Ruth M Mayer

US Patent:

55456693, Aug 13, 1996

Filed:

Jun 2, 1994

Appl. No.:

8/252717

Inventors:

Jerry L. Adams - King of Prussia PA
Ralph F. Hall - King of Prussia PA
Dennis Lee - King of Prussia PA
Ruth J. Mayer - King of Prussia PA
George L. Seibel - King of Prussia PA

International Classification:

A61K 31195

US Classification:

514562

Abstract:

This invention relates to the novel compounds and pharmaceutical compositions of Formula (I). This invention also relates to a method of treating or reducing inflammation in a mammal in need thereof, which comprises administering to said mammal an effective amount of a compound or composition of Formula (I).

US Patent:

54708826, Nov 28, 1995

Filed:

Jun 2, 1994

Appl. No.:

8/252716

Inventors:

James S. Dixon - Malvern PA
Raplh F. Hall - Villanova PA
Lisa A. Marshall - Wyndmoor PA
Floyd H. Chilton - Pilot Mountain NC
Ruth J. Mayer - Wayne PA
James D. Winkler - Fort Washington PA

Assignee:

SmithKline Beecham Corp. - Philadelphia PA

International Classification:

A01N 4728

US Classification:

514596

Abstract:

This invention relates to the novel pharmaceutical compositions of Formulas (I) and (II) each of which comprises a compound of Formula (I) or (II) and a pharmaceutically acceptable diluent or carrier. This invention also relates to a method of treating or reducing inflammation in a mammal in need thereof, which comprises administering to said mammal an effective amount of a compound or composition of Formula (I) or (II).

US Patent:

59122706, Jun 15, 1999

Filed:

Nov 22, 1996

Appl. No.:

8/737650

Inventors:

James Scott Dixon - Malvern PA
Ralph Floyd Hall - Villanova PA
Lisa Ann Marshall - Wyndmoor PA
Floyd H. Chilton - Pilot Mountain NC
Ruth Judik Mayer - Wayne PA
James David Winkler - Fort Washington PA

Assignee:

SmithKline Beecham Corporation - Philadelphia PA
The Johns Hopkins University - Baltimore MD

International Classification:

A01N 4728

US Classification:

514576

Abstract:

This invention relates to the novel pharmaceutical compositions of Formulas (I) and (II) each of which comprises a compound of Formula (I) or (II) and a pharmaceutically acceptable diluent or carrier. This invention also relates to a method of treating or reducing inflammation in a mammal in need thereof, which comprises administering to said mammal an effective amount of a compound or composition of Formula (I) or (II).

US Patent:

59225467, Jul 13, 1999

Filed:

Aug 25, 1997

Appl. No.:

8/920234

Inventors:

Ruth Judik Mayer - Wayne PA
Jeffrey Richard Jackson - Collegeville PA
Catherine Elizabeth Ellis - Glassboro NJ

Assignee:

Smithkline Beecham Corporation - Philadelphia PA

International Classification:

C12N 1500
C12N 1585
C12Q 168
C07K 1600

US Classification:

435 6

Abstract:

Human KUZ polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Human KUZ polypeptides and polynucleotides in the design of protocols for the treatment of inflammation, neural degeneration, allergic disorders, or other disorders involving a dis-regulation of the substrate cytokines or receptors, among others, and diagnostic assays for such conditions.

US Patent:

50232509, Jun 11, 1991

Filed:

Aug 24, 1989

Appl. No.:

7/398206

Inventors:

Jerry L. Adams - Wayne PA
Timothy F. Gallagher - Harleysville PA
Ruth J. Mayer - Wayne PA
Brian W. Metcalf - Radnor PA

Assignee:

SmithKline Beecham Corporation - Philadelphia PA

International Classification:

A61K 31575
E07J 900

US Classification:

514179

Abstract:

New 14. alpha. -carboxyalkyl sterols are regulators of HMG-CoA reductase and inhibitors of mammalian 14. alpha. -methyl demethylase and are useful in lowering serum cholesterol levels and treating fungal infections.