Robert J Tinder

US Patent:

20090093630, Apr 9, 2009

Filed:

Sep 19, 2008

Appl. No.:

12/234033

Inventors:

Sreenivasulu Megati - New City NY, US
Shilpa Bhansali - Wynnewood PA, US
Christoph Dehnhardt - New York NY, US
Subodh Deshmukh - White Plains NY, US
Peter Fung - Northport NY, US
Michael MacEwan - Monroe NY, US
Robert J. Tinder - New City NY, US

Assignee:

Wyeth - Madison NJ

International Classification:

C07D 487/22

US Classification:

540579

Abstract:

The present invention relates to improved methods of resolution and recrystallization for synthesizing compounds useful as 5HTagonists or partial agonists, including intermediates thereto.

US Patent:

6750344, Jun 15, 2004

Filed:

Sep 5, 1997

Appl. No.:

08/924851

Inventors:

Eric Edward Swayze - Carlsbad CA
Peter William Davis - Encinitas CA
Robert Jay Tinder - La Jolla CA
Kelly G. Sprankle - Vista CA

Assignee:

ISIS Pharmaceuticals, Inc. - Carlsbad CA

International Classification:

C07D24136

US Classification:

544355, 544338, 544336, 544349, 435 4, 435 71, 436501, 436518, 436536

Abstract:

The present invention provides monocyclic, bicyclic and oligomeric amine compounds with at least two sites of diversity. These compounds are formed from monocyclic scaffolds which can be cyclized to form bicyclic amine scaffolds. These can then be reacted with building blocks to form the amine compounds of the invention. This invention further provides libraries or monocyclic, bicyclic and oligomeric amine compounds. Also provided are methods for preparing monocyclic, bicyclic and oligomeric amine compounds and libraries thereof. The present invention also provides pharmaceutical compositions of the monocyclic, bicyclic and oligomeric amine compounds.