Roger Duane Calhoon

US Patent:

57598282, Jun 2, 1998

Filed:

Sep 20, 1994

Appl. No.:

8/309512

Inventors:

Rony Tal - Richmond CA
David H. Gelfand - Oakland CA
Roger D. Calhoon - San Diego CA
Arie Ben-Bassat - Gainesville FL
Moshe Benziman - Jerusalem, IL
Hing Cheung Wong - San Ramon CA

Assignee:

Weyerhaeuser - Federal Way WA

International Classification:

C12N 1563
C12N 1570
C12N 1574
C12P 104

US Classification:

4351723

Abstract:

The present invention provides the nucleotide sequences of Acetobacter operons, cdg operons encoding genes for the biosynthesis and degradation of cyclic diguanosine monophosphate (c-di-GMP). Specifically, the nucleotide sequences and deduced amino acid sequences of 3 phosphodiesterases isozymes, 3 diguanylate cyclase isozymes, and 2 polypeptides of unidentified function are provided. Also provided for are various strains of microorganisms, including Acetobacter cells genetically manipulated so as to produce elevated and/or reduced levels of one or more cdg operon encoded proteins.