Ronald Wiley

US Patent:

7741435, Jun 22, 2010

Filed:

Mar 30, 2004

Appl. No.:

10/813856

Inventors:

Douglas A. Lappi - Del Mar CA, US
Ronald G. Wiley - Brentwood TN, US

Assignee:

Advanced Targeting Systems, Inc. - San Diego CA

International Classification:

A61K 38/00
A61K 47/48
C07K 14/415
C07K 7/00

US Classification:

530326, 530350, 514 13, 514 12, 514 2

Abstract:

This invention provides a conjugate comprising Substance P, or an analog thereof, and a protein, such as Saporin, that inhibits protein synthesis. This invention provides a method of reducing the perception of pain by a subject comprising administering to the subject an effective amount of the pharmaceutical composition of the conjugate comprising Substance P, or an analog thereof, and a protein such as Saporin that inhibits protein synthesis, so as to reduce the perception of pain by the subject. This invention provides a method of selectively destroying NK-1R-expressing neuronal cells in a subject comprising administering to the subject an effective amount of the conjugate comprising Substance P, or an analog thereof, and a protein such as Saporin that inhibits protein synthesis, so as to selectively destroy NK-1R-expressing neuronal cells. Lastly, this invention provides a method for treating a NK-1R-associated disorder in a subject, which comprises administering to the subject an amount of the pharmaceutical composition comprising substance P, or an analog thereof, and a protein such as Saporin that inhibits protein synthesis, in an effective amount to treat the disorder associated with the NK-1R.

US Patent:

20110028402, Feb 3, 2011

Filed:

Jun 21, 2010

Appl. No.:

12/820128

Inventors:

Douglas A. Lappi - Del Mar CA, US
Ronald G. Wiley - Brentwood TN, US

Assignee:

Advanced Targeting Systems, Inc. - San Diego CA

International Classification:

A61K 38/16
C07K 19/00
C12N 9/96
A61P 25/00
A61P 35/00

US Classification:

514 183, 530402, 435188, 5303911, 514 193

Abstract:

This invention provides a conjugate comprising Substance P, or an analog thereof, and a protein, such as Saporin, that inhibits protein synthesis.This invention provides a method of reducing the perception of pain by a subject comprising administering to the subject an effective amount of the pharmaceutical composition of the conjugate comprising Substance 9, or an analog thereof, and a protein such as Saporin that inhibits protein synthesis, so as to reduce the perception of pain by the subject.This invention provides a method of selectively destroying NK-1R-expressing neuronal cells in a subject comprising administering to the subject an effective amount of the conjugate comprising Substance P, or an analog thereof, and a protein such as Saporin that inhibits protein synthesis, so as to selectively destroy NK-1R-expresssing neuronal cells.Lastly, this invention provides a method for treating a NK-1R-associated disorder in a subject, which comprises administering to the subject an amount of the pharmaceutical composition comprising substance P, or an analog thereof, and a protein such as Saporin that inhibits protein synthesis, in an effective amount to treat the disorder associated with the NK-1R.

US Patent:

50728598, Dec 17, 1991

Filed:

May 18, 1990

Appl. No.:

7/525518

Inventors:

Ronald L. Wiley - Marietta GA
Benjamin D. Miller - Chicago IL
Phillip B. Groover - Woodstock GA

Assignee:

The Coca-Cola Company - Atlanta GA

International Classification:

B67D 108

US Classification:

222148

Abstract:

An automatic beverage dispenser having a multiflavor automatic beverage dispensing valve (faucet) and including means for preventing color and flavor carryover from one drink to the next. The automatic dispenser includes an electronic control system with an on-board computer with a microprocessor which, when a drink vend signal is received by the electronic control system, first checks to determine whether a dark or light colored drink was requested, then checks the last vend to determine if it was a light or dark drink. If the drink ordered was a light drink and the previous drink was a dark drink, then the controller looks to see if the cup dispenser position is occupied. If it is occupied, the flush is delayed until it is free when the soda water will flush to cleanse the nozzle. After flushing, the vend is processed.

US Patent:

51411300, Aug 25, 1992

Filed:

Sep 14, 1990

Appl. No.:

7/583254

Inventors:

Ronald L. Wiley - Marietta GA
Benjamin D. Miller - Chicago IL

Assignee:

The Coca-Cola Company - Atlanta GA

International Classification:

B67B 700

US Classification:

222 1

Abstract:

An automatic beverage dispenser having a single flavor or a multiflavor automatic beverage dispensing valve (faucet) and including a system for preventing the dispensing of a warm casual drink. The automatic dispenser includes an on-board computer having a timer circuit to purge the warm water in the uncooled portion of the water line between the cooling apparatus and the dispensing valve whenever a drink is requested and no drink has been dispensed for a particular period of time. The warm water is purged or drained out for a period of time needed to purge the warm water from the uncooled portion of the water line. In another embodiment, a temperature sensor is included in the water line and the warm water purging terminates when the temperature falls to a predetermined value.

US Patent:

46746560, Jun 23, 1987

Filed:

Oct 22, 1984

Appl. No.:

6/663136

Inventors:

Ronald L. Wiley - Marietta GA
Robert C. Iwans - Simsbury CT

Assignee:

The Coca-Cola Company - Atlanta GA

International Classification:

B67D 556

US Classification:

2221291

Abstract:

A post-mix beverage dispenser apparatus includes a syrup compartment in which a plurality of inverted flavor concentrate containers are plugged into sockets associated with selectively actuatable dispensing nozzles. The containers are also supported by snapping the sidewalls thereof into conformally shaped cooling fins. The fins and containers are properly dimensioned so that a snap-fit results therebetween. The cooling fins are directly attached to a thermally conductive plate which is in direct thermal contact with a water reservoir. Water within the reservoir is chilled by a suitable refrigeration device disposed therein. A carbonator tank is also disposed within the water reservoir. An agitator assembly rests on top of the water reservoir and includes an impeller, a heat sink and a pair of ice detecting probes which extend into the water.

US Patent:

49679325, Nov 6, 1990

Filed:

Feb 27, 1989

Appl. No.:

7/316364

Inventors:

Ronald L. Wiley - Marietta GA
Benjamin D. Miller - Chicago IL

Assignee:

The Coca-Cola Company - Atlanta GA

International Classification:

B67D 562
B67D 508

US Classification:

222 1

Abstract:

An automatic postmix beverage dispenser having a single or multiflavor automatic beverage dispensing valve (faucet) and including means for preventing the dispensing of a warm casual drink. The automatic dispenser includes an on-board computer having a timer circuit to purge the warm water in the uncooled portion of the water line between the cooling means and the automatic beverage dispensing valve whenever a drink is requested and no drink has been dispensed for a particular period of time. The warm water is drained out for a period of time needed to drain the warm water in the uncooled portion of the water line. In another embodiment, a thermometer is used and the water is purged when a drink is requested and the water temperature is above a certain value, and until it is reduced to a desired temperature.

US Patent:

52958078, Mar 22, 1994

Filed:

Mar 1, 1993

Appl. No.:

8/024703

Inventors:

Ronald L. Wiley - Marietta GA
John H. Bearden - Marietta GA

Assignee:

The Coca-Cola Company - Atlanta GA

International Classification:

F04B 4900

US Classification:

417274

Abstract:

An auxiliary chamber is connected to the main pumping chamber of a liquid dispensing pump. The auxiliary chamber includes a resilient rolling diaphragm in fluid communication with the fluid in the main pumping chamber and is expandable for receiving liquid from the main pumping chamber during an output stroke with an adjustable stop member being located behind the diaphragm for restricting the displacement of the diaphragm by the volume of fluid entering the secondary chamber from the pumping chamber and thus controlling the output from the pump by controlling the net internal pump chamber volume.

US Patent:

50586300, Oct 22, 1991

Filed:

May 18, 1990

Appl. No.:

7/525932

Inventors:

Ronald L. Wiley - Marietta GA
Benjamin D. Miller - Chicago IL
Phillip B. Groover - Woodstock GA

Assignee:

The Coca-Cola Company - Atlanta GA

International Classification:

B65B 304
B65B 5700

US Classification:

141 1

Abstract:

An automatic beverage dispensing system including a conveyor, a multiflavor valve, and a programmable cup drop system which includes means for searching through a plurality of separate cup supply tubes for a cup of the selected size.