Robin C Clark

US Patent:

6376500, Apr 23, 2002

Filed:

Mar 8, 2001

Appl. No.:

09/803078

Inventors:

Robin Douglas Clark - Palo Alto CA
Counde OYang - Sunnyvale CA

Assignee:

Syntex (U.S.A.) LLC - Palo Alto CA

International Classification:

A01N 4354

US Classification:

514258, 514259, 544279, 544284, 544287

Abstract:

This invention relates to compounds which are generally alpha -receptor antagonists and which are represented by Formula I: wherein the substituents are as defined in the specification; or pharmaceutically acceptable salts, hydrates, or N-oxides thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their use as therapeutic agents, and a process for their preparation.

US Patent:

6551828, Apr 22, 2003

Filed:

Jun 28, 2000

Appl. No.:

09/606323

Inventors:

Robin Clark - Benicia CA

Assignee:

Protemation, Inc. - Bainbridge Island WA

International Classification:

C12N 1587

US Classification:

435462, 935 28, 435455, 435471, 435 731, 435 732, 435 721

Abstract:

Compositions, kits, and methods are provided for use in a recombinational cloning or subcloning methods for constructing expression vectors which comprise: ligating a library of double-stranded linear donor DNAs, where each member of the library includes a donor DNA sequence, with a double-stranded linear driver DNA which includes a promoter sequence and a donor recombination site to form a single circular donor DNA, the single circular donor DNA not including an origin of replication, where the donor DNA sequence is under the transcriptional control of the promoter; and contacting the circular donor DNA and a circular acceptor acceptor vector in the presence of a recombinase to form a single fused circular vector, the circular acceptor vector comprising an origin of replication and an acceptor recombination site capable of recombining with the circular donor DNA.

US Patent:

6787535, Sep 7, 2004

Filed:

Jun 6, 2002

Appl. No.:

10/164660

Inventors:

Colin Charles Beard - Palo Alto CA
Robin Douglas Clark - Palo Alto CA
Lawrence Emerson Fisher - Mountain View CA
David Bruce Repke - Milpitas CA
David George Putman - Saratoga CA

Assignee:

Syntex (U.S.A.) LLC - Palo Alto CA

International Classification:

A61K 3133

US Classification:

514183, 51425409, 514415, 544366, 544358, 544373, 548452, 548469, 548511, 548503

Abstract:

This invention relates to compounds which have generally 5-HT6 receptor affinity and which are represented by Formula I: wherein one of R , R or R is a group of general Formula B, wherein W is a âCHâ group or a nitrogen atom, and the other substituents are as defined herein; or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their use as therapeutic agents, and methods of preparation thereof.

US Patent:

20040248902, Dec 9, 2004

Filed:

Jun 25, 2004

Appl. No.:

10/876863

Inventors:

Colin Beard - Palo Alto CA, US
Robin Clark - Palo Alto CA, US
Lawrence Fisher - Mountain View CA, US
Ralph Harris - Redwood City CA, US
David Repke - Milpitas CA, US

International Classification:

A61K031/496
A61K031/405
C 07D 4 3/02

US Classification:

514/254090, 514/419000, 544/373000, 548/495000

Abstract:

This invention relates to compounds which have generally 5-HT6 receptor affinity and which are represented by Formula I: wherein one of R, Ror Ris a group of general Formula B, wherein W is a —CH— group or a nitrogen atom, and the other substituents are as defined herein; or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their use as therapeutic agents, and methods of preparation thereof.

US Patent:

20050171118, Aug 4, 2005

Filed:

Mar 3, 2005

Appl. No.:

11/071726

Inventors:

Colin Beard - Palo Alto CA, US
Robin Clark - Lawai HI, US
Lawrence Fisher - Mountain View CA, US
Ralph Harris - Redwood City CA, US
David Putman - Saratoga CA, US
David Repke - Milpitas CA, US

International Classification:

A61K031/496
A61K031/454
C07D043/02

US Classification:

514254090, 514323000, 546200000, 544373000

Abstract:

This invention relates to compounds which have generally 5-HT6 receptor affinity and which are represented by Formula I: wherein one of R, Ror Ris a group of general Formula B, wherein W is a —CH— group or a nitrogen atom, and the other substituents are as defined herein; or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their use as therapeutic agents, and methods of preparation thereof.

US Patent:

54461219, Aug 29, 1995

Filed:

Jan 17, 1995

Appl. No.:

8/373677

Inventors:

Robin D. Clark - Palo Alto CA
Lawrence E. Fisher - Mountain View CA
Lee A. Flippin - Woodside CA
Michael G. Martin - San Francisco CA
Stephen R. Stabler - Mountain View CA

Assignee:

Syntex (U.S.A.) Inc. - Palo Alto CA

International Classification:

C07D25702

US Classification:

548253

Abstract:

The present invention relates to processes for preparing 1-butyl-2-[2'-(2H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-indole-3-carboxyli c acid and to intermediates useful in such processes. The present invention also relates to a process for deprotecting compounds containing a protected 2H-tetrazolyl group, which process comprises reacting a the protected compound with a Lewis acid in the presence of a thiol.

US Patent:

46818898, Jul 21, 1987

Filed:

Jun 27, 1986

Appl. No.:

6/879689

Inventors:

Robin Clark - Palo Alto CA
Joseph M. Muchowski - Sunnyvale CA
Fang-Ting Chiu - Union City CA
John O. Gardner - Los Altos CA
Jacob Berger - Los Altos Hills CA

Assignee:

Syntex (U.S.A.) Inc. - Palo Alto CA

International Classification:

A61K 3147
C07D21720

US Classification:

514307

Abstract:

Compounds of the formula ##STR1## wherein R. sub. 1 and R. sub. 2 are each independently --H or lower alkoxy; R. sub. 3 and R. sub. 4 are each independently lower alkyl; and R. sub. 5 and R. sub. 6 are each --OCH. sub. 3, or together form --OCH. sub. 2 O-- or --OCH. sub. 2 CH. sub. 2 O-- and pharmaceutically acceptable acid addition salts thereof are calcium channel blockers useful for treating cardiovascular disorders including angina, hypertension and congestive heart failure.

US Patent:

49563653, Sep 11, 1990

Filed:

Oct 12, 1988

Appl. No.:

7/257372

Inventors:

Robin D. Clark - Palo Alto CA
Andrew T. Kilpatrick - Balerno, GB6
Michael Spedding - Edinburgh, GB6

Assignee:

Syntex (U.S.A.) Inc. - Palo Alto CA

International Classification:

A61K 3147
C07D45503

US Classification:

5142332

Abstract:

Compounds of formulas (1) and (2): ##STR1## in which: X and Y are independently hydrogen, hydroxy, lower alkyl, lower alkoxy or halo, or X and Y taken together is methylenedioxy or ethylene-1,2-dioxy; W is oxygen or sulfur; and Z is --R. sup. 1, --OR. sup. 2 or --NR. sup. 3 R. sup. 4, wherein R. sup. 1 is lower alkyl, lower haloalkyl, cycloalkyl, optionally substituted phenyl or phenyl lower alkyl, or heteroaryl; R. sup. 2 is lower alkyl, optionally substituted phenyl or phenyl lower alkyl; R. sup. 3 and R. sup. 4 are independently hydrogen, alkyl, optionally substituted phenyl or phenyl lower alkyl; or R. sup. 3 and R. sup. 4 taken together with the nitrogen to which they are attached represent a heterocycle of the formula: ##STR2## wherein A is --(CH. sub. 2). sub. m, --N(R. sup. 5)-- or oxygen, in which m is an integer of 0-2 and R. sup. 5 is hydrogen or lower alkyl; or a pharmaceutically acceptable salt thereof, are useful as. alpha. sub.