Ronald B Tuttle

US Patent:

47742305, Sep 27, 1988

Filed:

Mar 26, 1988

Appl. No.:

6/844417

Inventors:

Ronald R. Tuttle - Plantation FL
Ross Dixon - Boca Raton FL
Maciej M. Smulkowski - Gainesville FL

Assignee:

Ivax Laboratories, Inc. - Miami FL

International Classification:

A61K 3170
C07H 1524

US Classification:

514 27

Abstract:

Intestine-specific delivery of an opioid antagonist can be accomplished without substantial central nervous system effects by administering the antagonist orally in the form of the glucuronide derivative.

US Patent:

44541422, Jun 12, 1984

Filed:

May 26, 1983

Appl. No.:

6/479639

Inventors:

Ronald R. Tuttle - Miami FL

Assignee:

Key Pharmaceuticals, Inc. - Miami FL

International Classification:

A61K 31485

US Classification:

424260

Abstract:

Provided is a method of orally treating a child having a tendency to be overactive to the extent of requiring an external control which comprises orally administering to said child a pharmaceutically effective amount of 6-methylene-6-desoxy-N-cyclopropylmethyl-14-hydroxydihydronormorphone to said patient, whereby the patient tends to reduce his food intake.

US Patent:

44838603, Nov 20, 1984

Filed:

Sep 12, 1983

Appl. No.:

6/531326

Inventors:

Ronald R. Tuttle - Plantation FL

Assignee:

Key Pharmaceuticals, Inc. - Miami FL

International Classification:

A61K 31485

US Classification:

424260

Abstract:

A method of orally treating a child having a tendency to be overactive to the extent of requiring an external control which comprises orally administering to said child a pharmaceutically effective amount of (-)-17-(cyclopropylmethyl)-4,5-alpha-epoxy-3,14-dihydroxymorpinan-6-one to said patient, whereby the attention span of the child lengthened. An oral sustained release dosage unit containing (-)-17-(cyclopropylmethyl)-4,5-alpha-epoxy-3,14-dihydroxymorpinan-6-one is disclosed also.

US Patent:

45622060, Dec 31, 1985

Filed:

Mar 8, 1984

Appl. No.:

6/587444

Inventors:

Ronald R. Tuttle - Plantation FL

Assignee:

Key Pharmaceuticals, Inc. - Miami FL

International Classification:

C07C10329
C07C 69017
A61K 31165
A61K 31225

US Classification:

514548

Abstract:

A method for increasing cardiac contractility in a warm-blooded animal suffering from acutely depressed cardiac contractility which comprises administering to said animal an effective amount of a compound of the formula ##STR1## wherein R is hydrogen or isobutyrate, or a pharmaceutically acceptable acid addition salt thereof.

US Patent:

44242093, Jan 3, 1984

Filed:

Jun 21, 1982

Appl. No.:

6/390349

Inventors:

Ronald R. Tuttle - Plantation FL

Assignee:

Key Pharmaceuticals, Inc. - Miami FL

International Classification:

A61K 3173
C08B 3716

US Classification:

424180

Abstract:

Cardiac contractility agents are provided which are 3,4-di-isobutyryloxy-N-�3-(4-isobutyryloxyphenyl)-1-methyl-n-propyl!-beta- phenethylamine, preferably orally deliverable forms which are cyclodextrin complexes.

US Patent:

45115702, Apr 16, 1985

Filed:

Mar 28, 1983

Appl. No.:

6/479638

Inventors:

Ronald R. Tuttle - Miami FL

Assignee:

Key Pharmaceuticals, Inc. - Miami FL

International Classification:

A61K 31485

US Classification:

514282

Abstract:

A method is provided for orally treating a patient suffering from senile dementia which comprises the periodic oral delivery of a pharmaceutically effective amount of 6-methylene-6-desoxy-N-cyclopropylmethyl-14-hydroxydihydronormorphone to said patient, whereby the patient tends to reduce his food intake. Also provided is an oral sustained release dosage unit form suitable for treating a patient suffering from obesity which permits a prolonged interval between administration to said patient, said oral dosage unit formulation comprising a plurality of granules which together constitute a pharmaceutically effective amount of 6-methylene-6-desoxy-N-cyclopropylmethyl-14-hydroxydihydronormorphone to provide a sustained action over said prolonged interval, said plurality of granules each comprising a polymeric matrix to permit a substantially even release of said 6-methylene-6-desoxy-N-cyclopropylmethyl-14-hydroxydihydronormorphone to permit the necessary sustained release over the prolonged period of time.

US Patent:

44253362, Jan 10, 1984

Filed:

May 24, 1982

Appl. No.:

6/381567

Inventors:

Ronald R. Tuttle - Plantation FL

Assignee:

Key Pharmaceuticals, Inc. - Miami FL

International Classification:

A61K 3173
C08B 3716

US Classification:

424180

Abstract:

Cardiac contractility agents are provided which are 3,4-dihydroxy-N-[3-(4-hydroxyphenyl)-1-methyl-n-propyl]-beta-phenethylamin e cyclodextrin complexes.