Rok Cerne from 6804 Studebaker Ln, Indianapolis, IN 46214, age 64, Phone: 3174780621

Name / Title

Company / Classification

Phones & Addresses

Rok Cerne
Principal

Ephysbio LLC
Nonclassifiable Establishments

1518 White Pne Cir, Trenton, NJ 08648

Resumes

Rok Cerne

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Location:

Greenwood, IN

Industry:

Pharmaceuticals

Work:

Eli Lilly and Company Feb 2011 - Mar 2018
Principal Research Scientist
Ephysbio 2009 - Oct 2011
Director Ion Channel Biology
Redpoint Bio 2004 - 2009
Research Fellow
Purdue Pharma L.p. 2002 - 2004
Senior Scientist
Duke University Medical Center Feb 1997 - Sep 2002
Research Assistant Professor

Education:

Iowa State University 1989 - 1993
Doctorates, Doctor of Philosophy, Physiology, Pharmacology Rutgers University

Skills:

In Vivo
Electrophysiology
High Throughput Screening
Neuroscience
Pharmacology
Gpcrs
In Vitro
Ion Channels
Drug Discovery
Assay Development
Cell Biology
Biomarkers
Biotechnology
Drug Development
Lifesciences

Metallurgical Laboratory Intern

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Location:

West Lafayette, IN

Work:

Caterpillar Inc.
Metallurgical Laboratory Intern

Us Patents

Non-Desensitizing Mutant Of The Transient Receptor Potential Trpm5 Ion Channel
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US Patent:

7875452, Jan 25, 2011
Filed:

Sep 30, 2008
Appl. No.:

12/285140
Inventors:

Robert W. Bryant - Princeton NJ, US
S. Paul Lee - Yardley PA, US
Rok Cerne - Lawrenceville NJ, US
M. N. Tulu Buber - Newtown PA, US
Ivona Bakaj - Cranbury NJ, US
Roy Kyle Palmer - Cranbury NJ, US
Assignee:

Redpoint Bio Corporation - Ewing NJ
International Classification:

C12N 5/10
C12N 15/12
C12N 15/63
C12N 1/21
US Classification:

435325, 435 691, 4352523, 4353201, 536 235
Abstract:

There exists a need in the art for high throughput screening assays that can identify compounds that specifically modulate the activity of fast-acting ion channels, such as TRPM5. Current methods, especially electrophysiological, suffer from a lack of sensitivity, rapid signal loss, low throughput, and are labor intensive. The claimed methods and compositions provide electrophysiology methods that allow prolonged sample testing and fluorescent assays with an optical readout that gives rapid readout of the results, has a high signal to noise background ratio, are easy to use, can be modified for automation and miniaturization, and provide verification that a compound specifically modulates TRPM5.

Use Of A Trpm5 Inhibitor To Regulate Insulin And Glp-1 Release
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US Patent:

8193168, Jun 5, 2012
Filed:

Feb 4, 2008
Appl. No.:

12/025488
Inventors:

S. Paul Lee - Newtown PA, US
Peihong Zhou - East Brunswick NJ, US
M. N. Tulu Buber - Newtown PA, US
Rok Cerne - Lawrenceville NJ, US
Robert Bryant - Princeton NJ, US
F. Raymond Salemme - Yardley PA, US
Gillian Morgan - Philadelphia PA, US
Assignee:

Redpoint Bio Corporation - Ewing NJ
International Classification:

A61K 31/655
A61K 31/415
US Classification:

514150, 514407, 514866
Abstract:

The present invention is directed to methods of enhancing insulin release, GLP-1 release, and insulin sensitivity, methods of increasing insulin gene expression, methods of decreasing gastric secretion and emptying and glucagons secretion, and methods of inhibiting food intake, and methods of treating diabetes mellitus, insulin resistance syndrome, hyperglycemia, and obesity comprising administering to a subject an effective amount of a TRPM5 inhibitor.

Hydrazone Derivatives And Uses Thereof
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US Patent:

20070207093, Sep 6, 2007
Filed:

Nov 3, 2006
Appl. No.:

11/592228
Inventors:

Robert Bryant - Princeton NJ, US
Roy Palmer - Cranbury NJ, US
Rok Cerne - Plainsboro NJ, US
Karnail Atwal - Pennington NJ, US
Seunghun Lee - Newtown PA, US
Anita Atwal - Pennington NJ, US
International Classification:

A61K 8/49
A61K 8/40
US Classification:

424049000, 514313000, 514408000, 514357000, 514419000, 514367000, 514394000, 514418000, 514639000, 514237500
Abstract:

The present invention is directed to the use of a compound having the formula wherein R, R, R, R, L, and Lare defined herein. The compounds of the present invention are useful as inhibitors of certain taste perceptions and functions. The invention is also directed to compositions comprising a compound according to the above formula.

Triaryl Substituted Imidazole Derivatives And Taste-Inhibiting Uses Thereof
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US Patent:

20070259875, Nov 8, 2007
Filed:

Apr 30, 2007
Appl. No.:

11/797082
Inventors:

Karnail Atwal - Pennington NJ, US
Anita Atwal - Pennington NJ, US
Robert Bryant - Princeton NJ, US
Seunghun Lee - Newton PA, US
Roy Palmer - Cranbury NJ, US
Rok Cerne - Lawrenceville NJ, US
International Classification:

A61K 31/53
A61K 31/501
A61K 31/497
A61K 31/506
A61K 31/4439
A61K 31/4164
US Classification:

514241000, 514252050, 514255050, 514256000, 514396000, 514341000
Abstract:

The present invention is directed to compositions containing and methods of using a compound having the formula: wherein R, Ar, Ar, and Arare defined herein. The compounds of the present invention are useful as inhibitors of certain taste perceptions and functions. The invention is also directed to compositions comprising a compound of the above formula.

Heterocyclic Compounds As Sweetener Enhancers
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US Patent:

20080249189, Oct 9, 2008
Filed:

Aug 22, 2007
Appl. No.:

11/843411
Inventors:

KARNAIL S ATWAL - Pennington NJ, US
Robert W. Bryant - Princeton NJ, US
Ivona Bakaj - Cranbury NJ, US
Roy Kyle Palmer - Cranbury NJ, US
Rok Cerne - Lawrenceville NJ, US
Anita B. Atwal - Pennington NJ, US
International Classification:

A61K 47/00
US Classification:

514772
Abstract:

The present invention is directed to the use of a compound of Formula Iand physiologically acceptable salts thereof wherein G, G, G, R, R, R, R, R, and Rare defined herein. Compounds according to Formula I can be used to enhance a sweet taste produced by a tastant. The invention is also directed to compositions comprising a compound according to the above formula. Other aspects of the invention provide methods, compounds, and compositions for improved food products wherein the food product comprises a compound according to Formula I and a reduced amount of a sweet tastant.

Modulation Of The Cooperativity Between The Ion Channels Trpm5 And Trpa1
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US Patent:

20090175848, Jul 9, 2009
Filed:

Sep 17, 2008
Appl. No.:

12/212508
Inventors:

S. Paul Lee - Newtown PA, US
Tulu Buber - Newtown PA, US
Rok Cerne - Lawrenceville NJ, US
Robert W. Bryant - Princeton NJ, US
International Classification:

A61K 39/395
C12N 5/06
C12N 5/08
A61K 31/7105
A61K 31/7088
C12Q 1/68
C12Q 1/44
US Classification:

4241301, 435375, 435366, 514 44, 435 29, 435 19
Abstract:

The present invention is related to modulating TRPA1 ion channel activity by targeting the ion channel TRPM5. The cooperativity between the ion channels can be used to modulate pain, mechanosensation and taste responses triggered through TRPA1 by modulating the activity of TRPM5

Heterocyclic Compounds As Sweetener Enhancers
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US Patent:

20100197813, Aug 5, 2010
Filed:

Feb 9, 2010
Appl. No.:

12/702921
Inventors:

Karnail S. ATWAL - Pennington NJ, US
Anita B. Atwal - Pennington NJ, US
Robert W. Bryant - Princeton NJ, US
Ivona Bakaj - Cranbury NJ, US
Roy Kyle Palmer - Cranbury NJ, US
Rok Cerne - Lawrenceville NJ, US
Assignee:

Redpoint Bio Corporation - Ewing NJ
International Classification:

A61K 47/12
A23L 1/22
A61K 47/14
A61K 47/18
A61K 47/22
A61P 43/00
US Classification:

514784, 426534, 426535, 514785, 514788
Abstract:

The present invention is directed to the use of a compound of Formula Iand physiologically acceptable salts thereof wherein G, G, G, R, R, R, R, R, and Rare defined herein. Compounds according to Formula I can be used to enhance a sweet taste produced by a tastant. The invention is also directed to compositions comprising a compound according to the above formula. Other aspects of the invention provide methods, compounds, and compositions for improved food products wherein the food product comprises a compound according to Formula I and a reduced amount of a sweet tastant.