Rondo P Middleton

US Patent:

20070231371, Oct 4, 2007

Filed:

Jan 31, 2007

Appl. No.:

11/701029

Inventors:

Yuanlong Pan - Chesterfield MO, US
Rondo Middleton - Creve Coeur MO, US
Steven Hannah - Chesterfield MO, US

International Classification:

A61K 36/899
A61K 36/54
A61K 36/87
A61K 33/32
A61K 31/555
A61K 31/12

US Classification:

424442000, 514688000, 424642000, 424766000, 424776000, 424769000, 424739000, 424750000, 424523000, 514184000

Abstract:

Disclosed herein are dietary formulations and methods to mimic the physiological, biochemical and gene expression effects of calorie restriction without altering dietary intake. The formulations include combinations of nutrients that have various intended functions in the body, falling into three or more of the following activities; (1) antioxidant activity; (2) inhibition of glycation damage; (3) reduction of body weight and fat; and (4) promotion of high insulin sensitivity and low blood insulin/glucose; and (5) anti-inflammatory activity.

US Patent:

20070298416, Dec 27, 2007

Filed:

Feb 2, 2005

Appl. No.:

10/587791

Inventors:

Rondo Middleton - Creve Coeur MO, US
Steven Hannah - Chesterfield MO, US

Assignee:

NESTEC S.A. - Vevey

International Classification:

C12Q 1/68
C07H 21/02
C12M 1/34
G01N 33/53
C12N 5/02

US Classification:

435006000, 435287200, 435377000, 435007100, 536023100

Abstract:

Described herein is a combination containing polynucleotide molecules that are differentially expressed in osteoarthritis. Also described are methods that may be used for diagnosis and prognosis of osteoarthritis, as well as methods that may be used to screen test substances for effectiveness in treatment modalities for osteoarthritis. Also described are devices and kits that may be used with the described methods.

US Patent:

20110052753, Mar 3, 2011

Filed:

Feb 5, 2009

Appl. No.:

12/735651

Inventors:

Brian Michael Zanghi - Gowanda NY, US
Arleigh James Reynolds - Salcha AK, US
Rondo Paul Middleton - Creve Coeur MO, US

International Classification:

A23K 1/16
A23K 1/00

US Classification:

426 2, 426656, 426583, 426541

Abstract:

Compositions and methods for influencing the recovery of an animal from the effects of strenuous physical activity. The compositions generally comprise about 4% to 6% readily absorbable carbohydrate; about 10% to 30% maltodextrins; about 20% to 50% starch, for a total of about 40% to 80% carbohydrate; about 20% to about 40% protein; and optionally one or more antioxidants. The methods generally comprise administering the composition to an animal within the period from about 120 minutes before initiation of or 120 minutes after completion of the physical activity.

US Patent:

20110183870, Jul 28, 2011

Filed:

Aug 10, 2009

Appl. No.:

12/737745

Inventors:

Yuanlong Pan - Chesterfield MO, US
Steven Hannah - Chesterfield MO, US
Rondo Middleton - Creve Coeur MO, US

International Classification:

C40B 40/08
C40B 40/10
C40B 40/06

US Classification:

506 17, 506 18, 506 16

Abstract:

Gene expression profiles associated with improved or maintained lean body mass or reduced body fat are disclosed. The gene expression profiles were determined in adipose, liver, and muscle tissue of animals subjected to lean-promoting regimens such as consumption of a high protein diet, ingestion of conjugated linolenic acid, and/or increased exercise. Methods of using such profiles for the identification of pharmaceutical substances, nutraceutical substances, dietary substances, or treatment regimens that modulate or contribute to desired phenotypes in animals are also disclosed

US Patent:

20120040855, Feb 16, 2012

Filed:

Mar 10, 2010

Appl. No.:

13/138523

Inventors:

Yuanlong Pan - Chesterfield MO, US
Steven Scott Hannah - Chesterfield MO, US
Rondo Paul Middleton - Creve Coeur MO, US
Janet Rosann Jackson - Columbia IL, US
Tomas Alberto Prolla - Madison WI, US
Richard Howard Weindruch - Madison WI, US
Jamie Louis Barger - Verona WI, US
Thomas Darwin Pugh - Madison WI, US

International Classification:

C40B 30/04
C40B 40/10
C40B 40/06
C12Q 1/68
C40B 40/08

US Classification:

506 9, 435 61, 506 17, 506 16, 506 18, 435 612

Abstract:

The invention provides methods of developing tissue-specific biomarkers of aging, sets of robust biomarkers identified by those methods, and uses of the biomarkers to identify nutrients and other functional ingredients or agents having anti-aging properties.

US Patent:

20130178450, Jul 11, 2013

Filed:

May 18, 2011

Appl. No.:

13/698136

Inventors:

Rondo Paul Middleton - Creve Coeur MO, US
Nongnuch Inpanbutr - Columbus OH, US

Assignee:

Nestec SA - Vevey

International Classification:

A61K 31/593
A61K 45/06

US Classification:

514167, 435 612, 552653

Abstract:

Methods and compositions for increasing the production or activity of catalase in an animal are disclosed. The methods comprise administering vitamin D to the animal in an amount effective to increase catalase production or activity. Methods for treating catalase deficiency, extending the prime years of an animal's life, promoting health and wellness of an animal, and improving the quality of life for an animal through the vitamin D-mediated increase in catalase production or activity are also disclosed. Methods of screening for vitamin D mimetics based on their ability to increase the production or activity of catalase in cells in a manner similar to vitamin D are also disclosed.

US Patent:

20130209583, Aug 15, 2013

Filed:

Oct 21, 2011

Appl. No.:

13/881507

Inventors:

Yuanlong Pan - Chesterfield MO, US
Steven Scott Hannah - Chesterfield MO, US
Rondo Paul Middleton - Creve Coeur MO, US

Assignee:

Nestec S.A. - Vevey

International Classification:

A61K 33/04
A61K 45/06
A61K 31/015
A61K 31/01
A61K 31/355
A61K 31/341

US Classification:

424702

Abstract:

The invention provides methods, compositions, and dietary formulations useful for preventing or treating dermatitis, promoting healthy skin, and retarding skin aging. The methods comprise administering to an animal a therapeutically effective amount of a combination of at least two of one or more antioxidants; one or more anti-glycation agents; one or more body fat reducing agents; one or more insulin sensitivity enhancing agents; and one or more anti-inflammatory agents.

US Patent:

20130316029, Nov 28, 2013

Filed:

Dec 15, 2011

Appl. No.:

13/996245

Inventors:

Yuanlong Pan - Chesterfield MO, US
Rondo Paul Middleton - Creve Coeur MO, US
Steven Scott Hannah - Chesterfield MO, US

Assignee:

NESTEC S.A. - Vevey

International Classification:

A61K 31/355
A61K 31/198
A61K 31/047
A61K 31/375
A61K 36/87
A61K 31/015

US Classification:

424766, 514458

Abstract:

The invention provides methods, compositions, and dietary formulations useful for managing blood glucose, preventing or treating insulin resistance, and improving insulin sensitivity. The methods comprise administering to an animal a therapeutically effective amount of a combination of at least two of one or more antioxidants; one or more anti-glycation agents; one or more body fat reducing agents; one or more insulin sensitivity enhancing agents; and one or more anti-inflammatory agents.