Robyn Cathleen Reed

US Patent:

8404805, Mar 26, 2013

Filed:

Oct 5, 2009

Appl. No.:

12/573618

Inventors:

Christopher V. Nicchitta - Durham NC, US
James J. Wassenberg - Durham NC, US
Robyn C. Reed - Durham NC, US

Assignee:

Duke University - Durham NC

International Classification:

C07K 14/435

US Classification:

530350, 5142631

Abstract:

The presently disclosed subject matter discloses characterization of interactions between ligands and Hsp90 proteins, including GRP94, wherein ligand binding to the N-terminal nucleotide binding domain of GRP94 elicits a conformational change that converts the GRP94 from an inactive to an active conformation, and wherein the chaperone and peptide-binding activities of the GRP94 are markedly stimulated. Also disclosed are purification, screening, and therapeutic methods pertaining to the biological activity of GRP94, and in some instances HSP90, based upon the characterization of ligand interactions of Hsp90 peptide-binding proteins, including GRP94.

US Patent:

8498100, Jul 30, 2013

Filed:

May 14, 2012

Appl. No.:

13/470633

Inventors:

Eric Joseph Wahl - Kirkland WA, US
David C. Vandervoort - Seattle WA, US
Todd David Pleake - Sammamish WA, US
Rob Huala - Bellevue WA, US
Summer L. Schneider - Seattle WA, US
Robyn Rebecca Reed McLaughlin - Seattle WA, US
Matthew David Mickelson - Seattle WA, US
Joel Lawrence Pelley - Bellevue WA, US
Timothy C. Shaw - Sammamish WA, US
Ralf Groene - Kirkland WA, US
Hua Wang - Sammamish WA, US
Christopher Harry Stoumbos - Sammamish WA, US
Karsten Aagaard - Monroe WA, US

Assignee:

Microsoft Corporation - Redmond WA

International Classification:

G06F 1/16

US Classification:

36167917, 36167928, 36167929

Abstract:

Flexible hinge and removable attachment techniques are described. In one or more implementations, a flexible hinge is configured to communicatively and physically couple an input device to a computing device and may implement functionality such as a support layer and minimum bend radius. The input device may also include functionality to promote a secure physical connection between the input device and the computing device. One example of this includes use of one or more protrusions that are configured to be removed from respective cavities of the computing device along a particular axis but mechanically bind along other axes. Other techniques include use of a laminate structure to form a connection portion of the input device.

US Patent:

8564944, Oct 22, 2013

Filed:

Oct 15, 2012

Appl. No.:

13/651726

Inventors:

Robyn Rebecca Reed McLaughlin - Seattle WA, US
Summer L. Schneider - Seattle WA, US
Eric Joseph Wahl - Kirkland WA, US
James H. Wise - Valparaiso IN, US
Camilo Leon - Redmond WA, US
Karsten Aagaard - Monroe WA, US
Thomas Charles Oliver - Windsor CO, US

Assignee:

Microsoft Corporation - Redmond WA

International Classification:

G06F 1/16

US Classification:

36167927, 36167917, 36167929, 335285, 16320

Abstract:

Flux fountain techniques are described. In one or more implementations, an apparatus includes a cover configured to be disposed over at least a portion of a display device of a computing device that is configured as a tablet and a connection portion attached to the cover using a flexible hinge. The connection portion is configured to be physically coupled to the computing device using a magnetic coupling device. The magnetic coupling device includes a first magnet that is disposed in the connection portion such that a magnetic field is aligned along an axis and second and third magnets are disposed in the connection portion at opposing sides of the first magnet from each other. The second and third magnets have respective magnetic fields that are aligned along a respective axis that is substantially perpendicular to the axis of the magnetic field of the first magnet.

US Patent:

8570725, Oct 29, 2013

Filed:

Oct 12, 2012

Appl. No.:

13/651327

Inventors:

Eric Joseph Wahl - Kirkland WA, US
David C. Vandervoort - Seattle WA, US
Todd David Pleake - Sammamish WA, US
Rob Huala - Bellevue WA, US
Summer L. Schneider - Seattle WA, US
Robyn Rebecca Reed McLaughlin - Seattle WA, US
Matthew David Mickelson - Seattle WA, US
Joel Lawrence Pelley - Bellevue WA, US
Timothy C. Shaw - Sammamish WA, US
Ralf Groene - Kirkland WA, US
Hua Wang - Sammamish WA, US
Christopher Harry Stoumbos - Sammamish WA, US
Karsten Aagaard - Monroe WA, US

Assignee:

Microsoft Corporation - Redmond WA

International Classification:

G06F 1/16

US Classification:

36167909, 36167915, 36167917, 36167927, 36167928, 36167929

Abstract:

Flexible hinge and removable attachment techniques are described. In one or more implementations, a flexible hinge is configured to communicatively and physically couple an input device to a computing device and may implement functionality such as a support layer and minimum bend radius. The input device may also include functionality to promote a secure physical connection between the input device and the computing device. One example of this includes use of one or more protrusions that are configured to be removed from respective cavities of the computing device along a particular axis but mechanically bind along other axes. Other techniques include use of a laminate structure to form a connection portion of the input device.

US Patent:

20030054996, Mar 20, 2003

Filed:

Aug 1, 2002

Appl. No.:

10/210333

Inventors:

Christopher Nicchitta - Durham NC, US
James Wassenberg - Durham NC, US
Meredith Rosser - Durham NC, US
Robyn Reed - Durham NC, US

International Classification:

A61K038/17
C12N009/22

US Classification:

514/012000, 435/199000

Abstract:

The present invention discloses characterization of interactions between ligands and Hsp90 proteins, including GRP94, wherein ligand binding to the N-terminal nucleotide binding domain of GRP94 elicits a conformational change that converts the GRP94 from an inactive to an active conformation, and wherein the chaperone and peptide-binding activities of the GRP94 are markedly stimulated. Also disclosed are purification, screening, and therapeutic methods pertaining to the biological activity of GRP94, and in some instances HSP90, based upon the characterization of ligand interactions of Hsp90 peptide-binding proteins, including GRP94.

US Patent:

20130229354, Sep 5, 2013

Filed:

Aug 2, 2012

Appl. No.:

13/565124

Inventors:

Eric Joseph Wahl - Kirkland WA, US
David C. Vandervoort - Seattle WA, US
Todd David Pleake - Sammamish WA, US
Rob Huala - Bellevue WA, US
Summer L. Schneider - Seattle WA, US
Robyn Rebecca Reed McLaughlin - Seattle WA, US
Matthew David Mickelson - Seattle WA, US
Joel Lawrence Pelley - Bellevue WA, US
Timothy C. Shaw - Sammamish WA, US
Ralf Groene - Kirkland WA, US
Hua Wang - Sammamish WA, US
Christopher Harry Stoumbos - Sammamish WA, US
Karsten Aagaard - Monroe WA, US

International Classification:

G06F 3/02

US Classification:

345169

Abstract:

Flexible hinge and removable attachment techniques are described. In one or more implementations, a flexible hinge is configured to communicatively and physically couple an input device to a computing device and may implement functionality such as a support layer and minimum bend radius. The input device may also include functionality to promote a secure physical connection between the input device and the computing device. One example of this includes use of one or more protrusions that are configured to be removed from respective cavities of the computing device along a particular axis but mechanically bind along other axes. Other techniques include use of a laminate structure to form a connection portion of the input device.

US Patent:

20130229756, Sep 5, 2013

Filed:

May 14, 2012

Appl. No.:

13/471237

Inventors:

Robyn Rebecca Reed McLaughlin - Seattle WA, US
Summer L. Schneider - Seattle WA, US
Eric Joseph Wahl - Kirkland WA, US
James H. Wise - Valparaiso IN, US
Camilo Leon - Redmond WA, US
Karsten Aagaard - Monroe WA, US
Thomas Charles Oliver - Windsor CO, US

International Classification:

G06F 1/16

US Classification:

3616794, 220230

Abstract:

Flux fountain techniques are described. In one or more implementations, an apparatus includes a cover configured to be disposed over at least a portion of a display device of a computing device that is configured as a tablet and a connection portion attached to the cover using a flexible hinge. The connection portion is configured to be physically coupled to the computing device using a magnetic coupling device. The magnetic coupling device includes a first magnet that is disposed in the connection portion such that a magnetic field is aligned along an axis and second and third magnets are disposed in the connection portion at opposing sides of the first magnet from each other. The second and third magnets have respective magnetic fields that are aligned along a respective axis that is substantially perpendicular to the axis of the magnetic field of the first magnet.

US Patent:

20130229757, Sep 5, 2013

Filed:

Aug 1, 2012

Appl. No.:

13/564520

Inventors:

Eric Joseph Wahl - Kirkland WA, US
David C. Vandervoort - Seattle WA, US
Todd David Pleake - Sammamish WA, US
Rob Huala - Bellevue WA, US
Summer L. Schneider - Seattle WA, US
Robyn Rebecca Reed McLaughlin - Seattle WA, US
Matthew David Mickelson - Seattle WA, US
Joel Lawrence Pelley - Bellevue WA, US
Timothy C. Shaw - Sammamish WA, US
Ralf Groene - Kirkland WA, US
Hua Wang - Sammamish WA, US
Christopher Harry Stoumbos - Sammamish WA, US
Karsten Aagaard - Monroe WA, US

International Classification:

G06F 1/16

US Classification:

3616794

Abstract:

Flexible hinge and removable attachment techniques are described. In one or more implementations, a flexible hinge is configured to communicatively and physically couple an input device to a computing device and may implement functionality such as a support layer and minimum bend radius. The input device may also include functionality to promote a secure physical connection between the input device and the computing device. One example of this includes use of one or more protrusions that are configured to be removed from respective cavities of the computing device along a particular axis but mechanically bind along other axes. Other techniques include use of a laminate structure to form a connection portion of the input device.