Ronald B Gartenhaus

US Patent:

20040137474, Jul 15, 2004

Filed:

Oct 2, 2003

Appl. No.:

10/677701

Inventors:

Victor Levenson - Chicago IL, US
Ronald Gartenhaus - Northbrook IL, US

Assignee:

Northwestern University - Evanston IL

International Classification:

C12Q001/68

US Classification:

435/006000

Abstract:

The present invention relates to compositions and methods for cancer diagnostics, including but not limited to, cancer markers. In particular, the present invention provides methods of identifying methylation patterns in genes associated with specific cancers.

US Patent:

20110117576, May 19, 2011

Filed:

Oct 12, 2010

Appl. No.:

12/902722

Inventors:

Ronald Gartenhaus - Pikesville MD, US

International Classification:

G01N 33/566

US Classification:

435 723, 435 721

Abstract:

A novel gene, designated MCT-1 (for Multiple Copies in T-cell malignancy), is provided. A protein encoded by MCT-1, designated MCT-1, is also provided. Antisense oligonucleotides complementary to or homologous with a portion of MCT-1, substantially purified MCT-1, and methods of determining whether a cell is a tumor cell are also provided. The invention also includes monoclonal and polyclonal antibody preparations which bind with specificity to MCT-1. The invention further includes methods of determining whether a compound or a gene product is a modulator of MCT-1 expression, a method of reducing MCT-1 expression in a cell, and a method of conferring a growth advantage on a cell.

US Patent:

20200016160, Jan 16, 2020

Filed:

Sep 24, 2019

Appl. No.:

16/580988

Inventors:

Robert R. Redfield - Baltimore MD, US
Alonso Heredia - Washington DC, US
Charles Davis - Laurel MD, US
Ronald Gartenhaus - Pikesville MD, US
Edward A. Sausville - Edgewater MD, US

Assignee:

University of Maryland, Baltimore - Baltimore MD

International Classification:

A61K 31/519
A61K 31/4745
A61K 31/501
A61K 31/5377
A61K 45/06

Abstract:

Methods are provided for treating HIV and cancer in a subject in need thereof by administering to the subject therapeutically effective amounts of an mTOR inhibitor. Other methods are provided for treating subjects infected with HIV by administering to the subject therapeutically effective amounts of the mTOR inhibitor INK128, GSK2126458, AZD2014 or Torin-2.

US Patent:

20160339030, Nov 24, 2016

Filed:

May 19, 2016

Appl. No.:

15/159444

Inventors:

Robert R. Redfield - Baltimore MD, US
Alonso Heredia - Washington DC, US
Charles E. Davis - Laurel MD, US
Ronald B. Gartenhaus - Pikesville MD, US
Edward A. Sausville - Edgewater MD, US

Assignee:

University of Maryland, Baltimore - Baltimore MD

International Classification:

A61K 31/519
A61K 45/06
A61K 31/5377
A61K 31/4745
A61K 31/501

Abstract:

Methods are provided for treating HIV and cancer in a subject in need thereof by administering to the subject therapeutically effective amounts of an mTOR inhibitor. Other methods are provided for treating subjects infected with HIV by administering to the subject therapeutically effective amounts of the mTOR inhibitor INK128, GSK2126458, AZD2014 or Torin-2.