Rosa D Maldonado

US Patent:

20230009415, Jan 12, 2023

Filed:

Jul 1, 2022

Appl. No.:

17/856241

Inventors:

- Austin TX, US
Igor C. Almeida - El Paso TX, US
Rosa A. Maldonado - El Paso TX, US
Alba A. Montoya - El Paso TX, US
Susana Portillo - El Paso TX, US

International Classification:

G01N 33/569
A61P 33/02
A61K 47/64
A61K 47/42
A61K 47/65

Abstract:

Disclosed are neoglycoconjugates and/or glycosides containing glycan selected from Galpα1,3Galfβ, Galpα1,6Galpα1,3Galfβ, or Galpα1,3Galfβ1,3Manpα. Methods of using the glycosides and/or neoglycoconjugates as diagnostic or prognostic biomarkers, vaccines, treating or detecting parasitic diseases, such as cutaneous leishmaniasis are disclosed.

US Patent:

20180043002, Feb 15, 2018

Filed:

Mar 22, 2016

Appl. No.:

15/555369

Inventors:

Rosa MALDONADO - El Paso TX, US
Igor ALMEIDA - El Paso TX, US
Katja MICHAEL - El Paso TX, US
Eva Adriana INIGUEZ - El Paso TX, US

Assignee:

THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM - Austin TX

International Classification:

A61K 39/008
A61K 39/385

Abstract:

Certain embodiments are directed to an immunogenic composition comprising an immunogenic glycoconjugate comprising a glycan having the chemical formula of galactopyranose (Galp)-α(1,2)-R, Galp-α(1,3)-R, Galp-α(1,4)-R, or Galp-α(1,6)-R, wherein in R is any monosaccharide, oligosaccharide, or polysaccharide, coupled to a carrier peptide or protein. Certain aspects described herein are directed to compounds and therapies for treating infections. In certain aspects, the glycoconjugates as described herein, are incorporated into pharmaceutical compositions or vaccines

US Patent:

20170349606, Dec 7, 2017

Filed:

Jun 14, 2017

Appl. No.:

15/622924

Inventors:

Rachid Skouta - El Paso TX, US
Rosa A. Maldonado - El Paso TX, US

Assignee:

THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM - Austin TX

International Classification:

C07D 495/04
C07F 5/04
C07F 5/02

Abstract:

The present disclosure relates generally to systems, methods, and compounds for therapeutic use against parasitic infections. More particularly, the disclosure relates to anti-parasitic compounds, and methods for making and for using the anti-parasitic compounds, where the anti-parasitic compounds have the general formula:where X, R, R, R, R, R, and Rare defined more fully below.

US Patent:

20170071940, Mar 16, 2017

Filed:

Nov 29, 2016

Appl. No.:

15/363719

Inventors:

Omonike Arike Olaleye - Spring TX, US
Sarah Finney John - Missouri City TX, US
Janice Endsley - Texas City TX, US
Jun O. Liu - Clarksville MD, US
Rosa Maldonado - El Paso TX, US

Assignee:

Texas Southern University - Houston TX
The Board of Regents of the University of Texas System - Austin TX

International Classification:

A61K 31/506
A61K 31/122

Abstract:

The present invention relates to methods for treating an infectious disease in a subject in need thereof via administration of a therapeutically effective amount of compounds described herein. The methods may utilize particular compounds, for example, a quinoline, a hydrazone, a quinone, or a pyrimidine derivative thereof or a pharmaceutical salt thereof.

US Patent:

20170071948, Mar 16, 2017

Filed:

Nov 29, 2016

Appl. No.:

15/363440

Inventors:

Omonike Arike Olaleye - Spring TX, US
Sarah Finney John - Missouri City TX, US
Janice Endsley - Texas City TX, US
Jun O. Liu - Clarksville MD, US
Rosa Maldonado - El Paso TX, US

Assignee:

Texas Southern University - Houston TX
The Board of Regents of the University of Texas System - Austin TX

International Classification:

A61K 31/519
A61K 31/4409

Abstract:

The present invention relates to methods for treating an infectious disease in a subject in need thereof via administration of a therapeutically effective amount of compounds described herein. The methods may utilize particular compounds, for example, a quinoline, a hydrazone, a quinone, or a pyrimidine derivative thereof or a pharmaceutical salt thereof.

US Patent:

20160362420, Dec 15, 2016

Filed:

Jun 10, 2016

Appl. No.:

15/179865

Inventors:

- Austin TX, US
Rosa A. Maldonado - El Paso TX, US

Assignee:

Board of Regents, The University of Texas System - Austin TX

International Classification:

C07D 495/04
C07F 5/04
C07F 5/02

Abstract:

The present disclosure relates generally to systems, methods, and compounds for therapeutic use against parasitic infections. More particularly, the disclosure relates to anti-parasitic compounds, and methods for making and for using the anti-parasitic compounds, where the anti-parasitic compounds have the general formula:where X, R, R, R, R, R, and Rare defined more fully below.

US Patent:

20150290183, Oct 15, 2015

Filed:

Apr 10, 2015

Appl. No.:

14/684300

Inventors:

Rosa A. Maldonado - El Paso TX, US
Miguel A. Vasquez - El Paso TX, US
Jonathan R. Dimmock - Saskatoon, SK
Umashankar Das - Saskatoon, SK

International Classification:

A61K 31/4545
A61K 45/06
A61K 31/13

Abstract:

Embodiments are directed to compositions and methods for treating parasitic infections. Compounds have been identified from a library of anti-cancer drugs that serve as suitable agents for targeting trypanosomatids.

US Patent:

20150141415, May 21, 2015

Filed:

Nov 7, 2014

Appl. No.:

14/536024

Inventors:

Omonike Arike Olaleye - Spring TX, US
Sarah Finney John - Missouri City TX, US
Adaugo Chimzurum Isichei - Sugar Land TX, US
Jun O Liu - Clarksville MD, US
Rosa Maldonado - El Paso TX, US
Janice Endsley - Texas City TX, US

International Classification:

C07D 498/04
C07C 50/24
C07D 401/04
C07D 215/28
C07D 213/86
C07D 495/04

US Classification:

5142298, 514354, 546325, 514267, 544250, 514256, 544328, 514311, 546179, 514682, 568328, 544 95

Abstract:

The present invention relates to methods for treating an infectious disease in a subject in need thereof via administration of a therapeutically effective amount of compounds described herein. The methods may utilize particular compounds, for example, a quinoline, a hydrazone, a quinone, or a pyrimidine derivatives thereof or a pharmaceutical salts thereof.