Ketan Amin - Randolph NJ, US Rose-Marie Dannenfelser - Bloomfield NJ, US Joseph Zielinski - Florham Park NJ, US Barbara Wang - Berkeley Heights NJ, US
International Classification:
A61K 9/14
US Classification:
424486000
Abstract:
Pharmaceutical compositions that include a poorly water-soluble therapeutic compound, an aqueous solvent, a nonvolatile cosolvent and a bulking agent. The pharmaceutical compositions can be orally ingested or administered parenterally. The pharmaceutical compositions can further be lyophilized to form a pharmaceutically acceptable cake that can be administered orally, e.g., as a solid oral dosage form; or reconstituted and administered parenterally, e.g. as a single i.v. bolus.
Rose-Marie Dannenfelser - Bloomfield NJ, US Vivian Georgousis - West Caldwell NJ, US Maha Khaled - Livington NJ, US Tarun Patel - Parsippany NJ, US Joseph Sikora - Succasunna NJ, US Barbara Wang - Berkeley Heights NJ, US
International Classification:
A61K 31/135
US Classification:
514650000
Abstract:
The invention relates to a composition for the treatment of a cyclooxygenase-2-mediated disorder or condition comprising 5-methyl-2-(2′-chloro-6′-fluoroanilino)phenylacetic acid or a pharmaceutically acceptable salt, preferably the potassium salt, thereof suitable for parenteral administration, and to a method for the treatment of a cyclooxygenase-2-mediated disorder or condition in a human or animal in need of such treatment by parenteral administration of 5-methyl-2-(2′-chloro-6′-fluroanilino)phenylacetic acid or a pharmaceutically acceptable salt, preferably the potassium salt, thereof.
Compound Formulations Of 2-Amino-1, 3-Propanediol Compounds
Thitiwan Buranachokpaisan - Morristown NJ, US Rose-Marie Dannenfelser - Bloomfield NJ, US Ping Li - Basking Ridge NJ, US
International Classification:
A61K 31/135 A61P 37/00
US Classification:
514653
Abstract:
Pharmaceutical concentrate formulations comprising 2-amino-1,3-propanediol compounds, analogs thereof and salts thereof, particularly 2-amino-2-[2-(4-octylphenyl)ethyl]-propane-1,3-diol or a pharmaceutically acceptable salt thereof in an organic solvent or semi-aqueous solvent and methods for administration of the undiluted and diluted concentrate are provided.
Rose-Marie Dannenfelser - Bloomfield NJ, US Vivia Christine Georgousis - West caldwell NJ, US Maha Y. Khaled - Livingston NJ, US Tarun S. Patel - Parsippany NJ, US Joseph Sikora - Saccasunna NJ, US Barbara Wang - Berkeley Heights NJ, US
International Classification:
A61K 31/195 A61P 29/00
US Classification:
514567
Abstract:
The invention relates to a composition for the treatment of a cyclooxygenase-2-mediated disorder or condition comprising 5-methyl-2-(2′-chloro-6′-fluoroanilino)phenylacetic acid or a pharmaceutically acceptable salt, preferably the potassium salt, thereof suitable for parenteral administration, and to a method for the treatment of a cyclooxygenase-2-mediated disorder or condition in a human or animal in need of such treatment by parenteral administration of 5-methyl-2-(2′-chloro-6′-fluroanilino)phenylacetic acid or a pharmaceutically acceptable salt, preferably the potassium salt, thereof.
Ketan Amin - Randolph NJ, US Rose-Marie Dannenfelser - Bloomfield NJ, US Joseph Zielinski - Florham Park NJ, US Barbara Wang - Berkeley Heights NJ, US
International Classification:
A61K 9/20
US Classification:
424464000
Abstract:
Pharmaceutical compositions that include a poorly water-soluble therapeutic compound, an aqueous solvent, a nonvolatile cosolvent and a bulking agent. The pharmaceutical compositions can be orally ingested or administered parenterally. The pharmaceutical compositions can further be lyophilized to form a pharmaceutically acceptable cake that can be administered orally, e.g., as a solid oral dosage form; or reconstituted and administered parenterally, e.g. as a single i.v. bolus.
Compound Formulations Of 2-Amino-1, 3-Propanediol Compounds
Thitiwan Buranachokpaisan - Morristown NJ, US Rose-Marie Dannenfelser - Bloomfield NJ, US Ping Li - Basking Ridge NJ, US
International Classification:
A61K 47/10 A61K 31/137
Abstract:
Pharmaceutical concentrate formulations comprising 2-amino-I,3-propanediol compounds, analogs thereof and salts thereof, particularly 2-amino-2-[2-(4-octylphenyl)ethyl]-propane-1,3-diol or a pharmaceutically acceptable salt thereof in an organic solvent or semi-aqueous solvent and methods for administration of the undiluted and diluted concentrate are provided.
Compound Formulations Of 2-Amino-1, 3-Propanediol Compounds
Thitiwan Buranachokpaisan - Morristown NJ, US Rose-Marie Dannenfelser - Bloomfield NJ, US Ping Li - Basking Ridge NJ, US
Assignee:
NOVARTIS AG - Basel
International Classification:
A61K 31/137
US Classification:
514653
Abstract:
Pharmaceutical concentrate formulations comprising 2-amino-1,3-propanediol compounds, analogs thereof and salts thereof, particularly 2-amino-2-[2-(4-octylphenyl)ethyl]-propane-1,3-diol or a pharmaceutically acceptable salt thereof in an organic solvent or semi-aqueous solvent and methods for administration of the undiluted and diluted concentrate are provided.