- Basel, CH - Philadelphia PA, US Elena Orlando - Somerville MA, US Roderick O'Connor - Philadelphia PA, US Carl H. June - Merion Station PA, US
International Classification:
C12N 5/0783 C12Q 1/54 C07K 14/705 G01N 33/50
Abstract:
The disclosure provides methods of making CAR-expressing immune effector cells (e.g., T cells, or NK cells), and compositions and reaction mixtures comprising the same. The disclosure further provides methods of using said CAR-expressing immune effector cells.
Activation And Expansion Of T Cell Subsets Using Biocompatible Solid Substrates With Tunable Rigidity
- New York NY, US - Philadelphia PA, US Keyue Shen - Cambridge MA, US Hueli Hao - Cleveland OH, US Roderick O'Connor - Philadelphia PA, US
Assignee:
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK - New York NY
International Classification:
A61K 35/14 C12N 5/0783
US Classification:
4241841, 435375
Abstract:
The present invention provides compositions and methods for activation and expansion of T cells using a biocompatible solid substrate with tunable rigidity. Rigidity of a substrate is an important parameter that can be used to control the overall expansion and differentiation of T cells.