Dr. Slaughter graduated from the University of Alabama School of Medicine in 1985. He works in Tuscaloosa, AL and specializes in Neurology. Dr. Slaughter is affiliated with DCH Regional Medical Center and Northport Medical Center.
Maria L. Garcia - Edison NJ Gloria C. Koo - Woodbridge NJ Reid J. Leonard - Westfield NJ Chiu-Chuan S. Lin - Holmdel NJ Robert S. Slaughter - Chatham NJ Scott P. Stevens - Westfield NJ Joanne M. Williamson - Cranford NJ
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
A61K 3817 C07K 14435
US Classification:
514 12
Abstract:
A thirty-nine amino acid peptide, Margatoxin (MgTX), is purified to homogeneity from venom of the scorpion Centruroides margaritatus. The gene encoding MgTX is constructed and this gene is expressed in E. coli, to produce recombinant MgTX. MgTX is a potent and selective inhibitor of a voltage-dependent K. sup. + channel present in human lymphocytes. MgTX exhibits immunosuppressant activity with human T-lymphocytes, and is useful as an immunosuppressant, in modeling nonpeptidyl K. sup. + channel blockers, and in establishing biochemical assays based on ligand binding or other protocols with which to screen for other novel modulators of voltage dependent K. sup. + channels in lymphocytes and other tissues including the brain. As an immunosuppressant, MgTX is useful in the treatment of autoimmune diseases, the prevention of rejection of foreign organ transplants and/or related afflictions, diseases and illnesses.
Name / Title
Company / Classification
Phones & Addresses
Robert J. Slaughter Director
Horace W Goldsmith Foundation Consumer Goods · Bus Services
Ronald Gordanier, Sharon Conrad, George Butch, Mildred Reece, Marie Sipe, Barbara Monasmith, Gordon Schaffer, Dick Kinsey, Lyla Ash, Margaret Stapleton, Richard E, Leta Snyder