Robert Ralston Snow

US Patent:

6465016, Oct 15, 2002

Filed:

Dec 29, 2000

Appl. No.:

09/750218

Inventors:

Indu Parikh - Durham NC
Robert A. Snow - West Chester PA

Assignee:

Research Triangle Pharmaceuticals - Durham NC

International Classification:

A61K 914

US Classification:

424489, 424486, 5147724

Abstract:

Pharmaceutical compositions containing solid cyclic oligopeptide cyclosporine microparticles are prepared by applying energy input to solid cyclic oligopeptide cyclosporine in the presence of phospholipid and one or more non-ionic, anionic or cationic second surface modifiers. The microparticles consist essentially of a solid cyclic oligopeptide cyclosporine core coated with a combination of phospholipid and at least one second surface modifier. The combination of phospholipid and second surface modifier(s) provide volume-weighted mean particle size values of solid cyclic oligopeptide cyclosporine particles that are about 50% smaller than cyclic oligopeptide cyclosporine particles produced in the presence of the phospholipid and without the presence of the second surface modifier(s) using the same energy input.

US Patent:

6534088, Mar 18, 2003

Filed:

Apr 20, 2001

Appl. No.:

09/838583

Inventors:

Pol-Henri W. Guivarch - Quebec, CA
Indu Parikh - Durham NC
Robert A. Snow - West Chester PA

Assignee:

SkyePharma Canada Inc. - Quebec

International Classification:

A61K 916

US Classification:

424470, 424469, 424489, 424439, 424455, 424484, 424502, 424824, 424464, 514543, 514460, 514687, 514721

Abstract:

This invention discloses an orally administered pharmaceutical composition for the treatment of elevated levels of cholesterol and related conditions comprising a statin and fenofibrate in the form of microparticles of solid fenofibrate that are stabilized by phospholipid as a surface active substance, wherein a therapeutically effective amount of the composition provides the statin and a quantity of fenofibrate to a fasted human patient that is greater than 80% of the quantity of fenofibrate provided by the same amount of the composition when administered to the same patient who has been fed a high fat meal.

US Patent:

20020058065, May 16, 2002

Filed:

Apr 20, 2001

Appl. No.:

09/838541

Inventors:

Pol-Henri Guivarc'h - Quebec, CA
Gary Pace - Raleigh NC, US
Robert Snow - West Chester PA, US
Awadesh Mishra - Quebec, CA

International Classification:

A61K009/48
A61K009/20
A61K031/216

US Classification:

424/465000, 424/452000, 514/543000

Abstract:

This invention discloses an orally administered pharmaceutical composition comprising microparticles of solid fenofibrate that are stabilized by a phospholipid surface active substance that is present during the preparation of the microparticles, wherein a therapeutically effective amount of the composition provides a quantity of fenofibrate active species to a fasted human patient in need of treatment by fenofibrate that is greater than 80% of the quantity of fenofibrate active species provided by the same amount of the composition when administered to the same patient who has been fed a high fat meal consisting of at least 1000 calories, 50% of which are from fat. The present invention also provides a method of treatment of dislipidemia and dislipoproteinemia in a mammal consisting of administering a therapeutically effective oral dosage form comprising microparticles of a solid fibrate that are stabilized by a phospholipid surface active substance wherein the dosage form provides into the blood of the patient in a fasted state a therapeutically effective amount of a fibrate active species that is at least 90% of the AUC amount of the fibrate active species provided by the same dosage form into the blood of the same patient when the patient is in a fed state.

US Patent:

20040086571, May 6, 2004

Filed:

Mar 17, 2003

Appl. No.:

10/388597

Inventors:

Pol-Henri Guivarc'h - Quebec, CA
Indu Parikh - Durham NC, US
Robert Snow - West Chester PA, US

Assignee:

SKYEPHARMA CANADA INC. - VERDUN

International Classification:

A61K031/401
A61K031/366
A61K031/225
A61K031/192

US Classification:

424/489000, 514/423000, 514/460000, 514/571000, 514/548000

Abstract:

This invention discloses an orally administered pharmaceutical composition for the treatment of elevated levels of cholesterol and related conditions comprising a statin and fenofibrate in the form of microparticles of solid fenofibrate that are stabilized by phospholipid as a surface active substance, wherein a therapeutically effective amount of the composition provides the statin and a quantity of fenofibrate to a fasted human patient that is greater than 80% of the quantity of fenofibrate provided by the same amount of the composition when administered to the same patient who has been fed a high fat meal.

US Patent:

41157788, Sep 19, 1978

Filed:

Nov 18, 1976

Appl. No.:

5/742680

Inventors:

Robert Eric Snow - Raleigh NC

Assignee:

JFD Electronics Corporation - Oxford NC

International Classification:

H01Q 126

US Classification:

343701

Abstract:

A miniature antenna which is rugged, extremely light-weight and which is especially adapted for reception across the entire FM band comprising an omnidirectional half-wave dipole having feed structure comprised of curved overlapping dipole element points connected to a solid state amplifier having staggered tuned input and output circuits. The input to the amplifier is maintained essentially balanced to preserve the omnidirectional pattern of the dipole. The physical location of the solid state amplifier is such that it is directly connected to the feed point of the dipole eliminating transmission line losses. The coaxial cable is employed in a diplexed manner for connecting the DC power supply to the solid state amplifier and for connecting the amplified output signal to an impedance converter which is to provide proper impedance match for the antenna input signals of an FM tuner/receiver. The design provides an omnidirectional E-plane pattern and the staggered tuned amplifier provides adequate gain across bandwidth sufficient to cover the FM band.

Address:

1103 Beechtree Ct, Hartsville, SC 29550

VIN:

5NPET4AC3AH618642

Make:

HYUNDAI

Model:

SONATA

Year:

2010