Roberto R Rosato

US Patent:

20050004007, Jan 6, 2005

Filed:

Sep 7, 2001

Appl. No.:

10/363540

Inventors:

Steven Grant - Richmond VA, US
Paul Dent - Glen Allen VA, US
Roberto Rosato - Richmond VA, US
Leanne Cartee - Atlanta GA, US

International Classification:

A61K038/12
A61K031/353
A61K031/19

US Classification:

514007000, 514009000, 514167000, 514460000, 514456000, 514559000, 514575000

Abstract:

The invention provides compositions and methods for promoting apoptosis of cancer cells, and methods for treating cancer. The compositions comprise cyclin dependent kinase inhibitor and an agent that induces cellular differentiation. The methods of promoting apoptosis of cancer cells involve the co-administration to the cancer cells of a cyclin dependent kinase inhibitor and an agent that induces cell differentiation. The method for treating cancer involves the co-administration of a cyclin dependent kinase inhibitor and an agent that induces cellular differentiation to a patient. Examples of cyclin dependent kinase inhibitors include histone deacetylase inhibitors, protein kinase C activators, retinoids, and Vitamin D3.

Address:

12414 N Shadow Cv Ln, Houston, TX 77082

VIN:

2D8HN54P38R697935

Make:

DODGE

Model:

CARAVAN

Year:

2008