Samuel James Dominianni - Indianapolis IN Margaret Mary Faul - Zionsville IN Russell Dean Stucky - Indianapolis IN
Assignee:
Eli Lilly and Company - Indianapolis IN
International Classification:
C07C22936
US Classification:
514567, 562444
Abstract:
This invention provides compounds and their pharmaceutically-acceptable salts, pharmaceutical formulations of said compounds, and methods for treating hyperglycemia associated with non-insulin dependent diabetes and for treating hyperlipidemia.
Cycloalkyl, Lactam, Lactone And Related Compounds, Pharmaceutical Compositions Comprising Same, And Methods For Inhibiting -Amyloid Peptide Release And/Or Its Synthesis By Use Of Such Compounds
Jing Wu - San Mateo CA Jay S. Tung - Belmont CA Eugene D. Thorsett - Moss Beach CA Michael A. Pleiss - Sunnyvale CA Jeffrey S. Nissen - Indianapolis IN R. Jeffrey Neitz - San Francisco CA Lee H. Latimer - Oakland CA Varghese John - San Francisco CA Stephen Freedman - Walnut Creek CA Thomas C. Britton - Carmel IN James A. Audia - Indianapolis IN Jon K. Reel - Carmel IN Thomas E. Mabry - Indianapolis IN Bruce A. Dressman - Indianapolis IN Cynthia L. Cwi - Indianapolis IN James J. Droste - Indianapolis IN Steven S. Henry - New Palestine IN Stacey L. McDaniel - Indianapolis IN William Leonard Scott - Indianapolis IN Russell D. Stucky - Indianapolis IN Warren J. Porter - Indianapolis IN
Assignee:
Athena Neurosciences, Inc. - South San Francisco CA Eli Lilly Company - Indianapolis IN
Disclosed are compounds which inhibit -amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimers disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits -amyloid peptide release and/or its synthesis as well as methods for treating Alzheimers disease both prophylactically and therapeutically with such pharmaceutical compositions.
Samuel James Dominianni - Indianapolis IN Margaret Mary Faul - Zionsville IN Russell Dean Stucky - Indianapolis IN
Assignee:
Eli Lilly and Company - Indianapolis IN
International Classification:
C07D26332
US Classification:
514375, 548222
Abstract:
This invention provides compounds and their pharmaceutically-acceptable salts, pharmaceutical formulations of said compounds, and methods for treating hyperglycemia associated with non-insulin dependent diabetes and for treating hyperlipidemia.
Cycloalkyl, Lactam, Lactone And Related Compounds, Pharmaceutical Compositions Comprising Same, And Methods For Inhibiting -Amyloid Peptide Release And/Or Its Synthesis By Use Of Such Compounds
Jing Wu - San Mateo CA Jay S. Tung - Belmont CA Eugene D. Thorsett - Moss Beach CA Michael A. Pleiss - Sunnyvale CA Jeffrey S. Nissen - Indianapolis IN R. Jeffrey Neitz - San Francisco CA Lee H. Latimer - Oakland CA Varghese John - San Francisco CA Stephen Freedman - Walnut Creek CA Thomas C. Britton - Carmel IN James A. Audia - Indianapolis IN Jon K. Reel - Carmel IN Thomas E. Mabry - Indianapolis IN Bruce A. Dressman - Indianapolis IN Cynthia L. Cwi - Indianapolis IN James J. Droste - Indianapolis IN Steven S. Henry - New Palestine IN Stacey L. McDaniel - Bloomington IN William Leonard Scott - Indianapolis IN Russell D. Stucky - Indianapolis IN Warren J. Porter - Indianapolis IN
Assignee:
Athena Neurosciences, Inc. - South San Francisco CA Eli Lilly Company - Indianapolis IN
Disclosed are compounds which inhibit -amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimers disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits -amyloid peptide release and/or its synthesis as well as methods for treating Alzheimers disease both prophylactically and therapeutically with such pharmaceutical compositions.
Cycloalkyl, Lactam, Lactone And Related Compounds, Pharmaceutical Compositions Comprising Same, And Methods For Inhibiting -Amyloid Peptide Release And/Or Its Synthesis By Use Of Such Compounds
Jing Wu - San Mateo CA Jay S. Tung - Belmont CA Eugene D. Thorsett - Moss Beach CA Michael A. Pleiss - Sunnyvale CA Jeffrey S. Nissen - Indianapolis IN R. Jeffrey Neitz - San Francisco CA Lee H. Latimer - Oakland CA Varghese John - San Francisco CA Stephen Freedman - Walnut Creek CA Thomas C. Britton - Carmel IN James A. Audia - Indianapolis IN Jon K. Reel - Carmel IN Thomas E. Mabry - Indianapolis IN Bruce A. Dressman - Indianapolis IN Cynthia L. Cwi - Indianapolis IN James J. Droste - Indianapolis IN Steven S. Henry - New Palestine IN Stacey L. McDaniel - Indianapolis IN William Leonard Scott - Indianapolis IN Russell D. Stucky - Indianapolis IN Warren J. Porter - Indianapolis IN
Assignee:
Athena Neurosciences, Inc. - South San Francisco CA Eli Lilly Company - Indianapolis IN
Disclosed are compounds which inhibit -amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimers disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits -amyloid peptide release and/or its synthesis as well as methods for treating Alzheimers disease both prophylactically and therapeutically with such pharmaceutical compositions.
Cycloalkyl, Lactam, Lactone And Related Compounds, Pharmaceutical Compositions Comprising Same, And Methods For Inhibiting -Amyloid Peptide Release And/Or Its Synthesis By Use Of Such Compounds
Richard C. Thompson - Frankfort IN Stephen Wilkie - Indianapolis IN Douglas R. Stack - Fishers IN Eldon E. VanMeter - Greenwood IN Qing Shi - Carmel IN Thomas C. Britton - Carmel IN James E. Audia - Indianapolis IN Jon K. Reel - Carmel IN Thomas E. Mabry - Indianapolis IN Bruce A. Dressman - Indianapolis IN Cynthia L. Cwi - Indianapolis IN Steven S. Henry - New Palestine IN Stacey L. McDaniel - Martinsville IN Russell D. Stucky - Indianapolis IN Warren J. Porter - Indianapolis IN
Assignee:
Elan Pharmaceutials, Inc. - South San Francisco CA Eli Lilly Company - Indianapolis IN
Disclosed are compounds which inhibit -amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimers disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits -amyloid peptide release and/or its synthesis as well as methods for treating Alzheimers disease both prophylactically and therapeutically with such pharmaceutical compositions.
Cycloalkyl, Lactam, Lactone And Related Compounds, Pharmaceutical Compositions Comprising Same, And Methods For Inhibiting -Amyloid Peptide Release And/Or Its Synthesis By Use Of Such Compounds
Jing Wu - San Mateo CA Jay S. Tung - Belmont CA Eugene D. Thorsett - Moss Beach CA Michael A. Pleiss - Sunnyvale CA Jeffrey S. Nissen - Indianapolis IN Jeffrey Neitz - San Francisco CA Lee H. Latimer - Oakland CA Varghese John - San Francisco CA Stephen Freedman - Walnut Creek CA Thomas C. Britton - Carmel IN James A. Audia - Indianapolis IN Jon K. Reel - Carmel IN Thomas E. Mabry - Indianapolis IN Bruce A. Dressman - Indianapolis IN James J. Droste - Indianapolis IN Steven S. Henry - New Palestine IN Stacey L. McDaniel - Indianapolis IN Russell D. Stucky - Indianapolis IN Warren J. Porter - Indianapolis IN
Assignee:
Athena Neurosciences, Inc. - South San Francisco CA Eli Lilly Company - Indianapolis IN
Disclosed are compounds which inhibit -amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimers disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits -amyloid peptide release and/or its synthesis as well as methods for treating Alzheimers disease both prophylactically and therapeutically with such pharmaceutical compositions.
Cycloalkyl, Lactam, Lactone And Related Compounds, Pharmaceutical Compositions Comprising Same, And Methods For Inhibiting -Amyloid Peptide Release And/Or Its Synthesis By Use Of Such Compounds
Jing Wu - San Mateo CA Jay S. Tung - Belmont CA Eugene D. Thorsett - Moss Beach CA Michael A. Pleiss - Sunnyvale CA Jeffrey S. Nissen - Indianapolis IN R. Jeffrey Neitz - San Francisco CA Lee H. Latimer - Oakland CA Varghese John - San Francisco CA Stephen Freedman - Walnut Creek CA Thomas C. Britton - Carmel IN James A. Audia - Indianapolis IN Jon K. Reel - Carmel IN Thomas E. Mabry - Indianapolis IN Bruce A. Dressman - Indianapolis IN Cynthia L. Cwi - Indianapolis IN James J. Droste - Indianapolis IN Steven S. Henry - New Palestine IN Stacey L. McDaniel - Bloomington IN William Leonard Scott - Indianapolis IN Russell D. Stucky - Indianapolis IN Warren J. Porter - Indianapolis IN
Assignee:
Athena Neurosciences, Inc. - South San Francisco CA Eli Lilly Company - Indianapolis IN
International Classification:
A61K 3155
US Classification:
514220, 514221
Abstract:
Disclosed are compounds which inhibit -amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimers disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits -amyloid peptide release and/or its synthesis as well as methods for treating Alzheimers disease both prophylactically and therapeutically with such pharmaceutical compositions.
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