Russell L Cole

US Patent:

20120328910, Dec 27, 2012

Filed:

Mar 19, 2012

Appl. No.:

13/423756

Inventors:

Gerardo Jose la O' - Alameda CA, US
Rick Winter - Orinda CA, US
Jonathan L. Hall - San Mateo CA, US
Pallavi Pharkya - Fremont CA, US
Paul Kreiner - Palo Alto CA, US
Russell Cole - San Francisco CA, US

Assignee:

Primus Power Corporation - Hayward CA

International Classification:

H01M 2/40
H01M 10/0563

US Classification:

429 51, 429101, 429 81

Abstract:

A flow battery and method of operating a flow battery. The flow battery includes a first electrode, a second electrode and a reaction zone located between the first electrode and the second electrode. The flow battery is configured with a first electrolyte flow configuration in charge mode and a second flow configuration in discharge mode. The first electrolyte flow configuration is at least partially different from the second electrolyte flow configuration.

US Patent:

20130045399, Feb 21, 2013

Filed:

Aug 16, 2011

Appl. No.:

13/211134

Inventors:

Russell Cole - San Francisco CA, US
Gerardo Jose La O' - Alameda CA, US
Rick Winter - Orinda CA, US

Assignee:

Primus Power Corporation - Hayward CA

International Classification:

H01M 8/18
H01M 2/40

US Classification:

429 51, 429 70

Abstract:

An embodiment relates an electrochemical system. The system includes (a) at least one cell that comprises a first electrode, a second electrode and a reaction zone between the first and second electrode. The system also includes (b) a liquefied halogen reactant (c) at least one metal halide electrolyte and (d) a flow circuit configured to deliver the halogen reactant and the at least one metal-halide electrolyte to the at least one cell. The flow circuit includes an electrolyte reservoir and a halogen reactant/electrolyte separation device comprising a halophilic material.

US Patent:

20220390436, Dec 8, 2022

Filed:

Oct 26, 2020

Appl. No.:

17/771561

Inventors:

- San Francisco CA, US
Russell Cole - San Francisco CA, US
Nathan Schoepp - San Francisco CA, US

International Classification:

G01N 33/50
C12N 15/10
B01L 3/00

Abstract:

The present invention provides compositions, systems, kits, and methods for analyzing the interaction of T-cells and neoantigen presenting cells (and other cells) via discrete entity (e.g., droplet) microfluids. In certain embodiments, a microfluidic device is used to merge a discrete entity containing a T-cell, and a discrete entity containing a neoantigen presenting cell, at a merger region via a trapping element in order to generate a combined discrete entity. In particular embodiments, at least one thousand of such combined discrete entities are formed in about one second. In some embodiments, whether the receptor on the T-cell sufficiently binds the neoantigen to activate the T-Cell is detected (e.g., via detection of cytokine or granzyme B release). In certain embodiments, provided herein are methods for identifying polyfunctional T-cells or NK-cells, as well as methods of screening for such cells that would be cytotoxic if injected into a subject.

US Patent:

20230053160, Feb 16, 2023

Filed:

Dec 16, 2020

Appl. No.:

17/785339

Inventors:

- Oakland CA, US
Pengfei Zhang - San Francisco CA, US
Russell Cole - San Francisco CA, US

International Classification:

C12N 11/08
B01L 3/00
B33Y 10/00
B33Y 30/00
B33Y 50/00

Abstract:

Methods for on-demand printing discrete entities including, e.g., cells, media or reagents to substrates are provided. In certain aspects, the methods include manipulating qualities of the entities or biological components thereof. In some embodiments, the methods may be used to create arrays of microenvironments and/or for two and three-dimensional printing of tissues or structures and/or for in situ printing for microsurgeries. Systems and devices for practicing the subject methods are also provided.

US Patent:

20210096125, Apr 1, 2021

Filed:

Sep 25, 2020

Appl. No.:

17/032922

Inventors:

- San Francisco CA, US
Russell Cole - San Francisco CA, US

International Classification:

G01N 33/50
C12Q 1/6869
B01L 3/00

Abstract:

The present invention provides systems, kits, and methods for analyzing cell-cell interactions, such as transmembrane proteins binding to surface displayed variable regions, via discrete entity (e.g., droplet) microfluidics. In certain embodiments, a plurality of first discrete entities and a plurality of second discrete entities are merged on a substrate to generate a plurality of merged fixed entities (e.g., fixed via an electrical force), each of which contains one cell expressing a transmembrane (TM) protein and labeled clonal cells displaying a heterologous antibody variable region. In certain embodiments, any binding of the clonal cells to the TM expressing cell is detected in each merged fixed entity, and the clonal cells found to bind are treated in order to sequence the nucleic acid encoding the variable region.

US Patent:

20200122135, Apr 23, 2020

Filed:

Aug 27, 2019

Appl. No.:

16/552982

Inventors:

- Oakland CA, US
Adam R. Sciambi - San Francisco CA, US
Russell Cole - San Francisco CA, US
Zev Jordan Gartner - Pacifica CA, US

International Classification:

B01L 3/02
G01N 15/14
B01L 3/00

Abstract:

Methods for delivering discrete entities including, e.g., cells, media or reagents to substrates are provided. In certain aspects, the methods include manipulating and/or analyzing qualities of the entities or biological components thereof. In some embodiments, the methods may be used to create arrays of microenvironments and/or for two and three-dimensional printing of tissues or structures. Systems and devices for practicing the subject methods are also provided.

US Patent:

20180056288, Mar 1, 2018

Filed:

Oct 21, 2015

Appl. No.:

15/520056

Inventors:

- Oakland CA, US
Adam R. Sciambi - San Francisco CA, US
Russell Cole - San Francisco CA, US
Zev Jordan Gartner - Pacifica CA, US

International Classification:

B01L 3/02
B01L 3/00
G01N 15/14

Abstract:

Methods for delivering discrete entities including, e.g., cells, media or reagents to substrates are provided. In certain aspects, the methods include manipulating and/or analyzing qualities of the entities or biological components thereof. In some embodiments, the methods may be used to create arrays of microenvironments and/or for two and three-dimensional printing of tissues or structures. Systems and devices for practicing the subject methods are also provided.

US Patent:

20140255734, Sep 11, 2014

Filed:

Mar 4, 2014

Appl. No.:

14/196699

Inventors:

- Hayward CA, US
Jonathan Hall - San Mateo CA, US
Russell Cole - San Francisco CA, US
Paul Kreiner - San Francisco CA, US

Assignee:

Primus Power Corporation - Hayward CA

International Classification:

H01M 8/02
H01M 8/06
H01M 8/04
H01M 8/18
H01M 8/20

US Classification:

429 51, 429105, 429 81

Abstract:

A flow battery reservoir includes a reservoir housing, an electrolyte inlet configured to provide an electrolyte mixture containing a liquid metal-halide electrolyte solution and a complexed halogen phase at or toward a stagnant zone in a lower portion of the reservoir, and an electrolyte outlet configured to outlet the liquid metal-halide solution from the reservoir. The electrolyte outlet is positioned such that in use the liquid metal-halide solution flows upward against the force of gravity to reach the electrolyte outlet while the complexed halogen phase settles in the stagnant zone.