Roy T Winters

US Patent:

6900316, May 31, 2005

Filed:

Jul 12, 2001

Appl. No.:

10/343803

Inventors:

Howard Isaac Tjiong - Holland MI, US
Roy Thomas Winters - Pinckney MI, US

Assignee:

Warner-Lamber Company - Morris Plains NJ

International Classification:

C07D471/04
C07D239/47

US Classification:

544279, 544317

Abstract:

A process for preparing a 2-(pyridin-4-ylamino)-pyrido[2,3-d]pyrimidine of Formula II comprising reacting a 4-aminopyridine of the formula with an alkali metal amide or hydride and a 2-alkylsulfanyl-pyrido[2,3-d]pyrimidine of Formula I wherein R, R, R′ and R″, and aryl are as defined in the specification.

US Patent:

6982260, Jan 3, 2006

Filed:

Nov 3, 2000

Appl. No.:

10/130843

Inventors:

Mark Robert Barvian - Ann Arbor MI, US
Ellen Myra Dobrusin - Ann Arbor MI, US
James Stanley Kaltenbronn - Ann Arbor MI, US
Peter L. Toogood - Ann Arbor MI, US
Roy Thomas Winters - Pinckney MI, US
Inderjit S. Sidhu - Edmonton, CA
Rajeshwar Singh - Edmonton, CA
Yadagiri Bathini - Alberta, CA
Ronald George Micetich - Sherwood Park, CA

Assignee:

Warner-Lambert Company - Morris Plains NJ

International Classification:

C07D 239/84
C07D 239/78
C07D 239/80
C07D 403/12
A61K 31/517

US Classification:

514218, 5142355, 51426621, 51426622, 5142664, 544119, 544284, 544292, 540575

Abstract:

This invention provides quinazolines that are useful for treating cell proliferative diseases and disorders, such as cardiovascular diseases, infections, cancers, autoimmune diseases, gout, kidney disease, and neurodegenerative diseases and disorders such as Alzheimer's disease. We have now discovered a group of 2-arylamino-7-(alkyl)oxy-8-alkylquinazolines and 8-alkyl-2-arylamino-quinazoline 2,7-diamines that are potent inhibitors of cyclin-dependent kinases (cdks). The compounds are readily synthesized and can be administered by a variety of routes, including orally, and have sufficient bioavailability. This invention also provides pharmaceutical formulations comprising at least one of the quinazoline compounds together with a pharmaceutically acceptable carrier, diluent, or excipient therefor. The invention further provide useful intermediates generated during the production of the quinazoline compounds.

US Patent:

7772243, Aug 10, 2010

Filed:

May 5, 2005

Appl. No.:

11/122345

Inventors:

Stephen Alan Fakhoury - Saline MI, US
Helen Tsenwhei Lee - Ann Arbor MI, US
Jessica Elizabeth Reed - Ann Arbor MI, US
Kevin Matthew Schlosser - Ann Arbor MI, US
Karen Elaine Sexton - Chelsea MI, US
Haile Tecle - Ann Arbor MI, US
Roy Thomas Winters - Pinckney MI, US

Assignee:

Warner-Lambert Company LLC - Morris Plains NJ

International Classification:

A61K 31/517
C07D 239/94
C07D 413/12

US Classification:

51426621, 5142662, 544119, 544284, 544293, 540600

Abstract:

This invention provides quinazoline compounds of the formula:.

US Patent:

8466165, Jun 18, 2013

Filed:

Apr 5, 2010

Appl. No.:

12/754556

Inventors:

Stephen Alan Fakhoury - Saline MI, US
Helen Tsenwhei Lee - Ann Arbor MI, US
Jessica Elizabeth Reed - Ann Arbor MI, US
Kevin Matthew Schlosser - Ann Arbor MI, US
Karen Elaine Sexton - Chelsea MI, US
Haile Tecle - Ann Arbor MI, US
Roy Thomas Winters - Pinckney MI, US

Assignee:

Warner-Lambert Company LLC - Morris Plains NJ

International Classification:

A61K 31/517
A01N 43/90
C07D 239/72

US Classification:

51426621, 544284, 544293

Abstract:

This invention provides quinazoline compounds of the formula:.

US Patent:

8623883, Jan 7, 2014

Filed:

Jun 10, 2013

Appl. No.:

13/914410

Inventors:

Helen Tsenwhei Lee - Ann Arbor MI, US
Jessica Elizabeth Reed - Ann Arbor MI, US
Kevin Matthew Schlosser - North Wales PA, US
Karen Elaine Sexton - Kent, GB
Haile Tecle - Ann Arbor MI, US
Roy Thomas Winters - Pinckney MI, US

Assignee:

Warner-Lambert Company LLC - Morris Plains NJ

International Classification:

A01N 43/54
A61K 31/519
C07D 239/72
C07D 401/00

US Classification:

5142662, 5142661, 544283, 544284

Abstract:

This invention provides quinazoline compounds of the formula:.

US Patent:

20040158065, Aug 12, 2004

Filed:

Feb 4, 2004

Appl. No.:

10/771774

Inventors:

Hubert Barth - Emmendingen, DE
Alexander Bridges - Saline MI, US
Ronald Heemstra - Pinckney MI, US
Nicole Horne - Muskegon MI, US
Robert Hughes - Grand Haven MI, US
Thomas Jacks - Holland MI, US
Dennis McNamara - Ann Arbor MI, US
Simon Schneider - Merzhausen, DE
Klaus Steiner - Emmendingen, DE
Peter Toogood - Ann Arbor MI, US
Roy Winters - Pinckney MI, US

International Classification:

C 07D 4 3/02

US Classification:

544/284000, 544/293000, 544/244000

Abstract:

Methods and materials for preparing irreversible inhibitors of tyrosine kinases of general Formula 1 are disclosed. Such inhibitors, which include N-[4-(3-chloro-4-floro-phenylamino)-7-(3-morpholin-4-yl-propoxy)-quinazolin-6-yl]-acrylamide, are useful for treating cancer, restenosis, atherosclerosis, endometriosis and psoriasis. The disclosed methods employ protecting schemes to minimize undesirable diacryloylamino-quinazoline side products.

US Patent:

20080269293, Oct 30, 2008

Filed:

Aug 22, 2007

Appl. No.:

11/843431

Inventors:

Liguo Chi - Ann Arbor MI, US
Chulho Choi - Mystic CT, US
Andrew G. Geyer - Chicago IL, US
Robert M. Kennedy - Ann Arbor MI, US
Jeffery A. Pfefferkorn - Mystic CT, US
Roy T. Winters - Pinckney MI, US

International Classification:

A61K 31/4152
C07D 231/22
A61K 31/4439
A61P 9/10
A61P 7/02
A61K 31/4453
C07D 401/12

US Classification:

514326, 5483711, 5462761, 546211, 514407, 514341

Abstract:

This invention relates to novel compounds of formula (I)or stereoisomers or pharmaceutically acceptable salts thereof wherein Y, Rthrough R, and Xthrough Xare as defined in the specification, pharmaceutical compositions containing said compounds useful as P2Yantagonists, and to methods of treating thromboembolic disorders.

US Patent:

63132923, Nov 6, 2001

Filed:

Jul 1, 1998

Appl. No.:

9/101105

Inventors:

H. D. H. Showalter - Ann Arbor MI
Roy T. Winters - Ann Arbor MI
Gordon W. Rewcastle - Manurewa, NZ
William A. Denny - Pakuranga, NZ

Assignee:

Warner-Lambert Company - Morris Plains MI

International Classification:

C07D47104

US Classification:

544277

Abstract:

An improved process for the preparation of 4,6-disubstituted pyrido[3,4-d]pyrimidines is described where 5-amino-2-fluoropyridine is converted in seven operations to the desired products, as well as other valuable intermediates used in the process.