Roy R Mcdaniel

US Patent:

20190240163, Aug 8, 2019

Filed:

Feb 6, 2019

Appl. No.:

16/269130

Inventors:

- Denver CO, US
Samuel Reinhold, III - Denver CO, US
Clayton J. Nelsen - Aurora CO, US
Dan A. Finkbeiner - Erie CO, US
Roy J. McDaniel - Denver CO, US
Andrew D. Padilla - Westminster CO, US

International Classification:

A61K 9/50

Abstract:

Various embodiments of modified-release multiparticulates (in bead or granule from) are described. The modified-release multiparticulates can comprise a core including a pharmaceutical and/or probiotic agent, optionally with additional excipients or binders to aid in creation of the core, one or more functional coatings disposed on the core and configured to provide a modified-release profile of the pharmaceutical and/or probiotic agent when given orally, and a coating of hypromellose acetate succinate (HPMCAS) disposed on the one or more functional coatings and configured to impart multiparticulate stability in aqueous acidic media. Suspensions including the modified-release multiparticulates are also described.