Ronald F Riley

US Patent:

6720184, Apr 13, 2004

Filed:

Oct 2, 2000

Appl. No.:

09/676835

Inventors:

Elaine W. Wang - Atlanta GA
Dennis C. Liotta - Stone Mountain GA
Ronald T. Riley - Athens GA

Assignee:

Emory University - Atlanta GA

International Classification:

G01N 3302

US Classification:

436 20, 436 71, 436815, 436 63, 436 64, 564507, 564224, 435 4, 435 15, 560196

Abstract:

This invention provides a method of altering the metabolism of sphingolipids in a cell comprising contacting the cell with a fumonisin, or an analog thereof. The invention also provides a method of detecting the consumption of a fumonisin or a fumonisin analog in a subject comprising (A) detecting, in a sample from the subject, the state of the metabolic pathway of sphingolipids and (B) comparing the state of the metabolic pathway to that of a normal subject, the presence of a change in the state of the metabolic pathway indicating the consumption of a fumonisin or a fumonisin analog. Also provided is a method of detecting the presence of a fumonisin or fumonisin analog contamination in a sample from a food or feed comprising detecting a reaction of the metabolic pathway of sphingolipids, the presence of the reaction indicating the presence of a fumonisin or fumonisin analog contamination. Furthermore, novel fumonisin analogs and compositions comprising fumonisins and fumonisin analogs are provided.

US Patent:

52328376, Aug 3, 1993

Filed:

Aug 5, 1991

Appl. No.:

7/740426

Inventors:

Alfred H. Merrill - Stone Mountain GA
Elaine W. Wang - Atlanta GA
Dennis C. Liotta - Stone Mountain GA
Ronald T. Riley - Athens GA

Assignee:

Emory University - Atlanta GA
The United States of America as represented by the Secretary of
Agriculture - Washington DC

International Classification:

C12Q 148

US Classification:

435 15

Abstract:

This invention provides a method of altering the metabolism of sphingolipids in a cell comprising contacting the cell with a fumonisin, or an analog thereof. The invention also provides a method of detecting the consumption of a fumonisin or a fumonisin analog in a subject comprising (A) detecting, in a sample from the subject, the state of the metabolic pathway of sphingolipids and (B) comparing the state of the metabolic pathway to that of a normal subject, the presence of a change in the state of the metabolic pathway indicating the consumption of a fumonisin or a fumonisin analog. Also provided is a method of detecting the presence of a fumonisin or fumonisin analog contamination in a sample from a food or feed comprising detecting a reaction of the metabolic pathway of sphingolipids, the presence of the reaction indicating the presence of a fumonisin or fumonisin analog contamination. Furthermore, novel fumonisin analogs and compositions comprising fumonisins and fumonisin analogs are provided.

US Patent:

61275786, Oct 3, 2000

Filed:

Apr 4, 1996

Appl. No.:

8/627499

Inventors:

Alfred H. Merrill - Stone Mountain GA
Elaine W. Wang - Atlanta GA
Dennis C. Liotta - Stone Mountain GA
Ronald T. Riley - Athens GA

Assignee:

Emory University - Atlanta GA
The United States of America as represented by the Secretary of
Agriculture - Washington DC

International Classification:

C07C21500

US Classification:

564507

Abstract:

This invention provides a method of altering the metabolism of sphingolipids in a cell comprising contacting the cell with a fumonisin, or an analog thereof. The invention also provides a method of detecting the consumption of a fumonisin or a fumonisin analog in a subject comprising (A) detecting, in a sample from the subject, the state of the metabolic pathway of sphingolipids and (B) comparing the state of the metabolic pathway to that of a normal subject, the presence of a change in the state of the metabolic pathway indicating the consumption of a fumonisin or a fumonisin analog. Also provided is a method of detecting the presence of a fumonisin or fumonisin analog contamination in a sample from a food or feed comprising detecting a reaction of the metabolic pathway of sphingolipids, the presence of the reaction indicating the presence of a fumonisin or fumonisin analog contamination. Furthermore, novel fumonisin analogs and compositions comprising fumonisins and fumonisin analogs are provided.

US Patent:

55188796, May 21, 1996

Filed:

Apr 2, 1993

Appl. No.:

8/042147

Inventors:

Alfred H. Merrill - Stone Mountain GA
Elaine W. Wang - Atlanta GA
Ronald T. Riley - Athens GA

Assignee:

Emory University - Atlanta GA
The United States of America as represented by the Secretary of
Agriculture - Washington DC

International Classification:

C12Q 100
G01N 3302
C07C 6934
C07C 6952

US Classification:

435 4

Abstract:

This invention provides a method of altering the metabolism of sphingolipids in a cell comprising contacting the cell with a fumonisin, or an analog thereof. The invention also provides a method of detecting the consumption of a fumonisin or a fumonisin analog in a subject comprising (A) detecting, in a sample from the subject, the state of the metabolic pathway of sphingolipids and (B) comparing the state of the metabolic pathway to that of a normal subject, the presence of a change in the state of the metabolic pathway indicating the consumption of a fumonisin or a fumonisin analog. Also provided is a method of detecting the presence of a fumonisin or fumonisin analog contamination in a sample from a food or feed comprising detecting a reaction of the metabolic pathway of sphingolipids, the presence of the reaction indicating the presence of a fumonisin or fumonisin analog contamination. Furthermore, novel fumonisin analogs and compositions comprising fumonisins and fumonisin analogs are provided.