Ronald Rodriguez - Glenwood MD, US Wasim Haider Chowdhury - Laurel MD, US
Assignee:
The Johns Hopkins University - Baltimore MD
International Classification:
A61K 48/00
US Classification:
424 932
Abstract:
The invention provides a packaging cell line for production of diphtheria toxin (DT) expressing, non-replicating adenovirus for use in suicide gene therapy of cancer cells, as well as production of immunotoxins. Also provided are methods for producing diphtheria toxin (DT) expressing, non-replicating adenovirus, methods for producing immunotoxins, and adenovirus and immunotoxins produced by those methods. Further provided are methods for making a cell resistant to diphtheria toxin.
Enhancement Of Adenoviral Oncolytic Activity By Modification Of The E1A Gene Product
Ronald Rodriguez - Glenwood MD, US Ying Li - Gibson Island MD, US
Assignee:
The Johns Hopkins University - Baltimore MD
International Classification:
A61K 31/70 C12N 15/74
US Classification:
514 44, 4353201, 435 914
Abstract:
The present invention relates to compositions and methods for enhancing the oncolytic activity of replication-competent, target cell-specific adenovirus vectors by modification of the E1A gene product. The target cell-specific replication-competent adenovirus vectors comprise a chimera of an adenovirus gene essential for replication, preferably an early gene, and the Androgen receptor (or a portion thereof) under the transcriptional control of a cell type-specific transcriptional regulatory element (TRE). By providing for cell type-specific transcription through the use of one or more cell type-specific TREs, the adenovirus vectors effect prostate-specific cytotoxicity due to selective replication.
Peptides For Targeting The Prostate Specific Membrane Antigen
Ronald Rodriguez - Glenwood MD, US Shawn E. Lupold - Ellicott City MD, US
Assignee:
The Johns Hopkins University - Baltimore MD
International Classification:
A61K 38/08
US Classification:
514 16, 514 15, 530328, 530329
Abstract:
The invention provides isolated PSMA binding peptides, as well as pharmaceutical compositions thereof. Also provided are diagnostic and therapeutic methods utilizing the PSMA binding peptides, as well as methods for identifying further PSMA binding peptides.
Ronald Rodriguez - Glenwood MD, US Shawn Edward Lupold - Ellicott City MD, US Wasim Haider Chowdhury - Laurel MD, US Tarana A. Kudrolli - Frederick MD, US
Assignee:
The Johns Hopkins University - Baltimore MD
International Classification:
C12N 15/87
US Classification:
435462, 435465, 435466, 435475, 435477, 435488
Abstract:
The instant invention provides methods and compositions for generating recombinant adenoviral vectors. The invention also provides kits comprising for the generation of recombinant adenoviral vectors.
Compositions And Methods For Generating And Screening Adenoviral Libraries
The present invention provides DNA libraries, libraries of viral clones and libraries of infectious viral particles and methods of generating and screening these libraries.
Compositions And Methods For Treatment Of Cancer Using Tissue-Specific Oncolytic Adenoviruses
The present invention includes the use of a nucleic acid sequence encoding an shRNA to target RNA interference against a cellular factor where such use can enhance oncolytic adenovius replication. The nucleic acid sequence encoding an shRNA can be introduced into an oncolytic adenovius construct via a recombination event, and such nucleic acid sequence encoding an shRNA can reside in either the E1 region or Fiber region of the oncolytic adenovius construct. In particular, the oncolytic adenovius construct optionally include a prostate specific promoter or prostate specific enhancer for issue specific expression in prostate cancer cells. The oncolytic adenovius constructs of the invention provides utility for the treatment of cancers, in particular prostate cancer.
Compositions And Methods For Retargeting Virus Constructs
Shawn Edward Lupold - Ellicott City MD, US Ping Wu - Baltimore MD, US Ronald Rodriguez - Glenwood MD, US
Assignee:
THE JOHNS HOPKINS UNIVERSITY - Baltimore MD
International Classification:
C12N 15/86 C12N 15/10
US Classification:
424 932, 4353201, 506 9
Abstract:
The present invention relates to the field of viral gene therapy. More specifically, A the present invention provides compositions and methods for retargeting virus constructs. In one embodiment, the present invention provides an adenoviral construct comprising a nucleic acid encoding the peptide sequence MAE-X-PDP, wherein X is an antigen targeting peptide. In a more specific embodiment, an adenoviral construct comprises a nucleic acid sequence encoding the peptide sequence MAEWQPDTAHHWALTLPDP inserted into the HI-loop of adenovirus fiber protein. In yet another embodiment, the present invention provides a method for optimizing adenoviral infection of target cells comprising the steps of (a) generating a peptide-display adenovirus library, wherein the displayed peptide is a peptide that specifically binds an antigen expressed on the surface of a target cell, and wherein the displayed peptide is flanked by random peptide sequences; and (b) screening the peptide-display adenovirus library against the target cells.
Compositions And Methods For Detecting And Quantifying Circulating Tumor Cells (Ctcs)
Shawn Edward Lupold - Ellicott City MD, US Wasim Haider Chowdhury - Laurel MD, US Ping Wu - Baltimore MD, US Ronald Rodriguez - Glenwood MD, US
Assignee:
THE JOHNS HOPKINS UNIVERSITY - Baltimore MD
International Classification:
C12Q 1/68 C12N 15/86
US Classification:
435 5, 4353021
Abstract:
The present invention relates to the field of virology. More specifically, the present invention relates to the use of viral constructs to detect and quantify circulating tumor cells. In one embodiment, the present invention provides an adenovirus construct comprising (a) a cell type specific promoter that drives adenoviral replication; and (b) at least one reporter gene incorporated into the viral Major Late Transcriptional Unit. In another embodiment, an adenovirus construct comprises (a) prostate selective pro-basin promoter operably linked to the El gene; and (b) prostate specific antigen enhancer operably linked to the probasin promoter.
Name / Title
Company / Classification
Phones & Addresses
Ronald Rodriguez
Ronald Rodriguez MD Urologist
601 N Caroline St, Baltimore, MD 21287 4109554494
Ronald Rodriguez Governing
BROKEN DOWN INVESTMENTS LLC
2611 Middle Ground, San Antonio, TX 78245 1911 Crk Knl, San Antonio, TX 78253
Ronald K. Rodriguez President
TANGLEWOOD SHORES OWNERS ASSOCIATION Civic/Social Association
1381 Greenbriar Dr, Canyon Lake, TX 78133 2205 Potters Crk Rd, New Braunfels, TX 78133 1422 Greenbriar Dr, New Braunfels, TX 78133
Jun 2012 to 2000 QC Manager Melaleuca Mass Rearing AnnexGreat Lakes Dredge & Dock Baltimore, MD Nov 2011 to Feb 2012 QC System ManagerCeres Environmental Service
May 2011 to Nov 2011 QC Manager, Removal Emergencies Levees & Site Restoration on Minot & Ward CountyShoreline Foundations Pembroke, FL 2010 to May 2011 QC Manager Consultant, Philadelphia, PAShoreline Foundations Port Saint Lucie, FL 2010 to 2011 QC MangerLara Group, Ltd El Paso, TX 2010 to 2010 ConsultantLara Group, Ltd El Paso, TX 2008 to 2010 QC ManagerLara Group, Ltd
2007 to 2010Ceres Environmental Services, Inc
Oct 2008 to Nov 2008 QC ManagerCeres Environmental & Services Galveston, TX Sep 2008 to Oct 2008 QC ManagerLara Group, Ltd
2008 to 2008 Consultant- DirectorCeres Environmental Services, Inc Brooklyn Park, MN 2004 to 2008Ceres Environmental & Services
Sep 2005 to Aug 2007 Corporate Quality Control ManagerCeres Environmental & Services
2005 to 2005 Quality Control & Safety ManagerCeres Environmental & Services Dallas, TX 2005 to 2005 QC ManagerCeres Environmental & Services Palm Beach, Florida, US 2004 to 2005 Quality Control ManagerFlorida Development Group Plantation, FL 2001 to 2003Sol Roofing Ponce, PR 1995 to 2000 QC Manager & ConsultingCIFRA International Group Venezuela, PR 1986 to 1995 Project ManagerPetrleos de Venezuela -PDVSA
1982 to 1986 Construction Inspection Manager
Education:
Purdue University 1982 B.S. in Civil Engineering
Medicine Doctors
Dr. Ronald Rodriguez, San Antonio TX - MD (Doctor of Medicine)
8300 Floyd Curl Dr Suite 4Th - 4B, San Antonio, TX 78229 2104509600 (Phone)
Certifications:
Urology, 2001
Awards:
Healthgrades Honor Roll
Languages:
English
Education:
Medical School Baylor College Of Medicine Graduated: 1992 Medical School John Hopkins Hospital Graduated: 1998 Medical School Massachusetts Institute Of Technology (Mit) Graduated: 1984
Googleplus
Ronald Rodriguez
Work:
Durham Catholic District School Board - Chief Information Officer (2001) GryphTech - Chief Technology Officer (2011-2011) Xtreme Technology Solutions - Owner - Senior Consultant | Information Technology (2008-2011) BoardSuite Corp. - Vice President, Information Technology (2010-2010) Market Wire - Chief Technology Officer (1995-2008)
About:
Over 15 years of IT professional experience overseeing large-scale network and applications deployment, from initial feasibility analysis and conceptual design through implementation and enhancements....
Tagline:
Ronald Rodriguez has more than 15 years of IT professional experience overseeing enterprise IT infrastructure and application development
Ronald Rodriguez
Work:
Instituto Superior de Formación Docente Salomé Ureña - Soporte Técnico (2004)
Education:
UASD - Contabilidad
Ronald Rodriguez
Work:
I.D.B. - Socio
Education:
Universidad tecnologica de panama - Ing. civil
Ronald Rodriguez
Work:
Aascoutz LLC - Ceo (2006)
Tagline:
Serving the needs of 1.6 and GO SK
Ronald Rodriguez
Work:
Imagin/ART - Gerente General (2012)
Ronald Rodriguez
Work:
Creaciones los mil modelos - Gerente
Education:
Iutoms - Administracion
Ronald Rodriguez
Education:
Universidad de Oriente - ING.INDUSTRIAL
Ronald Rodriguez
Education:
Harvard University
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RONALD RODRIGUEZ MEDINA
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12 Oct, 2010
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Dignified Transfer of USMC Sgt. Ronald A. Rod...
Footage of the dignified transfer of US Marine Corps Sgt. Ronald A. Ro...
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ronald rodriguez
ronald rodriguez
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REEL RONALD RODRIGUEZ 2011
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KARATE DO UZK I CAMPAMENTO KATA RONALD RODRIG...
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Ronald Rodriguez canta sobreviviendo en "La F...
El Miercoles 19 de Agosto de 2009 Ronald y Jara hicieron una versin Un...