Robert L Short

US Patent:

6776761, Aug 17, 2004

Filed:

Aug 20, 2002

Appl. No.:

10/225252

Inventors:

Thomas B. Ottoboni - Belmont CA
E. Glenn Tickner - Watsonville CA
Robert E. Short - Los Gatos CA
Ronald K. Yamamoto - San Francisco CA

Assignee:

Point Biomedical Corporation - San Carlos CA

International Classification:

A61B 814

US Classification:

600458, 600437, 600454, 424 951, 424 952

Abstract:

A composition for ultrasonic imaging is described having a microbubble population of controlled fragility. The microbubbles comprise an outer shell and a hollow core. The ratio of shell thickness to microbubble diameter is substantially similar across the population of microbubbles. A method of using such composition for imaging a fluid filled cavity, vessel or tissue is described.

US Patent:

8460637, Jun 11, 2013

Filed:

Oct 4, 2011

Appl. No.:

13/252743

Inventors:

Thomas B. Ottoboni - Belmont CA, US
Robert E. Short - Los Gatos CA, US

Assignee:

University of Pittsburgh-Of the Commonwealth System of Higher Education - Pittsburgh PA

International Classification:

A61B 8/00

US Classification:

424 95

Abstract:

Methods and suspensions are provided that are useful for preparing readily reconstitutable, dry compositions of micro- or nanospheres. The dry compositions find use in diagnostic applications such as ultrasonic imaging. The suspension includes as key ingredients one or both of t-butyl alcohol and/or an amorphous sugar (or mixture of amorphous sugar) in specified amounts that reduce aggregation of the particles comprising the suspension.

US Patent:

8486444, Jul 16, 2013

Filed:

Aug 15, 2011

Appl. No.:

13/209917

Inventors:

Thomas B. Ottoboni - Belmont CA, US
Robert E. Short - Los Gatos CA, US
Jeffrey D. Gabe - San Bruno CA, US

Assignee:

University of Pittsburgh-of the Commonwealth System of Higher Education - Pittsburg PA

International Classification:

A61B 8/00
A61K 9/127
A61K 9/14

US Classification:

424450, 424489, 424 951

Abstract:

A composition is provided accompanying nanoparticles having diameters in the range of about 100 to 800 nanometers with hollow cores and outer shells with mechanical properties such that they rupture on exposure to predetermined ultrasound energy. The composition is useful for identifying sentinel lymph nodes.

US Patent:

7267065, Sep 11, 2007

Filed:

Apr 21, 2006

Appl. No.:

11/408427

Inventors:

Robert J. Short - Laguna Beach CA, US

International Classification:

B63H 9/00
B63H 9/06

US Classification:

114 3929, 114 3932, 114 90, 1141021, 11410229

Abstract:

A lateen rigged sailing vessel having a mast; a luffspar; a boom; a pair of lateral struts; and a lateen sail, has a lower end of the mast mounted forward on the vessel and positioned on the vessel's longitudinal center line in a canted fashion raked aft. The boom is rotationally supported in a lower journal fixedly engaged medially on the vessel at the center line. The luffspar is joined pivotally with a forward end of the boom and, when rigged for sailing is positioned below and in parallel with the mast. The luffspar is rotationally supported in an upper journal wherein the upper journal, upper end of the mast, and upper ends of the pair of lateral struts are all engaged in a common fixture held in place by the mast and the lateral struts. The upper and lower journals are arranged on a common journal center line. The lower ends of the lateral struts are engaged with the vessel at the port and starboard gunnels.

US Patent:

20010008636, Jul 19, 2001

Filed:

Jul 13, 1999

Appl. No.:

09/352615

Inventors:

RONALD K. YAMAMOTO - SAN FRANCISCO CA, US
ROBERT E. SHORT - LOS GATOS CA, US

Assignee:

POINT BIOMEDICAL CORPORATION

International Classification:

A61F002/00

US Classification:

424/426000

Abstract:

Flowable polymeric microparticulate surgical adhesive formulations are provided which can be activated at the site of the repair to produce cohesive material with tissue bonding properties to adjacent tissues. The formulation may be activated at the site of repair by mechanical shear forces, heat, ultrasound, UV, or other site.

US Patent:

20010012522, Aug 9, 2001

Filed:

Jan 11, 2001

Appl. No.:

09/758988

Inventors:

Thomas Ottoboni - Belmont CA, US
Robert Short - Los Gatos CA, US
Ronald Yamamoto - San Francisco CA, US

International Classification:

A61K009/50

US Classification:

424/501000

Abstract:

Microparticles are provided comprising a shell of an outer layer of a biologically compatible material and an inner layer of biodegradable polymer. The core of the microparticles contain a gas, liquid or solid for use in drug delivery or as a contrast agent for ultrasonic contrast imaging. The microparticles are capable of passing through the capillary systems of a subject.

US Patent:

20040086459, May 6, 2004

Filed:

Oct 20, 2003

Appl. No.:

10/690045

Inventors:

Thomas Ottoboni - Belmont CA, US
Robert Short - Los Gatos CA, US
Ronald Yamamoto - San Francisco CA, US

International Classification:

A61K049/00

US Classification:

424/009520

Abstract:

Microparticles are provided comprising a shell of an outer layer of a biologically compatible material and an inner layer of biodegradable polymer. The core of the microparticles contain a gas, liquid or solid for use in drug delivery or as a contrast agent for ultrasonic contrast imaging. The microparticles are capable of passing through the capillary systems of a subject.

US Patent:

20050013780, Jan 20, 2005

Filed:

Aug 17, 2004

Appl. No.:

10/921025

Inventors:

Thomas Otoboni - Belmont CA, US
E. Tickner - Watsonville CA, US
Robert Short - Los Gatos CA, US
Ronald Yamamoto - San Francisco CA, US

International Classification:

A61K049/00

US Classification:

424009520

Abstract:

A composition for ultrasonic imaging is described having a microparticle population of controlled fragility. A method of using such composition for imaging a fluid filled cavity, vessel or tissue is described.