventors:

Heidi R. Bokesch - Frederick MD, US
Laura K. Cartner - Middletown MD, US
Richard W. Fuller - Fairfield PA, US
Kirk R. Gustafson - Frederick MD, US
Kentaro Takada - Chiba, JP
James B. McMahon - Frederick MD, US
Susan E. Bates - Bethesda MD, US
Robert W. Robey - Laurel MD, US
Suneet Shukla - Rockville MD, US
Suresh V. Ambudkar - Gaithersburg MD, US
Michael C. Dean - Frederick MD, US

International Classification:

C07C 235/34
C07D 311/92
A61K 31/277
A61K 31/353
C07C 255/54
A61K 31/165

US Classification:

514455, 514622, 514524, 514454, 564170, 558414

Abstract:

Disclosed are methods of enhancing the chemotherapeutic treatment of tumor cells, reducing resistance of a cancer cell to a chemotherapeutic agent, a method of inhibiting ABCG2, Pgp, or MRP1 in a mammal afflicted with cancer, and a method of increasing the bioavailability of an ABCG2 substrate drug in a mammal. The methods comprise administering effective amounts of certain compounds to the mammal, for example, a compound of the formula (I):wherein R, R, R, X, X, X, a, and b are as described herein. Uses of these compounds in the preparation of a medicament are also disclosed. Also disclosed are compounds of formula (II), pharmaceutical compositions comprising such compounds and uses thereof.

US Patent:

20150342978, Dec 3, 2015

Filed:

Aug 10, 2015

Appl. No.:

14/822437

Inventors:

- Bethesda MD, US
Heidi R. Bokesch - Frederick MD, US
Susan E. Bates - Bethesda MD, US
Robert W. Robey - Laurel MD, US
Suneet Shukla - Rockville MD, US
Suresh V. Ambudkar - Gaithersburg MD, US
Michael C. Dean - Frederick MD, US
James B. McMahon - Frederick MD, US

Assignee:

The United States of America, as represented by the Secretary, Dept of Health and Human Services - Bethesda MD

International Classification:

A61K 31/7048
A61K 31/4985
A61K 31/28
A61K 45/06
A61K 31/519
A61K 31/4741
A61K 31/196
A61K 31/404
A61K 31/655

Abstract:

Disclosed are methods of enhancing the chemotherapeutic treatment of tumor cells, reducing resistance of a cancer cell to a chemotherapeutic agent, a method of inhibiting ABCG2 or MRP1 in a mammal afflicted with cancer, and a method of increasing the bioavailability of an ABCG2 substrate drug in a mammal. The methods comprise administering peliomycin and other compounds described herein.