Robert G Webster

US Patent:

7850956, Dec 14, 2010

Filed:

Jan 22, 2004

Appl. No.:

10/763049

Inventors:

Harriet L. Robinson - Atlanta GA, US
Ellen F. Fynan - Sterling MA, US
Robert G. Webster - Memphis TN, US
Shan Lu - Franklin MA, US

Assignee:

University of Massachusetts Medical Center - Worcester MA
St. Jude Children's Research Hospital - Memphis TN

International Classification:

A61K 48/00
A61K 39/12

US Classification:

424 932, 514 44, 4241861

Abstract:

This invention relates to a method of immunizing a vertebrate, comprising introducing into the vertebrate a DNA transcription unit which comprises DNA encoding a desired antigen or antigens. The uptake of the DNA transcription unit by a host vertebrate results in the expression of the desired antigen or antigens, thereby eliciting humoral or cell-mediated immune responses or both humoral and cell-mediated responses. The elicited humoral and cell-mediated immune response can provide protection against infection by pathogenic agents, provide an anti-tumor response, or provide contraception. The host can be any vertebrate, avian or mammal, including humans.

US Patent:

20080004597, Jan 3, 2008

Filed:

Apr 6, 2007

Appl. No.:

11/784385

Inventors:

Omar Lattouf - Atlanta GA, US
Robert Webster - Orlando FL, US
Sarah Webster - Orlando FL, US
Sameer Shums - Lilbuen GA, US
Carribeth Ramey - Suwanee GA, US
Amin Rahme - Atlanta GA, US

International Classification:

A61M 31/00

US Classification:

604511000, 604101050, 604174000

Abstract:

Methods and devices for performing endocardiac treatments using an instrument port placed in the heart wall and an instrument guide which has a steerable tip and which is inserted through the instrument port, allows passage of an instrument therethrough into a heart chamber, and steers the functional tip of the instrument to the desired location for treatment.

US Patent:

20140030702, Jan 30, 2014

Filed:

Oct 3, 2013

Appl. No.:

14/045097

Inventors:

Aleksandr S. Lipatov - Atlanta GA, US
Richard J. Webby - Memphis TN, US
Elena A. Govorkova - Cordova TN, US
Robert G. Webster - Memphis TN, US

Assignee:

St. Jude Children's Research Hospital - Memphis TN

International Classification:

C12Q 1/02
C07K 14/005

US Classification:

435 5, 536 2372, 530396, 4352351

Abstract:

The immunogenicity of the influenza virus hemagglutinin (HA) molecule may be increased by substitutions of amino acids in the HA sequence. The substitution of specific HA residues, such as asparagine at position 223 of H5 HA, increase the sensitivity of the hemagglutinin inhibition (HI) assay by altering receptor specificity and/or antibody-antigen binding. HA molecules containing such substitutions will be useful in the development of diagnostic reference viruses and improved influenza vaccines.

US Patent:

52464490, Sep 21, 1993

Filed:

Mar 20, 1992

Appl. No.:

7/854211

Inventors:

Robert M. Webster - Fairburn GA

International Classification:

A45D 2600

US Classification:

606131

Abstract:

A first embodiment of a novel parasite remover has a holding plate and an engagement plate for attachment to pivoting arms of a staple remover. The holding plate has a slot for insertion between a parasite body and the skin of a host to which the parasite has attached itself. The engagement plate has a pair of curved prongs spaced apart to define a slot therebetween for straddling the parasite mouth which is inserted into the host skin. As the pivoting arms of the staple remover are moved together, the curved prongs engage the parasite body and extract the parasite from the host skin. A second embodiment has a handle arm and a lever arm which are pivotally mounted together. As a result, the lever arm has a prying end pivotal with respect to a trigger end. The handle arm engages and lifts a parasite away from the host skin. On the lever arm, the prying end presses the host skin in a direction substantially normal to the host skin upon application of user force at the trigger end.

US Patent:

45527580, Nov 12, 1985

Filed:

Dec 20, 1983

Appl. No.:

6/563372

Inventors:

Brian R. Murphy - Bethesda MD
Robert M. Chanock - Bethesda MD
Robert G. Webster - Memphis TN
Virginia S. Hinshaw - Germantown TN

Assignee:

St. Jude Children's Research Hospital - Memphis TN

International Classification:

A61K 39145

US Classification:

424 89

Abstract:

A method of producing a live attenuated vaccine useful in humans which comprises producing an influenza A reassortant virus by gene exchange between an avian influenza virus parent and a human influenza virus parent and then excluding the internal genes (that code for non-surface viral proteins) of the human influenza virus parent from the reassortant by temperature selection and excluding the surface antigen genes of the avian influenza A virus parent by antibodies.

US Patent:

53803396, Jan 10, 1995

Filed:

Sep 17, 1993

Appl. No.:

8/123135

Inventors:

Robert M. Webster - Fairburn GA

International Classification:

A45D 2600

US Classification:

606131

Abstract:

A first embodiment of a novel parasite remover has a holding plate and an engagement plate for attachment to pivoting arms of a staple remover. The holding plate has a slot for insertion between a parasite body and the skin of a host to which the parasite has attached itself. The engagement plate has a pair of curved prongs spaced apart to define a slot therebetween for straddling the parasite mouth which is inserted into the host skin. As the pivoting arms of the staple remover are moved together, the curved prongs engage the parasite body and extract the parasite from the host skin. A second embodiment has a handle arm and a lever arm which are pivotally mounted together. As a result, the lever arm has a prying end pivotal with respect to a trigger end. The handle arm engages and lifts a parasite away from the host skin. On the lever arm, the prying end presses the host skin in a direction substantially normal to the host skin upon application of user force at the trigger end.

US Patent:

45527571, Nov 12, 1985

Filed:

Dec 20, 1983

Appl. No.:

6/563370

Inventors:

Brian R. Murphy - Bethesda MD
Robert M. Chanock - Bethesda MD
Robert G. Webster - Memphis TN
Virginia S. Hinshaw - Germantown TN

Assignee:

St. Jude Children's Research Hospital - Memphis TN

International Classification:

A61K 39145

US Classification:

424 89

Abstract:

A method of producing a vaccine useful in animals which comprises producing a reassortment by gene exchange from an avian influenza A virus parent and an animal influenza A virus parent and then selecting for the reassortant containing two animal surface antigen genes and six avian internal genes by temperature and antibodies.