Robert Scott Siegel

US Patent:

6689086, Feb 10, 2004

Filed:

Jul 29, 1999

Appl. No.:

09/363778

Inventors:

Henry Nita - Mission Viejo CA
Timothy Mills - Belvedere Tiburon CA
Robert Siegel - Venice CA

Assignee:

Advanced Cardiovascular Systems, Inc. - Santa Clara CA

International Classification:

A61B 1720

US Classification:

604 22, 604500, 604508, 606128, 606169, 601 2

Abstract:

An ultrasound delivery catheter equipped and configured for concurrent delivery of drugs or therapeutic agents. The catheter comprises an elongate pliable catheter body having an ultrasound delivery member or wire extending longitudinally therethrough. A drug/therapeutic agent infusion lumen also extends longitudinally through the body of the catheter and opens distally through one or more outflow apertures at or near the distal end of the catheter body. The drug/therapeutic agent outflow apertures are preferably positioned and configured to cause the drug or therapeutic agent to flow in direction(s) non-parallel to the longitudinal axis of the catheter. The delivery of ultrasound through the catheter, concurrent with infusion of drug or therapeutic agent therethrough, will cause the drug or therapeutic agent to be disseminated or dispersed by the ultrasonic vibration or movement at the distal end of the catheter.

US Patent:

54745306, Dec 12, 1995

Filed:

Jun 8, 1994

Appl. No.:

8/255513

Inventors:

James D. Passafaro - Santa Ana CA
Henry Nita - Lake Forest CA
Robert J. Siegel - Venice CA
Douglas H. Gesswein - Mission Viejo CA

Assignee:

Baxter International Inc. - Deerfield IL

International Classification:

A61B 1720

US Classification:

604 22

Abstract:

A catheter device incorporating combined ultrasound ablation and balloon dilation components. The catheter device generally comprises an elongate catheter body having proximal and distal ends and an outer surface. Disposed on the outer surface of the catheter body is a dilation balloon. At least one balloon inflation lumen fluidly connects the proximal end of the catheter body to the dilation balloon to permit injection of inflation fluid into the dilation balloon. Extending longitudinally through the catheter body is an ultrasound transmission member having a proximal end and a distal end, with the proximal end being connectable to an ultrasound transducer such that ultrasonic energy will pass through the ultrasound transmission member to the distal end thereof. In alternative embodiments of the present invention, there are provided catheter devices incorporating combined ultrasound ablation and laser ablation components as well as combined ultrasound ablation and atherectomy ablation components.

US Patent:

53973011, Mar 14, 1995

Filed:

Jul 19, 1993

Appl. No.:

8/094416

Inventors:

Russell Pflueger - Newport Beach CA
Henry Nita - Lake Forest CA
Steven Bacich - Laguna Niguel CA
Robert Siegel - Venice CA
Geoffrey Bond - Lakewood NY
Eugene DeCastro - Jamestown NY

Assignee:

Baxter International Inc. - Deerfield IL

International Classification:

A61B 1720
A61B 1732

US Classification:

604 22

Abstract:

An ultrasonic angioplasty device comprising an elongate ultrasound transmission member having a proximal end attachable to an ultrasound generating device and a bulbous distal head or probe formed on the distal end thereof for effecting ablative treatment of an occluding lesion. The ultrasound transmission member may be formed of one or more superelastic metal alloys such as NiTi (50 at. % Ni). A guidewire lumen may be formed in the distal head or probe to permit passage of a guidewire therethrough. Portions of the ultrasound transmission member may be curved or bent. Portions of the ultrasound transmission member may be tapered or narrowed. One or more surface disruptions may be formed on the distal head or probe to improve treatment efficacy. An increased hardness coating or outer skin may be formed on the ultrasound transmission member. The device of the present invention may be incorporated into an angioscopic device.

US Patent:

59974974, Dec 7, 1999

Filed:

Jun 18, 1997

Appl. No.:

8/878463

Inventors:

Henry Nita - Mission Viejo CA
Timothy Mills - Belvedere Tiburon CA
Robert Siegel - Venice CA

Assignee:

Advanced Cardiovascular Systems - Santa Clara CA

International Classification:

A61B 1770

US Classification:

604 22

Abstract:

An ultrasound delivery catheter equipped and configured for concurrent delivery of drugs or therapeutic agents. The catheter comprises an elongate pliable catheter body having an ultrasound delivery member or wire extending longitudinally therethrough. A drug/therapeutic agent infusion lumen also extends longitudinally through the body of the catheter and opens distally through one or more outflow apertures at or near the distal end of the catheter body. The drug/therapeutic agent outflow apertures are preferably positioned and configured to cause the drug or therapeutic agent to flow in direction(s) non-parallel to the longitudinal axis of the catheter. The delivery of ultrasound through the catheter, concurrent with infusion of drug or therapeutic agent therethrough, will cause the drug or therapeutic agent to be disseminated or dispersed by the ultrasonic vibration or movement at the distal end of the catheter.

US Patent:

53242556, Jun 28, 1994

Filed:

Jul 10, 1992

Appl. No.:

7/911651

Inventors:

James D. Passafaro - Santa Ana CA
Henry Nita - Lake Forest CA
Robert J. Siegel - Venice CA
Douglas H. Gesswein - Mission Viejo CA

Assignee:

Baxter International Inc. - Deerfield IL

International Classification:

A61B 1720

US Classification:

604 22

Abstract:

A catheter device incorporating combined ultrasound ablation and balloon dilation components. The catheter device generally comprises an elongate catheter body having proximal and distal ends and an outer surface. Disposed on the outer surface of the catheter body is a dilation balloon. At least one balloon inflation lumen fluidly connects the proximal end of the catheter body to the dilation balloon to permit injection of inflation fluid into the dilation balloon. Extending longitudinally through the catheter body is an ultrasound transmission member having a proximal end and a distal end, with the proximal end being connectable to an ultrasound transducer such that ultrasonic energy will pass through the ultrasound transmission member to the distal end thereof. In alternative embodiments of the present invention, there are provided catheter devices incorporating combined ultrasound ablation and laser ablation components as well as combined ultrasound ablation and atherectomy ablation components.

US Patent:

55406564, Jul 30, 1996

Filed:

Jan 24, 1995

Appl. No.:

8/378047

Inventors:

Russell Pflueger - Newport Beach CA
Henry Nita - Lake Forest CA
Steven Bacich - Laguna Niguel CA
Robert Siegel - Venice CA
Geoffrey Bond - Lakewood NY
Eugene DeCastro - Jamestown NY

Assignee:

Baxter International, Inc. - Irvine CA

International Classification:

A61B 1720

US Classification:

604 22

Abstract:

An ultrasonic angioplasty device comprising an elongate ultrasound transmission member having a proximal end attachable to an ultrasound generating device and a bulbous distal head or probe formed on the distal end thereof for effecting ablative treatment of an occluding lesion. The ultrasound transmission member may be formed of one or more superelastic metal alloys such as NiTi (50 at. % Ni). A guidewire lumen may be formed in the distal head or probe to permit passage of a guidewire therethrough. Portions of the ultrasound transmission member may be curved or bent. Portions of the ultrasound transmission member may be tapered or narrowed. One or more surface disruptions may be formed on the distal head or probe to improve treatment efficacy. An increased hardness coating or outer skin may be formed on the ultrasound transmission member. The device of the present invention may be incorporated into an angioscopic device.

US Patent:

53041151, Apr 19, 1994

Filed:

Jan 11, 1991

Appl. No.:

7/640190

Inventors:

Henry Nita - Lake Forest CA
Steven Bacich - Laguna Niguel CA
Robert Siegel - Venice CA
Geoffrey Bond - Lakewood NY
Eugene DeCastro - Jamestown NY

Assignee:

Baxter International Inc. - Deerfield IL
SonicStar International, Ltd. - Jamestown NY

International Classification:

A61B 1770

US Classification:

604 22

Abstract:

An ultrasonic angioplasty device comprising an elongate ultrasound transmission member having a proximal end attachable to an ultrasound generating device and a bulbous distal head or probe formed on the distal end thereof for effecting ablative treatment of an occluding lesion. The ultrasound transmission member may be formed of one or more superelastic metal alloys such as NiTi (50 at. % Ni). A guidewire lumen may be formed in the distal head or probe to permit passage of a guidewire therethrough. Portions of the ultrasound transmission member may be curved or bent. Portions of the ultrasound transmission member may be tapered or narrowed. One or more surface disruptions may be formed on the distal head or probe to improve treatment efficacy. An increased hardness coating or outer skin may be formed on the ultrasound transmission member. The device of the present invention may be incorporated into an angioscopic device.