Robin N Lee

US Patent:

20110212138, Sep 1, 2011

Filed:

Sep 4, 2009

Appl. No.:

13/060225

Inventors:

Mary L. Houchin - Rockville MD, US
Robin H. Lee - San Diego CA, US
Hong Qi - San Diego CA, US
Greg Oehrtman - San Diego CA, US
Robert N. Jennings - San Diego CA, US
Scott H. Coleman - San Diego CA, US

International Classification:

A61K 9/00
A61K 38/00
A61K 38/22
A61K 38/28
A61K 38/38
A61K 31/60
A61K 31/135
A61P 3/10
A61P 3/08
A61P 3/00
A61P 3/04
A61P 3/06

US Classification:

424400, 514 48, 514 58, 514 59, 514 69, 514 74, 514159, 514649

Abstract:

The disclosure provides one-component, injectable, sustained release formulations which comprise microspheres containing active pharmaceutical ingredients (e.g., exenatide), wherein the microspheres are suspended in a non-aqueous carrier. The non-aqueous carrier can be an oil, a fractionated oil, triglycerides, diglycerides, monoglycerides, propylene glycol fatty acid diesters, and the like. The formulations offer distinct advantages of long shelf life for the stability and potency of the formulation and sustained release of active pharmaceutical ingredients to reduce the frequency of medication dosing and to increase patient compliance.

US Patent:

20140378418, Dec 25, 2014

Filed:

Jun 29, 2012

Appl. No.:

14/130384

Inventors:

Helena I. Boshoff - Potomac MD, US
Cynthia S. Dowd - Washington DC, US
Emily R. Jackson - Springfield VA, US
Richard E. Lee - Cordova TN, US
Robin Lee - Cordova TN, US
Geraldine San Jose - Mios, FR

International Classification:

C07F 9/40
C12Q 1/533

US Classification:

514119, 558173, 435 78

Abstract:

In particular, the compound is effective to inhibit Dxr in (Mtb). The present invention relates to compounds having general formula (I) or (II)