Robert L Sims

US Patent:

51643987, Nov 17, 1992

Filed:

Apr 1, 1991

Appl. No.:

7/678772

Inventors:

Robert T. Sims - Holicong PA
William Slivka - Philadelphia PA

Assignee:

Merck & Co., Inc. - Rahway NJ
McNeil-PPC, Inc. - Fort Washington PA

International Classification:

A61K 3119
A61K 3144

US Classification:

514282

Abstract:

This invention relates to pharmaceutical compositions for use in the treatment of pain and inflammation and the relief of cough and cold symptoms in a mammalian organism, said composition comprising: (i) an analgesically and anti-inflammatory effective amount of (S)-ibuprofen, or a salt thereof, substantially free of (R)-ibuprofen; and (ii) an antitussively effective amount of at least one antitussive agent selected from codeine, hydrocodone, caramiphen, carbetapentane, or dextromethorphan, or a therapeutically active stereoisomer thereof substantially free of its other stereoisomers and optionally iii) a therapeutically effective amount of at least one expectorant selected from guaicolsulfonate, guaifenesin, guaiacol, or terpin; or a pharamceutically acceptable salt thereof.

US Patent:

52885070, Feb 22, 1994

Filed:

Jul 29, 1992

Appl. No.:

7/921879

Inventors:

Robert T. Sims - Holicong PA
Thomas N. Gates - Doylestown PA
William Slivka - Philadelphia PA

Assignee:

Merck & Co., Inc. - Rahway NJ
McNeill-PPC, Inc. - Fort Washington PA

International Classification:

A61K 3306
A61K 3308
A61K 3310

US Classification:

424682

Abstract:

This invention relates to a pharmaceutical composition for use in the treatment of pain and inflammation and the treatment of acid indigestion, sour stomach, heartburn and symptoms of upset stomach associated with these conditions in a mammalian organism, said composition comprising: (i) an analgesically and anti-inflammatory effective amount of (S)-ibuprofen, or a salt thereof, substantially free of (R)-ibuprofen; (ii) an amount effective in the treatment of acid indigestion, sour stomach and/or heartburn of at least one of the antacids; and (iii) optionally, an amount effective in treating excess gas and flatulence of an anti-gas agent.

US Patent:

52603377, Nov 9, 1993

Filed:

Jul 29, 1992

Appl. No.:

7/921882

Inventors:

Robert T. Sims - Holicong PA
Thomas N. Gates - Doylestown PA
William Slivka - Philadelphia PA

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

A61K 3119
A61K 31135

US Classification:

514570

Abstract:

This invention relates to pharmaceutical compositions for use in the treatment of pain and inflammation and the treatment of muscle spasms and associated pain, soreness and tightness of muscles in mammalian organism, said composition comprising: (i) an analgesically and anti-inflammatory effective amount of (S)-ibuprofen, or a salt thereof, substantially free of (R)-ibuprofen; and (ii) an amount effective in the treatment of muscle spasms of at least one of the muscle relaxants, or a therapeutically active stereoisomer thereof, substantially free of its other stereoisomers.