Roger A O'Neill from San Carlos, CA

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Fluorescent Dyes, Energy Transfer Couples And Methods
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US Patent:

7091348, Aug 15, 2006
Filed:

Jul 1, 2003
Appl. No.:

10/612297
Inventors:

Roger O'Neill - San Carlos CA, US
Peter V. Fisher - Hayward CA, US
Assignee:

Guava Technologies, Inc. - Hayward CA
International Classification:

C07D 209/06
C07D 215/04
C07D 487/02
US Classification:

544280, 546152, 548455
Abstract:

Fluorescent dyes, fluorescence energy transfer dye couples, multi-color dye sets, can be employed in art-recognized assays and certain novel methods, such as in proximity assays.

Exchangeable Flow Cell Assembly With A Suspended Capillary
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US Patent:

7320775, Jan 22, 2008
Filed:

May 14, 2002
Appl. No.:

10/146019
Inventors:

Thomas E. Kochy - Redwood City CA, US
Roger A. O'Neill - San Carlos CA, US
Terah W. Smiley - Walnut Creek CA, US
Vidal O. Smith - Newark CA, US
Assignee:

Guava Technologies, Inc. - Hayward CA
International Classification:

G01N 15/06
G01N 33/00
G01N 33/48
G01N 1/10
G01N 21/01
US Classification:

422 681, 422 50, 422 55, 422 81, 422 82, 422 8205, 422 99, 422100, 422101, 422102, 422103, 422104, 436 43, 436 52, 436164, 436172, 73 101, 73 102, 73 5301, 4352871, 4352873, 4352887, 356244, 356246, 204601
Abstract:

There is provided a flow cell assembly in which a shuttle supports and positions a capillary with its end extending beyond the shuttle. The flow cell assembly facilitates the replacement of a flow cell which is damaged or with flow cells having capillaries of different size or shape.

Methods And Devices For Analyte Detection
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US Patent:

7846676, Dec 7, 2010
Filed:

Oct 30, 2007
Appl. No.:

11/981404
Inventors:

Tom Weisan Yang - Cupertino CA, US
Arunashree Bhamidipati - Palo Alto CA, US
Andrei V. Bordunov - Campbell CA, US
James Eugene Knittle - San Jose CA, US
Roger A. O'Neill - San Carlos CA, US
Karl O. Voss - Foster City CA, US
Assignee:

Cell Biosciences, Inc. - Santa Clara CA
International Classification:

G01N 1/00
G01N 21/00
G01N 33/53
B01D 7/00
US Classification:

435 71, 422 8205, 422 8209, 422101, 436164, 436172, 204450, 204451, 204456, 204469
Abstract:

Methods for detecting one or more analytes, such as a protein, in a fluid path are provided. The methods include resolving, immobilizing and detecting one or more analytes in a fluid path, such as a capillary. Also included are devices and kits for performing such assays.

Methods And Devices For Analyte Detection
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US Patent:

7935308, May 3, 2011
Filed:

Oct 30, 2007
Appl. No.:

11/981405
Inventors:

Roger A. O'Neill - San Carlos CA, US
Marc Glazer - Mountain View CA, US
Tom Weisan Yang - Cupertino CA, US
Assignee:

Cell Biosciences, Inc. - Santa Clara CA
International Classification:

G01N 33/50
G01N 33/53
G01N 33/536
G01N 33/543
G01N 21/00
G01N 21/63
G01N 21/64
US Classification:

422 8205, 422 681, 422 81, 422 82, 422 8207, 422 8209, 422100, 422101, 435 71, 4352872, 4352885, 4352887, 436164, 436172
Abstract:

Methods for detecting one or more analytes, such as a protein, in a fluid path are provided. The methods include resolving, immobilizing and detecting one or more analytes in a fluid path, such as a capillary. Also included are devices and kits for performing such assays.

Methods And Devices For Analyte Detection
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US Patent:

7935479, May 3, 2011
Filed:

Mar 19, 2007
Appl. No.:

11/725769
Inventors:

Roger A. O'Neill - San Carlos CA, US
Marc Glazer - Sunnyvale CA, US
Tom W. Yang - Cupertino CA, US
Daniel J. Suich - Oakland CA, US
Karl O. Voss - Foster City CA, US
Assignee:

Cell Biosciences, Inc. - Santa Clara CA
International Classification:

G01N 33/50
G01N 33/53
G01N 33/536
G01N 33/543
G01N 21/00
G01N 21/63
G01N 21/64
US Classification:

435 4, 422 681, 422 81, 422 82, 422 8205, 422 8207, 435 71, 4352872, 4352885, 4352887, 436164, 436172
Abstract:

Methods for detecting one or more analytes, such as a protein, in a fluid path are described herein. In some embodiments a method includes resolving one or more analytes in a fluid path, such as, for example, a capillary. After the one or more analytes are resolved, the one or more analytes are bound to the fluid path upon activation of one or more triggerable agents disposed within the fluid path. The one or more analytes that are bound to the fluid path are detected within the fluid path.

Methods And Devices For Analyte Detection
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US Patent:

7935489, May 3, 2011
Filed:

Jul 19, 2005
Appl. No.:

11/185247
Inventors:

Roger A. O'Neill - San Carlos CA, US
Marc Glazer - Mountain View CA, US
Tom Weisan Yang - Cupertino CA, US
Assignee:

Cell Biosciences, Inc. - Santa Clara CA
International Classification:

G01N 33/50
G01N 33/53
G01N 33/536
G01N 33/543
G01N 21/00
G01N 21/63
G01N 21/64
US Classification:

435 71, 422 681, 422 81, 422 82, 422 8205, 422 8207, 422 8209, 422100, 422101, 4352872, 4352885, 4352887, 435164, 435172
Abstract:

Methods for detecting one or more analytes, such as a protein, in a fluid path are provided. The methods include resolving, immobilizing and detecting one or more analytes in a fluid path, such as a capillary. Also included are devices and kits for performing such assays.

Automated Micro-Volume Assay System
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US Patent:

8021611, Sep 20, 2011
Filed:

Apr 10, 2006
Appl. No.:

11/401699
Inventors:

David J. Roach - Los Gatos CA, US
Tom W. Yang - Cupertino CA, US
Roger A. O'Neill - San Carlos CA, US
Peter B. Vander Horn - Foster City CA, US
Assignee:

ProteinSimple - Santa Clara CA
International Classification:

B01L 9/06
B01L 9/00
US Classification:

422 63, 422562, 422564
Abstract:

An automated assay system is described with stations for placement of materials to be used in an assay of materials inside capillaries and an automated gripper for manipulating capillaries. The system includes a separation and immobilization station where reactions inside the capillaries take place and a detector station where photoemissions from the capillary reactions are detected. The photoemissions from the capillaries may be displayed as line graphs or in columns of a pseudo-gel image resembling the familiar Western gel blot. An automated control system has a user interface by which an operator can select a run protocol and define the locations of samples and reagents to be used in the protocol run. Following the setup the control system will cause the automated system to execute the protocol, then display the results in a selected display format.

Automatic Analysis Apparatus
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US Patent:

20040136870, Jul 15, 2004
Filed:

Oct 24, 2003
Appl. No.:

10/693080
Inventors:

Thomas Kochy - San Jose CA, US
Joseph Keto - San Francisco CA, US
Vidal Smith - Tracy CA, US
Roger O'Neill - San Carlos CA, US
International Classification:

G01N033/00
US Classification:

422/073000
Abstract:

An automatic analyzing apparatus in which liquid samples contained in an array of cuvettes or wells are presented sequentially to a suspended capillary of a particle analyzing apparatus. The analyzing apparatus includes a mechanism which has a support tray for supporting the array of cuvettes or wells and moves the tray in the x-y direction to bring individual cuvettes opposite the capillary and then lifts the tray to immerse the capillary in the liquid sample of the selected cuvette or well for sample analysis.