Roger A Howell

US Patent:

20120148491, Jun 14, 2012

Filed:

Dec 9, 2011

Appl. No.:

13/315775

Inventors:

John M. Akudugu - Summit NJ, US
Venkata S. V. P. Neti - Lake Hiawatha NJ, US
Roger W. Howell - Millington NJ, US

Assignee:

UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY - Somerset NJ

International Classification:

A61K 51/04
C40B 30/06
G01N 21/64
A61P 35/00
C12Q 1/02

US Classification:

424 165, 435 29, 506 10

Abstract:

Disclosed is a method for predicting the optimal amounts of radiopharmaceutical and/or chemotherapy agents to administer to a patient, by determining the level of saturation of the therapeutic agents in the patient's cells. The method comprises measuring cellular incorporation of the candidate therapeutic agents in a target cell population on a cell-by-cell basis. The method is able to identify an optimal cocktail of therapeutic agents for treatment of a disease. A method of high-throughput drug discovery incorporating this method, and a 2-stage targeting method of treating a disease using this method are also disclosed.

US Patent:

62018523, Mar 13, 2001

Filed:

Apr 11, 1997

Appl. No.:

8/840144

Inventors:

Sreekrishna Murty Goddu - Kearny NJ
Roger W. Howell - Millington NJ
Dandamudi V. Rao - Basking Ridge NJ

Assignee:

University of Medicine & Denistry of New Jersey - Piscataway NJ

International Classification:

G21K 300

US Classification:

378159

Abstract:

A variable attenuation apparatus for use with a radiation-blocking liquid and a radiation source having an attenuation chamber capable of containing a layer of the radiation-blocking liquid and an adjustment device for selectively metering the thickness of the layer of the radiation-blocking liquid, whereby changes in the thickness of the layer alter the radiation transmitted through the attenuation chamber. In one embodiment, an adjustment device includes a reservoir for holding the radiation-blocking liquid and a siphon connection device for allowing the transfer of the radiation-blocking liquid between the reservoir and the attenuation chamber, wherein the thickness of the layer in the attenuation chamber varies in response to changes in elevation of said reservoir, so that an increase in the thickness of the layer causes a drop in the radiation transmitted through the attenuation chamber. A substantially linear increase in the thickness of the layer in the attenuation chamber may yield a substantially exponential drop in the radiation dose rate transmitted through the attenuation chamber. A desired dose rate pattern, such as an exponential dose rate pattern, may be delivered by the apparatus.

US Patent:

20150265730, Sep 24, 2015

Filed:

Oct 28, 2014

Appl. No.:

14/526041

Inventors:

- New Brunswick NJ, US
Venkata S. Neti - Lake Hiawatha NJ, US
Roger W. Howell - Millington NJ, US

International Classification:

A61K 51/04
A61K 31/704

Abstract:

Disclosed is a method for predicting the optimal amounts of radiopharmaceutical and/or chemotherapy agents to administer to a patient, by determining the level of saturation of the therapeutic agents in the patient's cells. The method comprises measuring cellular incorporation of the candidate therapeutic agents in a target cell population on a cell-by-cell basis. The method is able to identify an optimal cocktail of therapeutic agents for treatment of a disease. A method of high-throughput drug discovery incorporating this method, and a 2-stage targeting method of treating a disease using this method are also disclosed.

US Patent:

20140275709, Sep 18, 2014

Filed:

Mar 14, 2014

Appl. No.:

14/213231

Inventors:

- New Brunswick NJ, US
Han Wu - Kearny NJ, US
Roger W. Howell - Millington NJ, US

Assignee:

RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY - New Brunswick NJ

International Classification:

A61N 5/10

US Classification:

600 1

Abstract:

A system, method and computer program product to determine radiation dose from radionuclides used to treat a patient in need thereof. The present invention allows users to visualize and understand the impact of radionuclide choice, distribution of activity in the cell, distribution of activity among the cells, cell dimensions, cell separation distance, cluster size, and radiobiological response parameters on the capacity to kill populations of cells. All of these parameters can play a substantial role in determining the surviving fraction of cells. Accordingly, this system, method and computer program product can assist in designing treatment plans for therapeutic radiopharmaceuticals suited to individual needs.