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A word association and linking game apparatus and method for playing the game including a plurality of word fields having predetermined words therein, a plurality of empty fields corresponding to the word fields at a ratio of at least two word fields per empty field, at least one clue and a result arranged in a tournament like manner. At least two word fields link to a common empty field and the player must enter a word that is common to both as either a compound word or a well recognized phrase. Clues may be provided, such as in the form of a sentence, wherein the answer would also complete the sentence. The game includes a timing requirement where players would have limited time for filling in the empty fields. Electronic or computer versions utilizing software may also be provided.
Heteroaryl Piperidine Ether Allosteric Modulators Of The M4 Muscarinic Acetylcholine Receptor
Jianming BAO - Shanghai, CN Ronald FERGUSON - Rahway NJ, US Xiaolei GAO - Bridgewater NJ, US Scott HARRISON - West Point PA, US Sandra L. KNOWLES - Kenilworth NJ, US Michael Man-chu LO - Kenilworth NJ, US Jeffrey W. SCHUBERT - West Point PA, US - Rahway NJ, US - Shanghai, CN
The present invention is directed to heteroarylpiperidine ether compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.
Substituted Quinolizine Derivatives Useful As Hiv Integrase Inhibitors
- Rahway NJ, US Yonglian Zhang - Metuchen NJ, US Sherman Tim Waddell - Westfield NJ, US Andrew Stamford - Chatham NJ, US John S. Wai - Harleysville PA, US Paul J. Coleman - Harleysville PA, US John M. Sanders - Collegeville PA, US Ronald Ferguson - Scotch Plains NJ, US Thomas H. Graham - Quincy MA, US Hong Li - Edison NJ, US
The present invention relates to Substituted Quinolizine Derivatives of Formula (I):and pharmaceutically acceptable salts or prodrug thereof, wherein X, Y, R, R, R, R, R, Rand Rare as defined herein. The present invention also relates to compositions comprising at least one Substituted Quinolizine Derivative, and methods of using the Substituted Quinolizine Derivatives for treating or preventing HIV infection in a subject.
Inhibitors Of The Renal Outer Medullary Potassium Channel
Alexander PASTERNAK - Kenilworth NJ, US Barbara PIO - Kenilworth NJ, US Harry R. CHOBANIAN - Kenilworth NJ, US Zhi-Cai SHI - Kenilworth NJ, US Shuzhi DONG - Kenilworth NJ, US Yan GUO - Kenilworth NJ, US Shawn P. WALSH - Kenilworth NJ, US Zhiqiang GUO - Rahway NJ, US Ronald D. FERGUSON - Rahway NJ, US Brian CATO - Secaucus NJ, US - Rahway NJ, US
The present invention provides compounds of Formula (I) and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.
Inhibitors Of The Renal Outer Medullary Potassium Channel
- Rahway NJ, US Haifeng Tang - Metuchen NJ, US Jessica Frie - Perkasie PA, US Ronald Dale Ferguson - Scotch Plains NJ, US Zhiqiang Guo - Morganville NJ, US Zhi-Cai Shi - Monmouth Junction NJ, US Brian Cato - Secaucus NJ, US Qinghong Fu - Plainsboro NJ, US
The present invention provides compounds of Formula Iand the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.
Substituted Quinolizine Derivatives Useful As Hiv Integrase Inhibitors
- Rahway NJ, US Yonglian Zhang - Metuchen NJ, US Sherman Tim Waddell - Westfield NJ, US Andrew Stamford - Chatham NJ, US John S. Wai - Harleysville PA, US Paul J. Coleman - Harleysville PA, US John M. Sanders - Collegeville PA, US Ronald Ferguson - Scotch Plains NJ, US
The present invention relates to Substituted Quinolizine Derivatives of Formula (I): and pharmaceutically acceptable salts or prodrug thereof, wherein X, Y, R, R, R, R, R, Rand Rare as defined herein. The present invention also relates to compositions comprising at least one Substituted Quinolizine Derivative, and methods of using the Substituted Quinolizine Derivatives for treating or preventing HIV infection in a subject.
Jongwon LIM - , US Xianhai HUANG - , US Ronald D. FERGUSON - Rahway NJ, US Wei ZHOU - Rahway NJ, US Christopher W. BOYCE - Rahway NJ, US Phieng SILIPHAIVANH - Boston MA, US David J. WITTER - Boston MA, US Milana M. MALETIC - Rahway NJ, US Joseph A. KOZLOWSKI - Rahway NJ, US Kevin J. WILSON - Boston MA, US - Rahway NJ, US
Assignee:
Merck Sharp & Dohme Corp. - Rahway NJ
International Classification:
C07D 487/04 C07D 471/14 C07D 471/04
Abstract:
Disclosed are the ERK inhibitors of formula (I) and the pharmaceutically acceptable salts thereof. Also disclosed are methods of treating cancer using the compounds of formula (I). This invention also provides a pharmaceutical composition comprising an effective amount of at least one compound of formula (I) and a pharmaceutically acceptable carrier. This invention also provides a pharmaceutical composition comprising an effective amount of at least one compound of formula (I) and an effective amount of at least one other pharmaceutically active ingredient (such as, for example, a chemotherapeutic agent), and a pharmaceutically acceptable carrier. This invention also provides a method of inhibiting ERK (i.e., inhibiting the activity of ERK2) in a patient in need of such treatment comprising administering to said patient an effective amount of at least one compound of formula (I).
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Ronald Ferguson
Ronald Ferguson
About:
I'm a semi retired from the criminal justice field, and am playing music full time, as a solo act and also with a combo. Having been performing for 42 years professionally and it is truly a love o...
the U.S. Second Circuit Court of Appeals has ordered a new trial for Ronald Ferguson, former chief executive officer of General Re; Elizabeth Monrad, former chief financial officer of the company; Christopher Garand, former senior vice president; and Robert Graham, former assistant general counsel.
Court of Appeals for the 2nd Circuit dealt a significant setback to the Department of Justice in ordering new trials for Ronald Ferguson, General Reinsurances former chief executive; Elizabeth Monrad, Gen Res former chief financial officer; Christopher Garand, once a Gen Re senior vice president,
Sarah Ferguson looks over her shoulder on arrival at London's Westminster Abbey for her wedding to Prince Andrew. Her father, Ronald Ferguson, adjusts her dress while dress designer Lindka Cierach tidies her train.