Roger O Heim from 2131 Caminito Del Barco, Del Mar, CA 92014, age 62, Phone: 8584817112

Us Patents

Long Wavelength Engineered Fluorescent Proteins
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US Patent:

6403374, Jun 11, 2002
Filed:

Dec 16, 1999
Appl. No.:

09/465142
Inventors:

Roger Y. Tsien - La Jolla CA
S. James Remington - Eugene OR
Andrew B. Cubitt - San Diego CA
Roger Heim - Del Mar CA
Mats F. OrmÃ¶ - Huddinge, SE
Assignee:

The Regents of the University of California - Oakland CA
International Classification:

C12N 500
US Classification:

435325, 435410, 4352523, 43525233, 43525411, 4353201, 536 231, 536 236, 536 234
Abstract:

Engineered fluorescent proteins, nucleic acids encoding them and methods of use are provided.

Long Wavelength Engineered Fluorescent Proteins
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US Patent:

6780975, Aug 24, 2004
Filed:

Feb 5, 2002
Appl. No.:

10/071976
Inventors:

Roger Y. Tsien - La Jolla CA
S. James Remington - Eugene OR
Andrew B. Cubitt - San Diego CA
Roger Heim - Del Mar CA
Mats F. OrmÃ¶ - Huddinge, SE
Assignee:

The Regents of the University of California - Oakland CA
Vertex Pharmaceuticals (San Diego) LLC - San Diego CA
State of Oregon Acting by and through the State Board of Higher Education on behalf of the University of Oregon - Eugene OR
International Classification:

C07K 1700
US Classification:

530350, 536 231
Abstract:

Engineered fluorescent proteins, nucleic acids encoding them and methods of use are provided.

Modified Green Fluorescent Proteins
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US Patent:

6800733, Oct 5, 2004
Filed:

Dec 17, 2001
Appl. No.:

10/024686
Inventors:

Roger Y. Tsien - La Jolla CA
Roger Heim - Del Mar CA
Assignee:

The Regents of the University of California - Oakland CA
International Classification:

C07K 14435
US Classification:

530350, 530855, 536 235
Abstract:

Modifications in the sequence of Aequorea wild-type GFP provide products having markedly different excitation and emission spectra from corresponding products from wild-type GFP. In one class of modifications, the product derived from the modified GFP exhibits an alteration in the ratio of two main excitation peaks observed with the product derived from wild-type GFP. In another class, the product derived from the modified GFP fluoresces at a shorter wavelength than the corresponding product from wild-type GFP. In yet another class of modifications, the product derived from the modified GFP exhibits only a single excitation peak and enhanced emission relative to the product derived from wild-type GFP.

Tandem Fluorescent Protein Constructs
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US Patent:

6803188, Oct 12, 2004
Filed:

Jan 31, 1996
Appl. No.:

08/594575
Inventors:

Roger Y. Tsien - La Jolla CA
Roger Heim - Del Mar CA
Assignee:

The Regents of the University of California - Oakland CA
International Classification:

C07K 1400
US Classification:

435 6, 435 72, 435 74, 435 771, 435 772, 435 691, 435 697, 435183, 435212, 4352523, 4353201, 435325, 530350, 530402, 536 234, 536 241, 536 231
Abstract:

This invention provides tandem fluorescent protein construct including a donor fluorescent protein moiety, an acceptor fluorescent protein moiety and a linker moiety that couples the donor and acceptor moieties. The donor and acceptor moieties exhibit fluorescence resonance energy transfer which is eliminated upon cleavage. The constructs are useful in enzymatic assays.

Long Wavelength Engineered Fluorescent Proteins
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US Patent:

7560287, Jul 14, 2009
Filed:

Aug 23, 2004
Appl. No.:

10/924232
Inventors:

Roger Y. Tsien - La Jolla CA, US
S. James Remington - Eugene OR, US
Andrew B. Cubitt - San Diego CA, US
Roger Heim - Del Mar CA, US
Mats F. Ormö - Huddinge, SE
Assignee:

The Regents of the University of California - Oakland CA
State of Oregon acting by and through the State Board of Higher Education on behalf of the University of Oregon - Eugene OR
International Classification:

G01N 21/64
G01N 33/52
C12P 17/06
A61K 38/00
US Classification:

436176, 436546, 435125, 4352851, 4351721, 435968, 435 71, 435 772, 530402
Abstract:

Engineered fluorescent proteins, nucleic acids encoding them and methods of use are provided.

Tandem Fluorescent Protein Constructs
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US Patent:

20020164674, Nov 7, 2002
Filed:

Jan 25, 2002
Appl. No.:

10/057505
Inventors:

Roger Tsien - La Jolla CA, US
Roger Heim - Del Mar CA, US
Andrew Cubitt - San Diego CA, US
Assignee:

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
International Classification:

C12Q001/37
C07K014/435
US Classification:

435/023000, 530/350000
Abstract:

This invention provides tandem fluorescent protein construct including a donor fluorescent protein moiety, an acceptor fluorescent protein moiety and a linker moiety that couples the donor and acceptor moieties. The donor and acceptor moieties exhibit fluorescence resonance energy transfer which is eliminated upon cleavage. The constructs are useful in enzymatic assays.

Tandem Fluorescent Protein Constructs
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US Patent:

20100233726, Sep 16, 2010
Filed:

Nov 4, 2009
Appl. No.:

12/612580
Inventors:

Roger Y. Tsien - La Jolla CA, US
Roger Heim - Del Mar CA, US
Andrew Cubitt - San Diego CA, US
Assignee:

The Regents of the University of California - Oakland CA
Invitrogen Corporation - Carlsbad CA
International Classification:

G01N 33/53
C07K 14/00
C07H 21/00
C12N 15/74
C12N 1/21
C12N 5/10
US Classification:

435 71, 530350, 536 231, 4353201, 43525233, 435325
Abstract:

This invention provides tandem fluorescent protein construct including a donor fluorescent protein moiety, an acceptor fluorescent protein moiety and a linker moiety that couples the donor and acceptor moieties. The donor and acceptor moieties exhibit fluorescence resonance energy transfer which is eliminated upon cleavage. The constructs are useful in enzymatic assays.

Long Wavelength Engineered Fluorescent Proteins
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US Patent:

61241288, Sep 26, 2000
Filed:

Aug 30, 1996
Appl. No.:

8/706408
Inventors:

Roger Y. Tsien - La Jolla CA
Andrew B. Cubitt - San Diego CA
Roger Heim - Del Mar CA
Mats F. Ormo - Huddinge, SE
S. James Remington - Eugene OR
Assignee:

The Regents of the University of California - Oakland CA
Aurora Biosciences - La Jolla CA
The University of Oregon - Eugene OR
International Classification:

C12N 120
C07H 2104
US Classification:

43525233
Abstract:

Engineered fluorescent proteins, nucleic acids encoding them and methods of use.

Roger Heim

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Roger Heim, born February 12, 1900, Paris, died September 17, 1979, was a French botanist specialising in mycology and tropical phytopathology. ...

Termites Et Champignons: Les Champignons Termitophiles D'Afrique Noire Et D'Asie Meridionale

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Author
Roger Heim

ISBN #
2850040088

Les Champignons Toxiques Et Hallucinogenes

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Author
Roger Heim

ISBN #
2850040134

Champignons D'Europe: Generalities-Ascomycetes-Basidiomycetes

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Author
Roger Heim

ISBN #
2850040428

Principal Investigator At Aspyrian Therapeutics Inc

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Location:

10575 Roselle St, San Diego, CA 92121

Industry:

Pharmaceuticals

Work:

Aspyrian Therapeutics, Inc
Principal Investigator at Aspyrian Therapeutics Inc
Vertex Pharmaceuticals Apr 1997 - Oct 2011
Research Scientist Ii
University of California San Diego Tsien Lab Sep 1992 - Apr 1997
Postgraduate Research Associate, Hhmi

Education:

Eth Zürich 1988 - 1992
Doctorates, Doctor of Philosophy Eth Zürich 1983 - 1988

Skills:

Assay Development
High Throughput Screening
Protein Chemistry
Biotechnology
Gpcrs
Drug Discovery
Fluorescence
Ion Channels
Biochemistry
Kinases
Life Sciences
Medicinal Chemistry
Drug Design
Pharmacology
Cell
Cell Culture
Drug Development
Lifesciences
In Vitro
Biomarkers
In Vivo
Purification
Lead Change
Drug Metabolism
Dmpk
Antibodies
Inflammation
Small Molecules
Cell Biology
Bioanalysis
Adme
Enzyme Assays
Laboratory Automation