Robert Phillip Stern

US Patent:

6575888, Jun 10, 2003

Filed:

Jan 24, 2001

Appl. No.:

09/769194

Inventors:

Paul O. Zamora - Gaithersburg MD
Robert A. Stern - Boxford MA

Assignee:

BioSurface Engineering Technologies, Inc. - College Park MD

International Classification:

A61N 500

US Classification:

600 3

Abstract:

A bioabsorbable brachytherapy device includes a tubular housing with sealed ends and an enclosed radioactive material. The radioactive material includes a radioisotope, such as palladium-103 or iodine-125. The tubular housing is made from a biocompatible and bioabsorbable polymeric material, and is sealed by means such as heat welding or solvent fixing. The device may further include a radiopaque medium and one or more therapeutic drugs.

US Patent:

6731927, May 4, 2004

Filed:

Sep 22, 2000

Appl. No.:

09/668591

Inventors:

Robert Allen Stern - Los Altos CA
Rod Drury - Wellington, NZ
Sunny Ahn - Cambridge MA

Assignee:

Context Connect, Inc. - Boxford MA

International Classification:

H04M 342

US Classification:

4554141, 455411, 707 9, 37921801

Abstract:

The present invention relates generally to an information system, and more particularly to a system and method for providing access to an entity by context association.

US Patent:

7105330, Sep 12, 2006

Filed:

Jul 18, 2003

Appl. No.:

10/622283

Inventors:

Robert Stern - San Francisco CA, US
Gregory I. Frost - San Francisco CA, US
Anthony Csoka - San Francisco CA, US
Tim M. Wong - San Francisco CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

G01N 33/53
G01N 33/537
G01N 33/543
C12N 5/06
C07K 16/40

US Classification:

435200, 435201, 435207, 435 696, 435 792, 435 18, 4353201, 435338, 424 9462, 424 9461, 53038826

Abstract:

The invention is based on the discovery of methods for purification of an acid active hyaluronidase found in human plasma (hpHAse), including both biochemical and immunoaffinity purification methods. The method of immunoaffinity purification of the invention is based on the discovery of a method for identifying antibodies that specifically bind native hpHAse (anti-native hpHAse antibodies), and anti-native hpHAse antibodies identified by this screening method. The invention also features an assay for sensitive detection of HAse activity using biotinylated hyaluronic acid (bHA). Purification and characterization of hpHAse lead to the inventors' additional discovery that hpHAse is encoded by the LuCa-1 gene, which gene is present in the human chromosome at 3p21. 3, a region associated with tumor suppression. The invention additionally features methods of treating tumor-bearing patients by administration of hpHAse and/or transformation of cells with hpHAse-encoding DNA.

US Patent:

7148201, Dec 12, 2006

Filed:

Feb 27, 2001

Appl. No.:

09/795914

Inventors:

Robert Stern - San Francisco CA, US
Gregory I. Frost - San Francisco CA, US
Anthony Csóka - San Francisco CA, US
Tim M. Wong - San Francisco CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A61K 31/70
A01N 63/00
C12N 15/63
A61K 38/43
G01N 33/53

US Classification:

514 44, 4353201, 435455, 424 932

Abstract:

The invention is based on the discovery of methods for purification of an acid active hyaluronidase found in human plasma (hpHAse), including both biochemical and immunoaffinity purification methods. The method of immunoaffinity purification of the invention is based on the discovery of a method for identifying antibodies that specifically bind native hpHAse (anti-native hpHAse antibodies), and anti-native hpHAse antibodies identified by this screening method. The invention also features an assay for sensitive detection of HAse activity using biotinylated hyaluronic acid (bHA). Purification and characterization of hpHAse lead to the inventors' additional discovery that hpHAse is encoded by the LuCa-1 gene, which gene is present in the human chromosome at 3p21. 3, a region associated with tumor suppression. The invention additionally features methods of treating tumor-bearing patients by administration of hpHAse and/or transformation of cells with hpHAse-encoding DNA.

US Patent:

7539656, May 26, 2009

Filed:

Mar 6, 2001

Appl. No.:

09/798964

Inventors:

Raya Fratkina - Hayward CA, US
Monica Anderson - San Jose CA, US
Mark A. Angel - Cupertino CA, US
Max Copperman - Santa Cruz CA, US
Scott B. Huffman - Redwood City CA, US
David Kay - Los Gatos CA, US
Robert Stern - Cupertino CA, US

Assignee:

Consona CRM Inc. - Indianapolis IN

International Classification:

G06F 17/00
G06F 17/30
G06N 5/00

US Classification:

706 45, 707 3, 7071041

Abstract:

A method and system are disclosed for retrieving information through the use of a multi-stage interaction with a client to identify particular knowledge content associated with a knowledge map. The present invention is an application program running on a server accessed via the world-wide web or other data network using standard Internet protocols, a web browser and web server software. In addition to an automated portion, the present invention allows a human dialog designer to model the way the system elicits information, giving a human feel to the dialog and a better customer experience. In operation, users start a dialog by directing their web browser to a designated web page. This web page asks the user some initial questions that are then passed to a dialog engine. The dialog engine then applies its methods and algorithms to a knowledge map, using dialog control information\ and the user's responses to provide feedback to the user. The feedback may include follow-up questions, relevant documents, and instructions to the user (e. g.

US Patent:

7781397, Aug 24, 2010

Filed:

Oct 3, 2006

Appl. No.:

11/538246

Inventors:

Robert Stern - San Francisco CA, US
Gregory I. Frost - San Francisco CA, US
Anthony Csoka - San Francisco CA, US
Tim M. Wong - San Francisco CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A01N 37/18

US Classification:

514 2, 514 8

Abstract:

The invention is based on the discovery of methods for purification of an acid active hyaluronidase found in human plasma (hpHAse), including both biochemical and immunoaffinity purification methods. The method of immunoaffinity purification of the invention is based on the discovery of a method for identifying antibodies that specifically bind native hpHAse (anti-native hpHAse antibodies), and anti-native hpHAse antibodies identified by this screening method. The invention also features an assay for sensitive detection of HAse activity using biotinylated hyaluronic acid (bHA). Purification and characterization of hpHAse lead to the inventors' additional discovery that hpHAse is encoded by the LuCa-1 gene, which gene is present in the human chromosome at 3p21. 3, a region associated with tumor suppression. The invention additionally features methods of treating tumor-bearing patients by administration of hpHAse and/or transformation of cells with hpHAse-encoding DNA.

US Patent:

20020055667, May 9, 2002

Filed:

Apr 27, 2001

Appl. No.:

09/845035

Inventors:

William Mavity - Los Altos CA, US
Robert Stern - Mountain View CA, US
Shigemasa Osaki - Sandy UT, US
Paul Zamora - Gaithersburg MD, US

International Classification:

A61N005/00

US Classification:

600/003000

Abstract:

Combination radiation delivery and chemotherapy devices comprise bioabsorbable structures with radionuclides and chemotherapeutic agents immobilized on said structures. The bioabsorbable structures have a predefined persistence period which is usually substantially greater than the half-life of the radionuclides, thus assuring that the radionuclides remain localized and sequestered at a desired target site while significant radioactivity remains. The radiation delivery and chemotherapy devices are suitable for a wide variety of medical purposes, being particularly suitable for the treatment of solid tumors by injection or open surgical introduction of the devices at a target site. Kits comprising the devices together with instructions for use are also provided.

US Patent:

20130346124, Dec 26, 2013

Filed:

Jun 19, 2013

Appl. No.:

13/921773

Inventors:

Robert A. Stern - Los Altos CA, US
Roxanne Stern - Los Altos CA, US
Kathryn Stern - Los Altos CA, US
Andrew C. Stern - Los Altos CA, US

International Classification:

G06Q 10/02

US Classification:

705 6

Abstract:

A method and system are provided for determining a group travel destination and compatible travel itinerary for a travel party to travel on a trip together. A unique identifier is created or used by each individual traveler, and each individual traveler is asked a series of hierarchical questions concerning parameters for travel in order to create a profile. Multiple traveler profiles are linked to form a set of travel party data. After further refining and polling a common destination and a common set of travel dates is selected from possible travel dates after a lookup by the system in each travelers individual calendars.