Ronald C White

US Patent:

7504517, Mar 17, 2009

Filed:

Jun 19, 2007

Appl. No.:

11/765359

Inventors:

John Michael Janusz - West Chester OH, US
Stephen Joseph Hodson - Mason OH, US
Gregory Kent Bosch - West Chester OH, US
Ronald Eugene White - West Chester OH, US
Benjamin E. Blass - Eagleville PA, US
Christopher M. Jackson - Gahanna OH, US
Neil T. Fairweather - Liberty Township OH, US

Assignee:

Wyeth - Madison NJ

International Classification:

C07D 233/38
A61K 31/4166

US Classification:

5483221, 514392

Abstract:

The present invention relates to 1-N-amino-2-imidazolidinones and derivatives thereof which are effective as Kv1. 5 potassium channel inhibitors providing atrial-selective antiarrhythmic agents. The present invention further relates to compositions comprising said Kv1. 5 potassium channel inhibitors, and to methods for treating cardiac arrhythmia.

US Patent:

7803827, Sep 28, 2010

Filed:

Nov 6, 2008

Appl. No.:

12/266212

Inventors:

John Michael Janusz - West Chester OH, US
Stephen Joseph Hodson - Mason OH, US
Gregory Kent Bosch - Goshen OH, US
Ronald Eugene White - West Chester OH, US
Benjamin E. Blass - Eagleville PA, US
Christopher M. Jackson - Gahanna OH, US
Neil T. Fairweather - Liberty Township OH, US

Assignee:

Wyeth LLC - Madison NJ

International Classification:

A61K 31/4166
C07D 233/32

US Classification:

514392, 5483221

Abstract:

The present invention relates to 1-N-amino-2-imidazolidinones and derivatives thereof which are effective as Kv1. 5 potassium channel inhibitors providing atrial-selective antiarrhythmic agents. The present invention further relates to compositions comprising said Kv1. 5 potassium channel inhibitors, and to methods for treating cardiac arrhythmia.

US Patent:

54341477, Jul 18, 1995

Filed:

Oct 8, 1993

Appl. No.:

8/133704

Inventors:

Ronald W. White - West Chester OH
Thomas P. Demuth - Norwich NY

Assignee:

Proctor & Gamble Pharmaceuticals, Inc. - Norwich NY

International Classification:

C07D47104
A61K 31435

US Classification:

514210

Abstract:

Antimicrobial quinolonyl lactam esters comprising a lactam-containing moiety linked, by an ester group, to the 3-carboxy group of a quinolone moiety. These compounds are of the formula: ##STR1## wherein (1) R. sup. 3, R. sup. 4, and R. sup. 5, together with bonds "a" and "b", form certain lactam-containing moieties similar to those known in the art to have antimicrobial activity; and (2) A, R. sup. 6, R. sup. 7, and R. sup. 8 form any of a variety of quinolone or napthyridine structures similar to those known in the art to have antimicrobial activity.

US Patent:

56461631, Jul 8, 1997

Filed:

Apr 28, 1994

Appl. No.:

8/235003

Inventors:

Thomas Prosser Demuth - Montgomery OH
Ronald Eugene White - West Chester OH

Assignee:

The Procter & Gamble Company - Cincinnati OH

International Classification:

A61K 3147
C07D215233
C07D21558

US Classification:

514312

Abstract:

The invention relates to antimicrobial 5-(N-heterosubstituted amino) quinolone compounds having a structure according to Formula (I) or (II): ##STR1## wherein (1) R. sup. 1, R. sup. 2, R. sup. 3, R. sup. 9 and R. sup. 10 form any of a variety of quinolone and related heterocyclic structures similar to those known in the art to have antimicrobial activity; and (2) (a) R. sup. 4 and R. sup. 5 are, independently, hydrogen; lower alkyl; cycloalkyl; heteroalkyl; or --C(. dbd. O)--X--R. sup. 8, where X is a covalent bond, N, O, or S, and R. sup. 8 is lower alkyl, lower alkenyl, arylalkyl, a carbocylic ring, or a heterocyclic ring; or (b) R. sup. 4 and R. sup. 5 together comprise a heterocyclic ring that includes the nitrogen to which they are bonded; and the pharmaceutically-acceptable salts, biohydrolyzable esters, biohydrolyzable amides, and solvates thereof. The invention also relates to compositions comprising these compounds, as well as methods for treating infectious disorders using the compounds and/or compositions of the present invention.

US Patent:

41433602, Mar 6, 1979

Filed:

Aug 27, 1976

Appl. No.:

5/720702

Inventors:

James I. Bernhart - Fort Wayne IN
James W. Nobles - Fort Wayne IN
Ronald L. White - Fort Wayne IN

Assignee:

The Magnavox Company - Fort Wayne IN

International Classification:

G06K 1518
G06F 314

US Classification:

340711

Abstract:

A versatile display terminal having the capability of off-line operation or on-line operation in conjunction with a variety of computer systems. The display terminal has a programmable microprocessor and ROM and RAM memories thereby providing the capability of working independently of a central computer. The programmable microprocessor provides a high degree of flexibility for satisfying special requirements with minimal hardware changes. The display terminal preferably has a display panel operable with digital inputs. A vector generator employs a unique method of generating a vector display on the panel. A character generator has the capability of generating standard display terminal characters as well as special characters.