Robert O Weeks

US Patent:

43224067, Mar 30, 1982

Filed:

Dec 18, 1980

Appl. No.:

6/217962

Inventors:

Manuel Debono - Indianapolis IN
Kurt E. Merkel - Mooresville IN
Robert E. Weeks - Indianapolis IN
Herald J. Cole - Indianapolis IN

Assignee:

Eli Lilly and Company - Indianapolis IN

International Classification:

A61K 3500
A61K 716

US Classification:

424118

Abstract:

Antibiotic A-4696 factors B. sub. 1, B. sub. 2, B. sub. 3, C. sub. 1a, C. sub. 3, and E. sub. 1 are isolated from antibiotic A-4696, the latter being produced by Actinoplanes missouriensis strains ATCC 31680, ATCC 31682, and ATCC 31683 under submerged aerobic conditions in a culture medium and isolated from the fermentation broth by absorption on an ion exchange resin and eluted therefrom at p. sup. H 10. 5 with sodium hydroxide. The novel factors are separated by thin layer chromatography and high pressure liquid chromatography and have antimicrobial and growth promotant activity.

US Patent:

46379819, Jan 20, 1987

Filed:

Mar 26, 1984

Appl. No.:

6/593015

Inventors:

Charles L. Hershberger - New Palestine IN
Kurt E. Merkel - Mooresville IN
Robert E. Weeks - Indianapolis IN
Gene M. Wild - Indianapolis IN

Assignee:

Eli Lilly and Company - Indianapolis IN

International Classification:

C12P 1960
C12P 1956
C12N 120
C12R 1045

US Classification:

435 75

Abstract:

Glycopeptide antibiotic A-4696G is produced by culturing Actinoplanes missouriensis mutant strain ATCC 31681 under submerged aerobic fermentation conditions, and is recovered from the fermentation broth by resin adsorption and chromatographic purification. A-4696G inhibits the growth of bacteria pathogenic to man and animals and also enhances the growth of ruminants by increasing feed utilization.

US Patent:

44617232, Jul 24, 1984

Filed:

Sep 29, 1982

Appl. No.:

6/426493

Inventors:

Charles L. Hershberger - New Palestine IN
Kurt E. Merkel - Mooresville IN
Robert E. Weeks - Indianapolis IN
Gene M. Wild - Indianapolis IN

Assignee:

Eli Lilly and Company - Indianapolis IN

International Classification:

C07C10352

US Classification:

2601125R

Abstract:

Glycopeptide antibiotic A-4696G is produced by culturing Actinoplanes missouriensis mutant strain ATCC 31681 under submerged aerobic fermentation conditions, and is recovered from the fermentation broth by resin adsorption and chromatographic purification. A-4696G inhibits the growth of bacteria pathogenic to man and animals and also enhances the growth of ruminants by increasing feed utilization.

US Patent:

43755135, Mar 1, 1983

Filed:

Oct 9, 1981

Appl. No.:

6/309965

Inventors:

Manuel Debono - Indianapolis IN
Kurt E. Merkel - Mooresville IN
Robert E. Weeks - Indianapolis IN
Herald J. Cole - Indianapolis IN

Assignee:

Eli Lilly and Company - Indianapolis IN

International Classification:

C12P 106
C12R 1045

US Classification:

435169

Abstract:

Antibiotic A-4696 factors B. sub. 1, B. sub. 2, B. sub. 3, C. sub. 1a, C. sub. 3, and E. sub. 1 are isolated from antibiotic A-4696, the latter being produced by Actinoplanes missouriensis strains ATCC 31680, ATCC 31682, and ATCC 31683 under submerged aerobic conditions in a culture medium and isolated from the fermentation broth by absorption on an ion exchange resin and eluted therefrom at p. sup. H 10. 5 with sodium hydroxide. The novel factors are separated by thin layer chromatography and high pressure liquid chromatography and have antimicrobial and growth promotant activity.