Ronald D Black

US Patent:

20090155256, Jun 18, 2009

Filed:

Oct 17, 2008

Appl. No.:

12/253929

Inventors:

Ronald Black - Berwyn PA, US
Lars Ekman - La Jolla CA, US
Ivan Lieberburg - Berkeley CA, US
Michael Grundman - San Diego CA, US
James Callaway - San Diego CA, US
Keith M. Gregg - Goodyear AZ, US
Jack Steven Jacobsen - Ramsey NJ, US
Davinder Gill - Andover MA, US
Lioudmila Tchistiakova - Andover MA, US
Angela Widom - Acton MA, US

Assignee:

Wyeth - Madison NJ
Elan Pharma International Limited - Athlone

International Classification:

A61K 39/395
C07K 16/00
C07H 21/00
A61P 25/28

US Classification:

4241331, 4241391, 5303873, 536 231, 5303871

Abstract:

The invention provides methods of immunotherapy of Alzheimer's and similar diseases in which the regime administered to a patient depends on the ApoE genotype of the patient.

US Patent:

20100266505, Oct 21, 2010

Filed:

Oct 17, 2008

Appl. No.:

12/738396

Inventors:

Ronald Black - Berwyn PA, US
Lars Ekman - La Jolla CA, US
Ivan Lieberburg - Berkeley CA, US
Michael Grundman - San Diego CA, US
James Callaway - San Diego CA, US
Keith M. Gregg - Goodyear AZ, US
Jack Steven Jacobsen - Ramsey NJ, US
Davinder Gill - Andover MA, US
Lioudmila Tchistiakova - Andover MA, US
Angela Widom - Acton MA, US

Assignee:

Wyeth LLC - Madison NJ
Janssen Alzheimer Immunotherapy - Little Island, County Cork

International Classification:

A61K 49/06
A61K 39/395

US Classification:

424 93, 4241331

Abstract:

The invention provides methods of immunotherapy of Alzheimer's and similar diseases in which the regime administered to a patient depends on the ApoE genotype of the patient.

US Patent:

20120070379, Mar 22, 2012

Filed:

Sep 13, 2011

Appl. No.:

13/231903

Inventors:

Ronald Black - Berwyn PA, US
Lars Ekman - La Jolla CA, US
Ivan Lieberburg - Berkeley CA, US
Michael Grundman - San Diego CA, US
James Callaway - San Diego CA, US
Keith M. Gregg - Goodyear AZ, US
Jack Steven Jacobsen - Ramsey NJ, US
Davinder Gill - Andover MA, US
Lioudmila Tchistiakova - Andover MA, US
Angela Widom - Acton MA, US

Assignee:

Janssen Alzheimer Immunotherapy - Little Island
Wyeth LLC - Madison NJ

International Classification:

A61K 39/395
G06Q 90/00
A61K 39/00
A61K 49/00
A61P 25/28

US Classification:

424 92, 4241721, 4241331, 4241841, 705500

Abstract:

The invention provides methods of immunotherapy of Alzheimer's and similar diseases in which the regime administered to a patient depends on the ApoE genotype of the patient.

US Patent:

20130084245, Apr 4, 2013

Filed:

Feb 25, 2011

Appl. No.:

13/580866

Inventors:

Ronald Black - Audubon PA, US
Michael Grundman - San Diego CA, US

Assignee:

Wyeth LLC - Madison NJ
Janssen Alzheimer Immunotherapy - County Cork

International Classification:

A61K 51/04

US Classification:

424 189, 424 181

Abstract:

The present invention provides methods of monitoring Aβ-directed immunotherapy. The methods involve administering a PET ligand that binds to amyloid deposits and detecting the PET ligand in the brain to provide an indication of the level and/or distribution of amyloid deposits. Surprisingly, the data in the present application show that a statistically significant reduction in amyloid deposits occurs early and consistently among patients following initiation of treatment before statistically significant effects of most if not all other markers are detectable. In consequence, the present methods allow early detection of whether a patient is responding to the Aβ-directed immunotherapy and if necessary adjustment of the immunotherapy regime.

US Patent:

20130209453, Aug 15, 2013

Filed:

Apr 22, 2011

Appl. No.:

13/642845

Inventors:

Ronald Black - Audubon PA, US
Jack Steven Jacobsen - Ramsey NJ, US
Lioudmila Tchistiakova - Andover MA, US
Angela Widom - Acton MA, US
Davinder Gill - Andover MA, US
Lars Ekman - La Jolla CA, US
Ivan Lieberburg - Berkeley CA, US
Michael Grundman - San Diego CA, US
James Callaway - San Diego CA, US
Keith M. Gregg - Goodyear AZ, US
Wagner Zago - San Mateo CA, US
Manuel J. Buttini - Belvaux, LU

Assignee:

WYETH LLC - Madison NJ
JANSSEN ALZHEIMER IMMUNOTHERAPY - Dublin 2

International Classification:

A61K 39/395

US Classification:

4241331, 4241721, 435 792

Abstract:

The invention provides methods of immunotherapy of Alzheimer's and similar diseases in which the regime administered is monitored by measuring levels of tau.

US Patent:

39807550, Sep 14, 1976

Filed:

Dec 24, 1975

Appl. No.:

5/644015

Inventors:

Ronald F. Black - Philadelphia PA
Clarence P. Kurtz - Cherry Hill NJ
Robert J. Pasek - Langhorne PA

Assignee:

Rohm and Haas Company - Philadelphia PA

International Classification:

B01D 5334

US Classification:

423240

Abstract:

Chloromethyl methyl ether and di(chloromethyl) ether contaminants are removed from air in laboratories, industrial plants and other locales wherein chloromethyl ether (more accurately called chloromethyl methyl ether) and bis-chloromethyl ether are used for various purposes. Silica gel and/or activated alumina are employed for removing the chloromethyl ethers either with or without other contaminants from the gaseous atmosphere wherein they occur. The absorption of the ethers on the silica gel or activated alumina is carried out under conditions of temperature that have been found to result in the hydrolytic decomposition of these chloromethyl ethers, apparently by virtue of catalytic action occurrng on the surface of the silica gel or activated alumina. The decomposition of these ethers on contact with the silica gel or activated alumina results in the production of hydrogen chloride, as well as methylal, methanol, formaldehyde or mixtures thereof depending on the particular ether (CME, BCME or both) present in the contaminated stream.