Robert L Simmons

US Patent:

20100144730, Jun 10, 2010

Filed:

Jul 2, 2007

Appl. No.:

12/307104

Inventors:

Kenneth Egnard Lind - Arlington MA, US
Kathy Cao - Sunnyvale CA, US
Edward Yin-shiang Lin - Chestnut Hill MA, US
Thinh Ba Nguyen - Santa Clara CA, US
Bradley T. Tangonan - San Francisco CA, US
Daniel A. Erlanson - San Francisco CA, US
Kevin Guckian - Marlborough MA, US
Robert Lowell Simmons - San Francisco CA, US
Lihong Sun - Lexington MA, US
Stig Hansen - Kensington CA, US
Nuzhat Pathan - San Diego CA, US
Lei Zhang - Cheshire CT, US

Assignee:

Sunesis Phamaceuticals - South San Francisco CA
Biogen IDEC,INC - Cambrige MA

International Classification:

A61K 31/437
C07D 471/04
C07D 487/04
C07D 413/14
A61K 31/519
A61K 31/5377
A61P 35/00

US Classification:

5142345, 546113, 546119, 544262, 544127, 514300, 514303, 5142621

Abstract:

The present invention provides pyridinonyl PDK1 inhibitors and methods of treating cancer using the same.

US Patent:

52617890, Nov 16, 1993

Filed:

Aug 25, 1992

Appl. No.:

7/935065

Inventors:

Don Butts - Swampscott MA
John G. Nourse - Gansevoort NY
Robert C. Simmons - Springdale OH

Assignee:

General Electric Company - Cincinnati OH

International Classification:

F01D 518

US Classification:

416 96R

Abstract:

A gas turbine engine blade includes an airfoil having first and second sides and a dovetail extending from the airfoil root. The airfoil includes a tip having a tip floor with first and second tip walls extending from the floor and spaced apart to define therebetween a tip pienum. The first tip wall is recessed at least in part from the airfoil first side to define an outwardly facing tip shelf, with the tip shelf and the first tip wall defining therebetween a trough. A plurality of cooling holes extend through the tip floor at the tip shelf for channeling cooling air from a flow channel inside the airfoil into the trough for cooling the blade tip.

US Patent:

20180370966, Dec 27, 2018

Filed:

Jan 22, 2018

Appl. No.:

15/876462

Inventors:

- South San Francisco CA, US
- Cambridge MA, US
Edward Yin-shiang LIN - Chestnut Hill MA, US
Thinh Ba NGUYEN - Santa Clara CA, US
Bradley T. TANGONAN - San Francisco CA, US
Daniel A. ERLANSON - San Francisco CA, US
Kevin GUCKIAN - Marlborough MA, US
Robert Lowell SIMMONS - San Francisco CA, US
Wen-cherng LEE - Lexington MA, US
Lihong SUN - Lexington MA, US
Stig HANSEN - Kensington CA, US
Nuzhat PATHAN - San Diego CA, US
Lei ZHANG - Cheshire CT, US

International Classification:

C07D 471/04
C07D 409/12
A61K 31/4985
C07D 405/12
C07D 405/14
C07D 417/14
C07D 487/04
C07D 417/12
C07D 413/14
C07D 413/12
C07D 409/14
C07D 407/14
C07D 401/14
C07D 401/12
C07D 213/64
A61K 31/506
A61K 31/519
A61K 31/5377
A61K 31/4412
A61K 31/443
A61K 31/4436
A61K 31/4439
A61K 31/444
C07D 211/86

Abstract:

The present invention provides pyridinonyl PDK1 inhibitors and methods of treating cancer using the same.

US Patent:

20150018351, Jan 15, 2015

Filed:

Jul 10, 2014

Appl. No.:

14/328256

Inventors:

- South San Franciso CA, US
- Cambridge MA, US
Edward Yin-shiang Lin - Chestnut Hill MA, US
Thinh Ba Nguyen - Santa Clara CA, US
Bradley T. Tangonan - San Francisco CA, US
Daniel A. Erlanson - San Francisco CA, US
Kevin Guckian - Marlborough MA, US
Robert Lowell Simmons - San Francisco CA, US
Wen-cherng Lee - Lexington MA, US
Lihong Sun - Lexington MA, US
Stig Hansen - Kensington CA, US
Nuzhat Pathan - San Diego CA, US
Lei Zhang - Cheshire CT, US

International Classification:

C07D 471/04
C07D 409/14
C07D 401/12
C07D 487/04

US Classification:

5142345, 514300, 435375, 514303, 5142621, 514249, 514339, 51426621, 514272, 514338

Abstract:

The present invention provides pyridinonyl PDK1 inhibitors and methods of treating cancer using the same.