Ronald W Cotton

US Patent:

20160150963, Jun 2, 2016

Filed:

Nov 5, 2014

Appl. No.:

14/534163

Inventors:

Michael Lee Roukes - Pasadena CA, US
Ronald James Cotton - Houston TX, US
Laurent Moreaux - Pasadena CA, US
Kenneth Shepard - Ossining NY, US
Athanassios Siapas - Pasadena CA, US
Andreas Tolias - Houston TX, US

International Classification:

A61B 5/00

Abstract:

An apparatus and method for detecting functional cellular activity within a volume of a tissue. The method includes inserting a three-dimensional array of optical emitters and optical detectors into a volume of a tissue, where the tissue volume includes one or more cells labeled with an optical reporter of cellular activity; illuminating the one or more cells with photons from the optical emitters of the three-dimensional array to generate optical signals from the optical reporter that labels the one or more cells; and detecting the optical signals using the optical detectors of the three-dimensional array, where the illumination includes one-photon excitation of the optical reporter.