Robert T Roeven

US Patent:

20050186588, Aug 25, 2005

Filed:

Oct 18, 2004

Appl. No.:

10/967711

Inventors:

Victor Lyamichev - Madison WI, US
Andrew Lukowiak - Stoughton WI, US
Nancy Jarvis - Madison WI, US
David Kurensky - Milwaukee WI, US
Hatim Allawi - Madison WI, US
Scott Law - Madison WI, US
Chad Gerber - Middleton WI, US
Robert Roeven - Stoughton WI, US
Jeff Hall - Madison WI, US

International Classification:

C12Q001/68
C12P019/34

US Classification:

435006000, 435091200

Abstract:

The present invention provides methods and routines for developing and optimizing nucleic acid detection assays for use in basic research, clinical research, and for the development of clinical detection assays. In particular, the present invention provides methods for designing oligonucleotide primers to be used in multiplex amplification reactions. The present invention also provides methods to optimize multiplex amplification reactions. The present invention also provides methods for combined target and signal generation assays.

US Patent:

20060147938, Jul 6, 2006

Filed:

Nov 14, 2003

Appl. No.:

10/713653

Inventors:

Molly Accola - Madison WI, US
Susan Wigdal - Madison WI, US
Andrea Mast - Oregon WI, US
Christian Bartholomay - Madison WI, US
Robert Kwiatkowski - Verona WI, US
Vincent Tevere - Madison WI, US
Hon Ip - Madison WI, US
Kathleen Carroll - Verona WI, US
Patrick Peterson - Sun Prairie WI, US
Poonam Agarwal - Madison WI, US
Nancy Jarvis - Madison WI, US
Jeff Hall - Madison WI, US
Robert Roeven - Stoughton WI, US

Assignee:

Third Wave Technologies, Inc. - Madison WI

International Classification:

C12Q 1/68
C07H 21/04

US Classification:

435006000, 536024300

Abstract:

The present invention provides compositions and methods for the detection and characterization of mutations associated with cystic fibrosis. More particularly, the present invention provides compositions, methods and kits for using invasive cleavage structure assays (e.g. the INVADER assay) to screen nucleic acid samples, e.g., from patients, for the presence of any one of a collection of mutations in the CFTR gene associated with cystic fibrosis. The present invention also provides compositions, methods and kits for screening sets of CFTR alleles in a single reaction container.

US Patent:

20060240452, Oct 26, 2006

Filed:

Feb 13, 2006

Appl. No.:

11/352612

Inventors:

Zbigniev Skrzypczynski - Verona WI, US
Robert Roeven - Stoughton WI, US

International Classification:

C12Q 1/68
C07H 21/02
C07D 471/02

US Classification:

435006000, 536025320, 546049000, 546021000

Abstract:

The present invention relates to methods and compositions utilizing fluorescent quinacridone derivatives. In particular, the present invention relates to the use of fluorescent quinacridone derivatives for the labeling and detection of riucleic acids. The present invention thus provides improved compositions and methods for labeling biological molecules useful in the detection of nucleic acids and other biological molecules.

US Patent:

20080015112, Jan 17, 2008

Filed:

Feb 15, 2006

Appl. No.:

11/355090

Inventors:

Lance Fors - Madison WI, US
Bruce Neri - Madison WI, US
Mary Brow - Madison WI, US
Monika Indig - Madison WI, US
Robert Roeven - Stoughton WI, US

International Classification:

C40B 20/04

US Classification:

506004000

Abstract:

The present invention relates to detecting target nucleic acid sequences in pooled samples. In particular, the present invention relates to compositions and methods for detecting the presence or absence of target nucleic acid sequences (e.g. RNA virus sequences) in a pooled sample employing an INVADER detection assay. In certain embodiments, the present invention allows target nucleic acid sequence detection in pooled biological samples (e.g. pooled blood samples) without prior amplification of the target.

US Patent:

20030152942, Aug 14, 2003

Filed:

May 9, 2002

Appl. No.:

10/142283

Inventors:

Lance Fors - Madison WI, US
Bruce Neri - Madison WI, US
Mary D. Brow - Madison WI, US
Monika Indig - Madison WI, US
Robert Roeven - Stoughton WI, US

International Classification:

C12Q001/70
C12Q001/68

US Classification:

435/006000, 435/005000

Abstract:

The present invention relates to detecting target nucleic acid sequences in pooled samples. In particular, the present invention relates to compositions and methods for detecting the presence or absence of target nucleic acid sequences (e.g. RNA virus sequences) in a pooled sample employing an INVADER detection assay. In certain embodiments, the present invention allows target nucleic acid sequence detection in pooled biological samples (e.g. pooled blood samples) without prior amplification of the target.

US Patent:

20160193607, Jul 7, 2016

Filed:

Nov 25, 2014

Appl. No.:

14/916947

Inventors:

- Raheen, County Limerick, IE
David McGuire - Enniscorthy, County Wexford, IE
Robert Roeven - Stoughton WI, US

International Classification:

B01L 3/00
C12Q 1/68
G01N 35/10
B01L 7/00

Abstract:

A single-use cartridge, wherein the cartridge defines a plurality of blind bores, each blind bore defining one opening at least one of the plurality of blind bores containing two mutually immiscible liquids, both of which are immiscible with water, one of the two mutually immiscible liquids having a specific gravity greater than water and the other of the two mutually immiscible liquids having a specific gravity less than water.

US Patent:

20160102341, Apr 14, 2016

Filed:

Jun 18, 2014

Appl. No.:

14/892695

Inventors:

- Limerick, IE
Robert Roeven - Stoughton WI, US

International Classification:

C12Q 1/68
G01N 35/10
G01N 35/00

Abstract:

Methods, devices and systems for hand-tag sample liquids, encapsulating liquids and magnetic particles are disclosed.