Robin Monica Clark

US Patent:

6376500, Apr 23, 2002

Filed:

Mar 8, 2001

Appl. No.:

09/803078

Inventors:

Robin Douglas Clark - Palo Alto CA
Counde OYang - Sunnyvale CA

Assignee:

Syntex (U.S.A.) LLC - Palo Alto CA

International Classification:

A01N 4354

US Classification:

514258, 514259, 544279, 544284, 544287

Abstract:

This invention relates to compounds which are generally alpha -receptor antagonists and which are represented by Formula I: wherein the substituents are as defined in the specification; or pharmaceutically acceptable salts, hydrates, or N-oxides thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their use as therapeutic agents, and a process for their preparation.

US Patent:

6472536, Oct 29, 2002

Filed:

Sep 19, 2000

Appl. No.:

09/666065

Inventors:

Keith Roger Bley - Mountain View CA
Robin Douglas Clark - Palo Alto CA
Alam Jahangir - San Jose CA
Bruce Andrew Kowalczyk - Redwood City CA
Francisco Javier Lopez-Tapia - Fremont CA
Alexander Victor Muehldorf - Sunnyvale CA
Counde OYang - Sunnyvale CA
Thomas Weitao Sun - Fremont CA

Assignee:

Syntex (U.S.A.) LLC - Palo Alto CA

International Classification:

C07D23350

US Classification:

5483111

Abstract:

This invention relates to IP receptor antagonists selected from the group of compounds represented by Formula I: where: R is a group represented by formula (A), (B) or (C); and other substituents as defined in the specification, and their pharmaceutically acceptable salts or crystal forms thereof; and pharmaceutical compositions containing them; and methods for their use as therapeutic agents.

US Patent:

6596876, Jul 22, 2003

Filed:

May 31, 2002

Appl. No.:

10/159589

Inventors:

Keith Roger Bley - Mountain View CA
Robin Douglas Clark - Palo Alto CA
Alam Jahangir - San Jose CA
Bruce Andrew Kowalczyk - Redwood City CA
Francisco Javier Lopez-Tapia - Fremont CA
Alexander Victor Muehldorf - Sunnyvale CA
Counde OYang - Sunnyvale CA
Thomas Weitao Sun - Fremont CA

Assignee:

Syntex (U.S.A.) LLC - Palo Alto CA

International Classification:

C07D23350

US Classification:

5483315

Abstract:

This invention relates to IP receptor antagonists selected from the group of compounds represented by Formula I: where: R is a group represented by formula (A), (B) or (C); âand other substituents as defined in the specification, and their pharmaceutically acceptable salts or crystal forms thereof; and pharmaceutical compositions containing them; and methods and their use as therapeutic agents.

US Patent:

6693200, Feb 17, 2004

Filed:

Apr 29, 2003

Appl. No.:

10/425778

Inventors:

Keith Roger Bley - Mountain View CA
Robin Douglas Clark - Palo Alto CA
Alam Jahangir - San Jose CA
Bruce Andrew Kowalczyk - Redwood City CA
Francisco Javier Lopez-Tapia - Fremont CA
Alexander Victor Muehldorf - Sunnyvale CA
Counde OYang - Sunnyvale CA
Thomas Weitao Sun - Fremont CA

Assignee:

Syntex (U.S.A.) LLC - Palo Alto CA

International Classification:

C07D23350

US Classification:

5483315, 544139, 5483111, 5483114, 5483127

Abstract:

This invention relates to IP receptor antagonists selected from the group of compounds represented by Formula I: where: R is a group represented by formula (A), (B) or (C); and other substituents as defined in the specification, and their pharmaceutically acceptable salts or crystal forms thereof; and pharmaceutical compositions containing them; and methods for their use as therapeutic agents.

US Patent:

6787535, Sep 7, 2004

Filed:

Jun 6, 2002

Appl. No.:

10/164660

Inventors:

Colin Charles Beard - Palo Alto CA
Robin Douglas Clark - Palo Alto CA
Lawrence Emerson Fisher - Mountain View CA
David Bruce Repke - Milpitas CA
David George Putman - Saratoga CA

Assignee:

Syntex (U.S.A.) LLC - Palo Alto CA

International Classification:

A61K 3133

US Classification:

514183, 51425409, 514415, 544366, 544358, 544373, 548452, 548469, 548511, 548503

Abstract:

This invention relates to compounds which have generally 5-HT6 receptor affinity and which are represented by Formula I: wherein one of R , R or R is a group of general Formula B, wherein W is a âCHâ group or a nitrogen atom, and the other substituents are as defined herein; or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their use as therapeutic agents, and methods of preparation thereof.

US Patent:

6790848, Sep 14, 2004

Filed:

Jun 14, 2002

Appl. No.:

10/172360

Inventors:

Andrew John Briggs - Mountain View CA
Robin Douglas Clark - Palo Alto CA
David Bruce Repke - Milpitas CA
Douglas Leslie Wren - Palo Alto CA

Assignee:

Syntex (U.S.A.) LLC - Palo Alto CA

International Classification:

C07D40304

US Classification:

51425409, 544373

Abstract:

This invention relates to compounds which have generally 5-HT6 receptor affinity and which are represented by Formula I: wherein R is SO âAr, Ar is aryl or heteroaryl; and R , R , R and R are as defined herein; or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their use as therapeutic agents, and methods of preparation thereof.

US Patent:

6825202, Nov 30, 2004

Filed:

Aug 9, 2002

Appl. No.:

10/215769

Inventors:

Jacob Berger - Los Altos Hills CA
Robin Douglas Clark - Lawai HI

Assignee:

Syntex (U.S.A.) LLC - Palo Alto CA

International Classification:

A61K 31495

US Classification:

51425411, 51425503, 514317, 514326, 544376, 544377, 544395, 546196, 546197, 546206, 546236

Abstract:

This invention relates to compounds which have generally 5-HT6 receptor affinity and which are represented by Formula (I): wherein Ar, R , R , R or R are as defined in the specification, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their use as therapeutic agents, and methods of preparation thereof.

US Patent:

6867204, Mar 15, 2005

Filed:

May 9, 2003

Appl. No.:

10/435732

Inventors:

Jacob Berger - Los Altos CA, US
Robin Douglas Clark - Lawai HI, US

Assignee:

Roche Palo Alto LLC - Palo Alto CA

International Classification:

C07D405/04
C07D405/14
A61K031/538
A61K031/551
A61P025/28

US Classification:

51421109, 5142305, 51421705, 514218, 540552, 540575, 540599, 540543, 544105, 544 71

Abstract:

Compounds of the formula: or pharmaceutically acceptable salts or prodrugs thereof, where each of n and p independently is 2 or 3, Y is —SO— or —SO—N(R)—, Zis CH or N, and R, R, R, R, R, R, R, R, Rand Rare as defined herein. The compounds have selective 5-HT6 affinity and are useful in the treatment of certain CNS disorders. Also provided are compositions comprising, methods for using, and methods for preparing Compounds of Formula I.